Search results for "Zen"
showing 10 items of 3479 documents
Cmentarz Sapieżyński w Stanisławowie
2021
This article presents the history of one of the largest Polish cemeteries in the Eastern Borderlands. Thousands of Poles, including artists, poets, writers, sculptors, prominent politicians, local government officials and soldiers fighting for Polish independence in various uprisings, were buried in the Sapieżyński Cemetery during its 200-year-long history. The necropolis was closed down by the Soviet authorities in 1980, and the entire area was bulldozed. Crushed tombstones were transported outside the city, and a theater building and a hotel were developed on the site. The paper recreates the cemetery’s history and tells the life stories of the most prominent individuals who were laid to …
Synthese substituierter 1,4-Divinylbenzole durch doppelte Heck-Reaktion mit Ethen unter Druck
1999
Substituted 1,4-divinylbenzenes 3a–i were synthesized by twofold Heck coupling from the corresponding 1,4-dibromo) (electron withdrawing substituents) or 1,4-di-iododialkoxybenzenes 1a–i and ethene. Oligomerizations could be suppressed by increasing the pressure of ethene to 30 bar, simultaneously improving the yields of the title compounds.
Low zone tolerance induced by systemic application of allergens inhibits TC1-mediated skin inflammation
2005
Background The induction of tolerance may be a promising target of strategies aimed at preventing harmful allergic diseases. Low zone tolerance (LZT), induced by epicutaneous application of low doses of contact allergens, inhibits the development of T C 1-mediated contact hypersensitivity (CHS). Objective We evaluated the effect of systemic (oral, intravenous) administration of low amounts of haptens on specific immune reactions and tolerance induction. Methods By using the mouse model of LZT, we analyzed immune reactions in vivo (skin inflammation) and T-cell responses in vitro after oral, intravenous, or epicutaneous application of low amounts of the contact allergen 2,4,6-trinitro-1-chlo…
Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity.
2006
Allergic contact dermatitis and contact hypersensitivity (CHS) are characterized by allergen-specific activation of CD8 + and CD4 + T cells and the production of cytokines resulting in an inflammatory response and tissue damage. We show here that the immunosuppressive compound leflunomide ( N -[4-trifluoro-methylphenyl]-5-methylisoxazol-4 carboxamide, HWA 486) (LF) inhibited the contact allergic response induced in mice by epicutaneous application of the haptens dinitrofluorobenzene (DNFB) and oxazolone. The extent of ear swelling remained significantly reduced following repeated challenge with DNFB for up to 18 weeks. LF and DNFB had to be applied simultaneously for inhibition to occur. Th…
Nanodaļiņu nogādāšana uz audzēju šūnām mezenhimālo cilmes šūnu un MDA-MB-231 šūnu 3D kopkultūras modelī
2016
Nanodaļiņas tiek uzskatītas par potenciālām transporta molekulām, kuras varētu nogādāt pretvēža zāles tieši uz audzēju šūnām. Bakalaura darba mērķis bija analizēt vai notiek nanodaļiņu pārnese uz audzēja šūnām mezinhimālo cilmes šūnu un MDA-MB-231 šūnu 3D kopkultūru modelī. Abas šūnu kultūras tika kultivēts S10 barotnē. Šūnu kultūru diferenciēšanai tika izvēlēts CD90 marķieris. MCŠ tika iezīmētas ar QD655 un pēc 6h inkubācijas tika veikta plūsmas citometrijas analīze. 3D kopkultūras modelis tika izveidots izmantojot PolyHEMA pārklājumu. QD pārnese uz vēža šūnām tika analizēta ar plūsmas citometriju pēc 48h kultivēšanas 3D kopkultūras modelī. 97% MCŠ 2D kultūrā pēc 6h inkubācijas uzņem QD655…
Tuning Azoheteroarene Photoswitch Performance through Heteroaryl Design
2017
International audience; Photoswitchable compounds, which can be reversibly switched between two isomers by light, continue to attract significant attention for a wide array of applications. Azoheteroarenes represent a relatively new but understudied type of photoswitch, where one of the aryl rings from the conventional azobenzene class has been replaced with a five-membered heteroaromatic ring. Initial studies have suggested the azoheteroarenes – the arylazopyrazoles in particular – to have excellent photoswitching properties (quantitative switching and long Z isomer half-life). Here we present a systematic computational and experimental study to elucidate the origin of the long thermal hal…
A CNDO/2 study on the additivity and the nature of the non-additivity of the substituent effects on13C NMR shifts in chlorobenzenes and chlorophenols
1980
The general correlation between the electron densities and the 13C NMR chemical shifts is found to be quite poor in the cases discussed. The non-additivities of the substituent effects on the chemical shifts and the CNDO/2 electron densities correlate only weakly. However, when the electron densities are made specific to different types of atomic orbitals, the s electrons have a pronounced effect in all the models tested. This is explained by an indirect effect on the 〈1/r3〉 term of the p electrons. Good correlations are found between the sums of the chemical shifts and the corresponding sums of the substituent charge excesses. The different behaviour of OH and Cl substituents in the additi…
The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis
2015
IBD is a chronic disorder of the gastrointestinal tract characterized by mucosal inflammation and epithelial damage. Biologic therapy has significantly improved the course of the disease but there are still a high percentage of patients that do not respond to current therapies. We aim to determine the effects of the flesh ethanolic extract of Hylocereus polyrhizus (EH) in a mice model of colitis induced by TNBS.Balb/c mice received TNBS (175 mg/kg, 100 μl, i.r.) and six and thirty hours later were administered with EH (1 g/kg, i.p.). Mice were weighted daily and after sacrificing (2 and 4 days after TNBS) we analyzed mucosal histology, myeloperoxidase activity (MPO), the expression of pro-i…
Apologia in defensionem virorum illustr. equestrium, bonorumq. ciuium Valentinorum, In ciuilem Valentini populi seditionem, quam ... Germaniam ... ap…
1543
Capll. orn.
Studien zum Vorgang der Wasserstoffübertragung, 54. Mechanismus und Grenzen der Clemmensen-Reduktion des Acetophenons und verwandter Verbindungen
1978
Bei der Reduktion von Acetophenon nach Clemmensen entstehen auser Ethylbenzol (1; Vier-Elektronen-Ubergang) in von den Reaktionsbedingungen abhangigen Mengen das Hydrodimerisierungsprodukt 2,3-Diphenyl-2,3-butandiol (2; Ein-Elektronen-Ubergang) und dessen Umlagerungsverbindungen 3 und 4, aber weder 1-Phenylethanol noch Styrol (Zwei-Elektronen-Ubergang). Temperatur, Saurekonzentration, Saureart, Reduktionsmittel (amalgamiertes Zink, Zinkamalgam, Cadmium, Zink-Cadmium-Legierung, Cadmiumamalgam, Magnesiumamalgam, Blei, Zink, Blei-Legierung) bestimmen die Anteile der gebildeten Reduktionsprodukte 1 — 4. 1-Phenylethanol und Styrol konnen unter Clemmensen-Bedingungen partiell in Ethylbenzol (1) u…