Search results for "acetamide"

Solvent-modulation of the structure and dimensionality in lanthanoid-anilato coordination polymers.

2018

We show the key role that the size and shape of the solvent molecules may play in the dimensionality and structure of a series of lanthanoid–chloranilato coordination polymers. We report the synthesis, structure and magnetic properties of six different coordination polymers prepared with Er(III) and chloranilato (C6O4Cl22− = 3,6-dichloro-2,5-dihydroxy-1,4-benzoquinone) and six different solvents: [Er2(C6O4Cl2)3(H2O)6]·10H2O (1), [Er2(C6O4Cl2)3(FMA)6]·4FMA·2H2O (2) (FMA = formamide = NH2CHO), [Er2(C6O4Cl2)3(DMSO)4]·2DMSO·2H2O (3) (DMSO = dimethy sulfoxide = Me2SO), [Er2(C6O4Cl2)3(DMF)6] (4) (DMF = dimethylformamide = Me2NCHO), [Er2(C6O4Cl2)3(DMA)4] (5) (DMA = dimethylacetamide = Me2NC(Me)O) …

Coordination behaviour of methazolamide [N(-4-methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene)] acetamide, an inhibitor of carbonic anhydrase enzy…

1993

Abstract The interaction of methazolamide (Hmacm) with Ni(II) ion and ammonia molecules gives rise to the complex of formula [Ni(macm)2(NH3)4]. The complex crystallizes in the monoclinic P21/n space group with a = 14.255(4), b = 7.126(2), c = 12.444(3) A, β = 113.12(3)° and Z = 2. The structure was refined to R = 0.065 (Rw = 0.065). The complex consists of monomeric units which interact through hydrogen bonds and van der Waals contacts. The Ni(II) ion is coordinated with the deprotonated sulfonamido nitrogen of the macm− ligand in axial sites and the ammonia molecules in equatorial positions. IR, electronic spectra and 1H NMR results are also reported.

Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.

2012

Chronic liver disease promotes hepatocellular injury involving apoptosis and triggers compensatory regeneration that leads to the activation of quiescent stellate cells in the liver. The deposition of extracellular matrix from activated myofibroblasts promotes hepatic fibrosis and the progression to cirrhosis with deleterious effects on liver physiology. The role of apoptosis signaling pathways in the development of fibrosis remains undefined. The aim of the current study was to determine the involvement of the caspase-8 homologue cellular FLICE-inhibitory protein (cFLIP) during the initiation and progression of fibrosis. Liver injury and fibrosis from carbon tetrachloride (CCl4) and thioa…

3,5-Diaizvietotu-4-fenil-2-pirolidonu un to strukturālo analogu sintēze

2017

5-Alkil-4-fenil-3-metilēn-2-pirolidonu un to strukturālo analogu sintēze. Baškevičs V., Darba vadītājs: Dr. ķīm. Maksims Vorona. Maģistra darbs. 102 lappuses, 18 attēli, 30 pielikumi, 32 literatūras avoti. Latviešu valodā. Uz Morita-Baylis-Hillman reakcijas produktu bāzes realizēta to acilēšana un nitroalkānu pievienošanas starpproduktam. Iegūtie starpprodukti tika pakļauti reducēšanas reakcijai un iekšmolekulārai ciklizācijai ar eksometilēn grupu saturošo 2-pirolidonu veidošanu. Šim nolūkam bija izmēģinātas vairākas literatūrā eksistējošas 5-alkil-4-fenil-3-metilēn-2-pirolidonu iegūšanas metodes, no kuriem tika izvēlēta reducēšanas reakcija ar dzelzs pulvera palīdzību ledus etiķskābē. Iegū…

The cognition‐enhancing activity of E1R , a novel positive allosteric modulator of sigma‐1 receptors

2013

Background and Purpose Here, we describe the in vitro and in vivo effects of (4R,5S)-2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide (E1R), a novel positive allosteric modulator of sigma-1 receptors. Experimental Approach E1R was tested for sigma receptor binding activity in a [3H](+)-pentazocine assay, in bradykinin (BK)-induced intracellular Ca2+ concentration ([Ca2+]i) assays and in an electrically stimulated rat vas deferens model. E1R's effects on cognitive function were tested using passive avoidance (PA) and Y-maze tests in mice. A selective sigma-1 receptor antagonist (NE-100), was used to study the involvement of the sigma-1 receptor in the effects of E1R. The open-field test…

The Effects of Sulphydryl Reagents on the Binding and Mixed Function Oxidation of Hexobarbital in Rat Hepatic Microsomes

1975

1. The effects of the sulphydryl reagents p-chloromercuribenzoate, N-ethylmaleimide and iodoacetamide on the binding spectrum, oxygen consumption and formation of a suspected substrate-cytochrome P-450-oxygen complex for hexobarbital in rat liver microsomes were investigated. 2. The oxygen consumption caused by hexobarbital oxidation was inhibited non-competitively by all three agents, with 50% inhibition at 4 times 10(-5) M for p-chloromercuribenzoate, 3-7 times 10(-4) M for N-ethylmaleimide and 1-9 times 10(-3) M for iodoacetamide. Cysteamine protected and at least partially reversed this inhibition. 3. p-chloromercuribenzoate inhibited the formation of the cytochrome P-450-substrate-oxyg…

Genotoxic effects of the herbicides alachlor, atrazine, pendimethaline, and simazine in mammalian cells

1994

Liver regeneration induced by a designer human IL‐6/ sIL‐6R fusion protein reverses severe hepatocellular injury

2000

The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-α, and TGF-α). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liv…

Modulation Of Beta2 and Beta3 Integrins in experimental colitis induced by iodoacetamide and enteropathogenic E.Coli

2013

Integrins can modulate the infiltration of inflammatory cells and the secretion of various inflammatory mediators, essential players in the pathogenesis of colitis. This study explores the role of beta2 and beta3 integrin signaling and their possible role in experimental colitis. A total of 160 adult male Sprague-Dawly rats were divided into 4 equal groups: methylcellulose, bacteria, iodoacetamide and iodoacetamide plus bacteria. Clinical symptoms and signs of colitis were checked daily and colonic tissues were biopsied on days 3, 14, 28, and 56 post induction. Histological studies along with histochemical analysis and polymerase chain reaction of beta2, beta3 and alphavbeta3 were performed…

New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens

2013

The synthesis and the in vitro antibacterial activity of novel linezolid-like oxadiazoles are reported. Replacement of the linezolid morpholine C-ring with 1,2,4-oxadiazole results in an antibacterial activity against Staphylococcus aureus both methicillin-susceptible and methicillin-resistant comparable or even superior to that of linezolid. While acetamidomethyl or thioacetoamidomethyl moieties in the C(5) side-chain are required, fluorination of the phenyl B ring exhibits a slight effect on an antibacterial activity but its presence seems to reduce the compounds cytotoxicity. Molecular modeling performed using two different approaches - FLAP and Amber software - shows that in the binding…