Search results for "actinic"
showing 10 items of 25 documents
Safety of Novel Amino-5-laevulinate Photosensitizer Precursors in Photodynamic Therapy for Healthy Human Skin.
2015
Peer reviewed
Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma
2019
ABSTRACTCutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. Although most cSCCs have good prognosis, a subgroup of high-risk cSCC has a higher frequency of recurrence and mortality. Therefore, the identification of molecular risk factors associated with this aggressive subtype is of major interest. In this work we carried out a global-scale approach to investigate the DNA-methylation profile in patients at different stages, from premalignant actinic keratosis to low-risk invasive and high-risk non-metastatic and metastatic cSCC. The results showed massive non-sequential changes in DNA-methylome and identified a minimal methylation signature that discriminates bet…
Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry
2015
Background Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway). Material and Methods Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC). A database was constructed with SPSS version 20, Inc., Chicago, IL, USA, and descriptive statistics were analyzed by X2 test and comparison of means. Resul…
Oral Thrombus: Report of 122 cases with clinically descriptive data
2017
Background The aim of the present study was to assess the frequency and characterize clinic-pathologic aspects of thrombus occurring as a single lesion or in association with other oral pathologies. Material and Methods 122 cases of thrombus from the oral cavity were retrieved. Information regarding site of the lesion, age, sex and clinical diagnosis or hypothesis and associated lesions were collected from the patients´ records. Results The lesions occurred in a wide age range but the 5th decade was the most prevalent and female patients were more affected. The most frequent site for the lesion was the lip, followed by tongue, buccal mucosa, alveolar ridge, gingiva, floor of the mouth and v…
Value of videoroscopy in the detection of alterations of Actinic Cheilitis and the selection of biopsy areas
2015
Background To demonstrate the value of videoroscopy in identifying lesions and alterations not seen by oroscopy and to select the area for biopsy. Material and Methods Eighty patients were subjected to anamnesis, physical exam, videoroscopy exam, toluidine blue test and biopsy. A diagram of the lips was created to record the exact location where the lesion was found. Results Physical exam identified 287 lesions, and videoroscopy identified 587 lesions; erythema and white lesions were the most common lesions associated with actinic cheilitis. Of the 59 performed biopsies, 32 (52.4%) cases were identified by videoroscopy that showed lesions that were not detected during physical examination. …
Oral potentially malignant disorders : clinical-pathological study of 684 cases diagnosed in a Brazilian population
2019
Background The frequency and distribution of oral potentially malignant disorders (OPMD) may vary among different populations. The aim of the present study was to evaluate the clinical-pathological characteristics of OPMD diagnosed in a Brazilian oral pathology laboratory over a period of 11 years. Material and Methods All cases diagnosed as leukoplakia, speckled leukoplakia, erythroplakia, and actinic cheilitis from 2005 to 2015 were analyzed. Clinical information was obtained from laboratory forms and histological information was obtained from histological slides stained with hematoxylin and eosin. Results the final sample was comprised of 684 cases, of which 292 were males and 392 were f…
A retrospective 11-year study on lip lesions attended at an oral diagnostic service
2019
Background The objective of this study was to describe the upper and lower lip lesion occurrence in an oral diagnostic service. Material and Methods Retrospective descriptive sectional study was performed. Clinical records were obtained from the archives of an Oral Diagnostic Service referral center between 2006 and 2016. Data such as gender, age, anatomical location, and diagnosis were collected and categorized. The collected data were submitted to a descriptive analysis and Pearson's chi-square test (p ≤ 0.05). Results A total of 587 patient records of lip lesions were analyzed. Most lesions were diagnosed in female (52.1%) and adults (56.9%) patients in the lower lip (76.2%). Among all l…
Residents'corner February 2014. Editorial: What's new this month?
2014
In this issue of the EJD, two articles shed light on sun-tanning behaviour in southern Europe [1, 2] that will be discussed here. We also critically review an article by Stockfleth et al. [4] who propose the ‘maximum lesion count’ as a new parameter for efficacy assessment of field-directed therapy for actinic keratoses. Last but not least, the publication of Mailhol et al. [5] on food allergies in children with atopic dermatitis will be reviewed.Skin cancer prevention is an important aspect [...]
Ground-based measured and calculated spectra of actinic flux density and downward UV irradiance in cloudless conditions and their sensitivity to aero…
2003
Ground-based spectral measurements of actinic flux density (300–660 nm wavelength) and downward UV irradiance (300–324 nm) under cloudless conditions have been compared with the results of one-dimensional radiative transfer calculations employing concurrent airborne vertical profile measurements of aerosol particle size distributions. Good agreement (within ±10%) between measured and calculated spectra was found. The remaining differences were explained by uncertainties inherent in the aerosol particle microphysical input data and the column ozone content. A respective sensitivity analysis of the calculated spectra, which was based on the observed variability of microphysical properties, ha…
Assembling a consensus on actinic cheilitis: A Delphi study.
2021
Aims: To discuss the terminology to define and classify actinic cheilitis (AC) and to build a consensus on the diagnostic and therapeutic approaches to AC. Methods: Two-round Delphi study using a questionnaire including 34 closed sentences (9 on terminology and taxonomy, 5 on potential for malignant transformation, 12 on diagnostic aspects, 8 on treatment) and 8 open questions. Experts’ agreement was rated using a Likert scale (1–7). Results: A consensus was reached on 24 out 34 statements (73.5%) and on 5 out of 8 (62.5%) close-ended questions. The response rate was identical in both rounds (attrition of 0%). AC is the term with the highest agreement (median of 7 (strongly agree; IQR: 6–7)…