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A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
2016
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN ha…
Changes in levels of triglyceride-rich lipoprotein subfractions during dialysis in uremic patients
2002
From endosomes onwards : membranes, lysosomes and viral capsid interactions
2009
Kirsi Pakkanen haki väitöstutkimuksessaan monitieteellisen lähestymistavan avulla uusia näkökulmia virustutkimukseen. Tutkimus tuo uutta tietoa lipidikalvojen merkityksestä viruksen ja viruksen isäntäsolun elämässä. Tutkimuksessa selvisi, että koiran parvovirus, jota tutkimuksessa käytettiin mallina parvoviruksille ja yleisemmin vaipattomille viruksille, tarvitsee tietynlaisia isäntäsolun lipidikalvojen ominaisuuksia voidakseen vapautua solunsisäisten endosomirakkuloiden sisältä. Erityisen tärkeää tässä vapautumisessa näytti olevan kalvojen juoksevuus sekä jäykkien alueiden hallittu järjestäytyminen kolesterolin avulla. Hyödyntämällä molekyylejä, lääkeaineita, jotka muuttavat kolesteroliavu…
Acid–base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids
2010
Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.
Data from: Parasitic wasp-associated symbiont affects plant-mediated species interactions between herbivores
2018
Microbial mutualistic symbiosis is increasingly recognised as a hidden driving force in the ecology of plant–insect interactions. Although plant‐associated and herbivore‐associated symbionts clearly affect interactions between plants and herbivores, the effects of symbionts associated with higher trophic levels has been largely overlooked. At the third‐trophic level, parasitic wasps are a common group of insects that can inject symbiotic viruses (polydnaviruses) and venom into their herbivorous hosts to support parasitoid offspring development. Here, we show that such third‐trophic level symbionts act in combination with venom to affect plant‐mediated interactions by reducing colonisation o…
Tracking mite trophic interactions by multiplex PCR
2020
Background A thorough knowledge of trophic webs in agroecosystems is essential to achieve successful biological pest control. Phytoseiid mites are the most efficient natural enemies of tetranychid mites, which include several important pests worldwide. Nevertheless, phytoseiids may feed on other food sources including other microarthropods, plants and even other phytoseiids (intraguild predation), which can interfere with biological control services. Molecular gut content analysis is a valuable tool for characterizing trophic interactions, mainly when working on microarthropods such as mites. We have designed new primers for Phytoseiidae, Tetranychidae and Thysanoptera identification and th…
Past and current distribution of Charaxes jasius jasius (Linnaeus, 1767) (Lepidoptera Nymphalidae) in Sicily in relation to its host plant, Arbutus u…
2022
The authors provide an updated overview of the past and present regional distribution of the two-tailed Pasha Charaxes jasius jasius (Linnaeus, 1767) (Lepidoptera Nymphalidae) and its host plant, the strawberry tree Arbutus unedo L. Most of the occurrence data reported in the entomological literature was confirmed, and several new populations have been recently dis- covered. The distribution pattern of the insect and its host plant overlap almost perfectly. C. jasius jasius is more abundant and forms large and stable populations on the Peloritani Mts. and in some areas of the Madonie Mountains. The high number of new records of C. jasius jasius suggests that the species is experiencing a sp…
Multimodal mediational means in assessment of processes : an argument for a hard-CLIL approach
2022
In Japan, CLIL instruction falls under a soft-CLIL approach, content serving as secondary to language instruction. Furthermore, assessment in classrooms in Japan is oftentimes limited to assessing the product summatively. In the paper, we argue for the value of focusing on content in CLIL activities and assessing the process with the goal to promote learning. The present small-scale study at a Japanese university explored how learners (n = 6) used multimodal mediational means to build their conceptual understanding of ‘Earth breathing’ in order to create a presentation on it for a general English course. The further goal was to explore how inferences made from assessing this process of lear…
Positive solutions for nonlinear Robin problems
2017
We consider a parametric Robin problem driven by the p-Laplacian with an indefinite potential and with a superlinear reaction term which does not satisfy the Ambrosetti-Rabinowitz condition. We look for positive solutions. We prove a bifurcation-type theorem describing the nonexistence, existence and multiplicity of positive solutions as the parameter varies. We also show the existence of a minimal positive solution $\tilde{u}_\lambda$ and establish the monotonicity and continuity of the map $\lambda\to \tilde{u}_\lambda$.
Identification of mycorrhiza-regulated genes with arbuscule development-related expression profile
2004
Suppressive subtractive hybridisation was applied to the analysis of late stage arbuscular mycorrhizal development in pea. 96 cDNA clones were amplified and 81, which carried fragments more than 200 nt in size, were sequence analysed. Among 67 unique fragments, 10 showed no homology and 10 were similar to sequences with unknown function. RNA accumulation of the corresponding 67 genes was analysed by hybridisation of macro-arrays. The cDNAs used as probes were derived from roots of wild type and late mutant pea genotypes, inoculated or not with the AM fungus Glomus mosseae. After calibration, a more than 2.5-fold mycorrhiza-induced RNA accumulation was detected in two independent experiments…