Search results for "active protein"

showing 10 items of 328 documents

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

2011

Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels. Methods and Results— We performed a genome-wide association analysis of CRP in 66 185 participants from 15 population-based studies. We sought replication for the genome-wide significant and suggestive loci in a replication panel comprising 16 540 individuals from 10 independent studies. We found 18 genome-wide significant loci, and we provided evidence of replication for 8 of them. Our results confirm 7 previously known loci and introduce 11 novel loci that are implicated in p…

Netherlands Twin Register (NTR)Genome-wide association studyDisease030204 cardiovascular system & hematology0302 clinical medicineDESIGNRisk FactorsFRAMINGHAMNETHERLANDS TWIN REGISTERgeneticsCRP GENE2. Zero hungerGenetics0303 health scienceseducation.field_of_studybiologyCOMMON VARIANTS3. Good healthHNF1AC-Reactive Proteinmyocardial infarctionCardiovascular DiseasesMeta-analysis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingCardiology and Cardiovascular MedicineVasculitisPopulationArticle03 medical and health sciencesINFLAMMATIONSDG 3 - Good Health and Well-beingPhysiology (medical)/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_medicineHumansGenetic Predisposition to DiseaseCORONARY-HEART-DISEASEALPHA-GENEeducation030304 developmental biologyGenetic associationEPIDEMIOLOGIC APPLICATIONSgenome-wide association studyC-reactive proteinmedicine.diseasemeta-analysisinflammationbiology.proteinGENETICALLY ISOLATED POPULATIONMetabolic syndromeBiomarkers
researchProduct

New pathways of increased cardiovascular risk in depression: a pilot study on the association of high-sensitivity C-reactive protein with pro-atheros…

2013

Abstract Background An elevation of inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) can be found in patients with depressive disorders. Inflammatory processes are known to influence atherosclerosis and might also mediate the link between depression and diabetes. The present study aimed at comparing hs-CRP and its relationship with atherogenic platelet markers in patients with type 2 diabetes (TD2) and/or newly diagnosed major depression (MD). Methods Hs-CRP concentrations in 24 patients with TD2, 21 patients with MD (diagnosed according to ICD-10 and DSM-IV), 19 patients with TD2 and comorbid MD, and 25 healthy controls were compared using analysis of variance. The…

OncologyAdultBlood PlateletsMalemedicine.medical_specialtyCD40 LigandMedizinPilot ProjectsType 2 diabetesDiseaseComorbidityRisk FactorsInternal medicineDiabetes mellitusmedicineHumansPlateletDepression (differential diagnoses)Depressive Disorder MajorCD40biologybusiness.industryC-reactive proteinMiddle Agedmedicine.diseaseAtherosclerosisPsychiatry and Mental healthClinical PsychologyEndocrinologyC-Reactive ProteinDiabetes Mellitus Type 2Cardiovascular DiseasesCase-Control Studiesbiology.proteinFemaleAnalysis of variancebusinessBiomarkersJournal of affective disorders
researchProduct

Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study

2013

Objectives: Traditional clinical risk factors are associated with inflammation cross-sectionally, but associations of longitudinal variation in inflammatory biomarkers with corresponding changes in clinical risk factors are incompletely described. We sought to analyze clinical factors associated with change in inflammation in the community.Methods: We studied 3013 Framingham Offspring (n = 2735) and Omni Cohort (n = 278) participants (mean age 59 years, 55% women, 9% ethnic/racial minority) who attended two consecutive examination cycles (mean 6.7 years apart). We selected ten inflammatory biomarkers representing distinctive biological functions: C-reactive protein (CRP), intercellular adhe…

OncologyMaleBLOOD-PRESSUREIsoprostanesFramingham Heart StudyRisk FactorsMyocardial infarctionOXIDATIVE STRESSskin and connective tissue diseasesChemokine CCL2Biological markersbiologyLongitudinal studiesMiddle AgedIntercellular Adhesion Molecule-1Inflammatory biomarkersC-REACTIVE PROTEINP-SelectinADIPOSE-TISSUEMassachusettsCardiovascular DiseasesCARDIOVASCULAR-DISEASEFemalemedicine.symptomCardiology and Cardiovascular MedicineVasculitisVasculitismedicine.medical_specialtyInflammationArticleInternal medicinemedicineHumansReceptors Tumor Necrosis Factor Type IIInterleukin 6AgedInflammationbusiness.industryInterleukin-6PERIPHERAL ARTERIAL-DISEASEC-reactive proteinOsteoprotegerinADHESION MOLECULE-1medicine.diseasePHOSPHOLIPASE A(2)Blood pressurePLASMA-CONCENTRATIONMYOCARDIAL-INFARCTIONImmunology1-Alkyl-2-acetylglycerophosphocholine Esterasebiology.proteinsense organsbusinessBiomarkers
researchProduct

Biomarkers for Prognosis and Treatment Response in COVID-19 Patients

2021

During a severe infection such as coronavirus disease 2019 (COVID-19), the level of almost all analytes can change, presenting a correlation with disease severity and survival; however, a biomarker cannot be translated into clinical practice for treatment guidance until it is proven to have a significant impact. Several studies have documented the association between COVID-19 severity and circulating levels of C-reactive protein (CRP) and interleukin-6, and the accuracy of the CRP level in predicting treatment responses has been evaluated. Moreover, promising findings on prothrombin and D-dimer have been reported. However, the clinical usefulness of these biomarkers in COVID-19 is far from …

OncologyTreatment responsemedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Clinical BiochemistryPredictive valueReview Articlemacromolecular substances030204 cardiovascular system & hematologySeverity of Illness IndexSeverityGeneral Laboratory MedicineFibrin Fibrinogen Degradation Products03 medical and health sciences0302 clinical medicineDisease severityInternal medicineSeverity of illnessHumansMedicine030212 general & internal medicineInterleukin 6biologyInterleukin-6SARS-CoV-2business.industryBiochemistry (medical)C-reactive proteinCOVID-19General MedicinePrognosisCoronavirusClinical PracticeMicroRNAsC-Reactive Proteinbiology.proteinBiomarker (medicine)businessBiomarkersAnnals of Laboratory Medicine
researchProduct

Prognostic Influence of Pre-Operative C-Reactive Protein in Node-Negative Breast Cancer Patients

2014

The importance of inflammation is increasingly noticed in cancer. The aim of this study was to analyze the prognostic influence of pre-operative serum C-reactive protein (CRP) in a cohort of 148 lymph node-negative breast cancer patients. The prognostic significance of CRP level for disease-free survival (DFS), metastasis-free survival (MFS) and overall survival (OS) was evaluated using univariate and multivariate Cox regression, also including information on age at diagnosis, tumor size, tumor grade, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status, proliferation index (Ki67) and molecular subtype, as well as an assessment of the…

PathologyProliferation indexReceptor ErbB-2lcsh:MedicineEstrogen receptorGastroenterologyMetastasisCohort StudiesBasic Cancer ResearchBreast TumorsMedicine and Health SciencesMedicineNeoplasm Metastasislcsh:ScienceImmune ResponseAged 80 and overUnivariate analysisMultidisciplinarybiologyCancer Risk FactorsHazard ratioObstetrics and GynecologyMiddle AgedPrognosisGene Expression Regulation NeoplasticC-Reactive ProteinOncologyReceptors EstrogenFemaleReceptors ProgesteroneResearch ArticleCancer Predisposing Conditions and SyndromesAdultmedicine.medical_specialtyImmunologyBreast NeoplasmsDisease-Free SurvivalBreast cancerInternal medicineBreast CancerHumansImmune EvasionAgedCell ProliferationProportional Hazards ModelsInflammationGenome Humanbusiness.industryProportional hazards modelGene Expression Profilinglcsh:RC-reactive proteinImmunityBiology and Life SciencesCancers and NeoplasmsCancermedicine.diseaseKi-67 Antigenbiology.proteinWomen's Healthlcsh:QClinical ImmunologyLymph NodesbusinessPLoS ONE
researchProduct

C-reactive protein and efficacy of antiplatelet therapy in (intracranial) atherosclerosis

2018

C-reactive protein (CRP) and other inflammatory biomarkers can indicate both the severity and extent of atherosclerosis, reflecting the inflammatory nature of the disease process.1 Atherogenesis begins with an inflammatory response to vascular injury with cells and mediators initiating the healing response and later inducing growth of atherosclerotic plaques. Inflammation then increases plaque instability, promoting rupture, fissuring, or erosion—the pathogenetic milieu of thrombosis in atherothrombotic ischemic strokes.

Pathologymedicine.medical_specialtyInflammationConstriction PathologicDisease030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicinemedicineHumansbiologyC-reactive protein intracranial atherosclerosisbusiness.industryIschemic strokesC-reactive proteinAtherosclerosismedicine.diseaseThrombosisInflammatory biomarkersC-Reactive Proteinbiology.proteinPlatelet aggregation inhibitorNeurology (clinical)Intracranial Atherosclerosismedicine.symptombusinessPlatelet Aggregation Inhibitors030217 neurology & neurosurgeryNeurology
researchProduct

Pancreas and Cystic Fibrosis: The Implications of Increased Survival in Cystic Fibrosis

2007

Background: In acute pancreatitis (AP), pancreatic necrosis (PN) is an important local complication that can be identified by means of contrast-enhanced computed tomography (CECT).

Pathologymedicine.medical_specialtyNecrosisHepatologybiologybusiness.industryEndocrinology Diabetes and MetabolismfungiC-reactive proteinGastroenterologyfood and beveragesmedicine.diseasemedicinebiology.proteinTechnetium Tc 99m ExametazimePancreatitisAcute pancreatitisIn patientmedicine.symptombusinessComplicationTechnetium-99mPancreatology
researchProduct

Relationship between diabetes and periodontal infection

2015

Periodontal disease is a high prevalent disease. In the United States 47.2% of adults ≥ 30 years old have been diagnosed with some type of periodontitis. Longitudinal studies have demonstrated a two-way relationship between diabetes and periodontitis, with more severe periodontal tissue destruction in diabetic patients and poorer glycemic control in diabetic subjects with periodontal disease. Periodontal treatment can be successful in diabetic patients. Short term effects of periodontal treatment are similar in diabetic patients and healthy population but, more recurrence of periodontal disease can be expected in no well controlled diabetic individuals. However, effects of periodontitis and…

Periodontitismedicine.medical_specialtybiologymedicine.drug_classbusiness.industryEndocrinology Diabetes and MetabolismC-reactive proteinAntibioticsDentistryReviewDiseasemedicine.diseasePeriodontal diseaseMetabolic control analysisDiabetes mellitusInternal medicineInternal Medicinemedicinebiology.proteinbusinessGlycemicWorld Journal of Diabetes
researchProduct

In vitro release of lectins by Phallusia mamillata hemocytes.

1991

Abstract α-Lactose specific lectins are released from Phallusia mamillata hemocytes during short-term cultures. The molecular weight of the subunits, the immunological cross-reaction and the sugar specificity suggest that the released lectins are similar to those isolated from the sonicated hemocytes. Because lectin release appears to take place independently of active protein synthesis, the possibility exists that lectins are pre-formed, stored in hemocytes and released when in vitro conditions stimulate the cells.

PhallusiaAmanitinsHemocytesHemocyteImmunologyBiologyTunicateLectinsAnimalsUrochordataCycloheximideCells Culturedchemistry.chemical_classificationLectinActive proteinbiology.organism_classificationIn vitroCulture MediaBiochemistrychemistryReleasebiology.proteinDactinomycinLiberationGlycoproteinSecretory RateLectinDevelopmental BiologyDevelopmental and comparative immunology
researchProduct

Complement and Atherogenesis

1999

Abstract —Complement activation occurs in temporal correlation with the subendothelial deposition of LDL during early atherogenesis, and complement also plays a pathogenetic role in promoting lesion progression. Two lesion components have been identified that may be responsible for complement activation. First, enzymatic degradation of LDL generates a derivative that can spontaneously activate complement, and enzymatically degraded LDL (E-LDL) has been detected in the lesions. Second, C-reactive protein (CRP) colocalizes with complement C5b-9, as evidenced by immunohistological studies of early atherosclerotic lesions, so the possibility exists that this acute phase protein also fulfills a…

PhosphorylcholineNeuraminidaseComplement Membrane Attack ComplexCoronary Artery DiseaseBiologyPhospholipaseLesionPathogenesismedicineHumansElectrophoresis Gel Two-DimensionalTrypsinComplement Activationchemistry.chemical_classificationPhosphorylcholineC-reactive proteinAcute-phase proteinCholesterol LDLComplement C3Coronary VesselsMolecular biologyComplement systemC-Reactive ProteinEnzymeBiochemistrychemistryType C Phospholipasesbiology.proteinCalciummedicine.symptomCardiology and Cardiovascular MedicineProtein BindingArteriosclerosis, Thrombosis, and Vascular Biology
researchProduct