Search results for "active"
showing 10 items of 5361 documents
EVpedia: a community web portal for extracellular vesicles research
2014
Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more tha…
Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier.
2006
Regulation of Na(+)-dependent glutamate transport was studied in isolated luminal and abluminal plasma membranes derived from the bovine blood-brain barrier. Abluminal membranes have Na(+)-dependent glutamate transporters while luminal membranes have facilitative transporters. This organization allows glutamate to be actively removed from brain. gamma-Glutamyl transpeptidase, the first enzyme of the gamma-glutamyl cycle (GGC), is on the luminal membrane. Pyroglutamate (oxoproline), an intracellular product of GGC, stimulated Na(+)-dependent transport of glutamate by 46%, whereas facilitative glutamate uptake in luminal membranes was inhibited. This relationship between GGC and glutamate tra…
Effect of temperature and organic nutrients on the biodegradation of linear alkylbenzene sulfonate (LAS) during the composting of anaerobically diges…
2004
Limits on the application of biosolids (anaerobically processed sludges from wastewater treatment plants) as fertilizers for the amendment of soil are becoming greater because of the accumulation of recalcitrant substances, making necessary the use of techniques that bring the concentration of xenobiotics to lower concentrations than those permitted. In general, the biosolids composting process is sufficient to reduce the usual concentration of linear alkylbenzene sulfonates (LAS) to low levels. In this work, an assessment is made on the effect of temperature in the capacity of enriched bacterial populations to biodegrade LAS, together with the influence that the available nutrients may hav…
Er:Cr:YSGG laser with electrooptic PLZT ceramics Q-switching Fabry-Perot interferometer output mirror
2001
Summary form only given. Q-switching of Er:Cr:YSGG laser with transparent PLZT ceramics electro-optic modulators was reported previously. The extremely large quadratic EO effect in PLZT allows to build small size moderate control voltages. The high induced birefringence in PLZT results from an essential contribution to polarization (and consequently to the birefringence) of processes with longer relaxation times up to seconds, corresponding to the Er:Cr:YSGG laser operating rate. PLZT ceramics have also a high value of the refractive index (n /spl ap/ 2.2-2.3 for /spl lambda/ = 3 /spl mu/m, slightly depending on PLZT composition and temperature) and thus considerable Fresnel reflections R/s…
Dyakonov-like surface waves in semi-infinite metal-dielectric lattices
2012
We demonstrated the existence of Dyakonov-like surface waves propagating at the boundary between a metal-insulator lattice and an isotropic dielectric. A range of propagation angles substantially greater than that for conventional birefringent materials is obtained, and with reasonably small losses.
Laser-induced anisotropy in terbium-gallium garnet
1998
Ga5O12 crystal when illuminated at the terbium ion resonance, becomes optically uniaxial. The optical axis is found to be along the beam-propagation axis. The origin of this symmetry breakdown is a thermal effect. Our observation of a conoscopic pattern is accounted for by a quadratic stress and refractive index distribution model. By spatial integration of the conoscopic pattern, the laser-induced stress birefringence variation as a function of the incident beam power is determined.
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Bisoprolol Fumarate
2014
Abstract Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing bisoprolol as the sole active pharmaceutical ingredient (API) are reviewed. Bisoprolol is classified as a Class I API according to the current Biopharmaceutics Classification System (BCS). In addition to the BCS class, its therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability problems are taken into consideration. Qualitative compositions of IR tablet dosage forms of bisoprolol with a marketing authorization (MA) in ICH (Inter…
Pas de titre en anglais
2010
Within the quick nano-fabrication techniques evolution and the increasing needs in low space and energy opto-electronic functions on-chip integration, studies and control of electromagnetic resonances of sub-micrometric objects are crucial issues. One aim of this work was then to improve our knowledge of the light-matter interaction. To this end, optical near-field experiments and complementary numerical development of models have been performed to study electromagnetic resonances due to light-matter interaction in sub-micrometric resonators. As an introduction, the first part of the manuscript presents the main phenomena involved in near-field optical microscopy and the used SNOM operation…
Experimental demonstration of phase bistability in a broad-area optical oscillator with injected signal
2015
We demonstrate experimentally that a broad-area laserlike optical oscillator (a nondegenerate photorefractive oscillator) with structured injected signal displays two-phase patterns. The technique [de Valc\'arcel and Staliunas, Phys. Rev. Lett. 105, 054101 (2010)] consists in spatially modulating the injection, so that its phase alternates periodically between two opposite values, i.e., differing by $\ensuremath{\pi}$.
Black hole lightning due to particle acceleration at subhorizon scales
2015
Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry, but still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here, we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC telescopes revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20\% of the gravitational radius of its central black hole. We suggest that the emission is associated …