Search results for "activity"

showing 10 items of 7178 documents

New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens

2019

A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range.

0106 biological sciencesStereochemistryPharmaceutical Science01 natural sciencesjasplakinolide Z<sub>5</sub>Drug Discovery<i>Jaspis splendens</i>Ic50 valuesCytotoxic T cellSpectral analysisPharmacology Toxicology and Pharmaceutics (miscellaneous)lcsh:QH301-705.5cytotoxic activitybiology010405 organic chemistryChemistry010604 marine biology & hydrobiologyMouse LymphomaJaspis splendensbiology.organism_classificationIn vitro0104 chemical sciencesSpongelcsh:Biology (General)Two-dimensional nuclear magnetic resonance spectroscopyjasplakinolide Z<sub>6</sub>Marine Drugs
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Is it advantageous for Atlantic salmon to be triploid at lower temperatures?

2020

Marine organisms living at low temperatures tend to have larger genomes and larger cells which suggest that these traits can be beneficial in colder environments. In fish, triploidy (three complete sets of chromosomes) can be induced experimentally following fertilization, which provides a model system to investigate the hypothesis that larger cells and genomes offers a physiological advantage at low temperatures. We tested this hypothesis by measuring metabolic rates and swimming performance of diploid and triploid Atlantic salmon (Salmo salar) post smolts acclimated to 3 or 10.5 °C. At 10.5 °C, triploids had significantly lower maximum metabolic rates which resulted in a lower aerobic sco…

0106 biological sciencesStrenuous ActivityPhysiology030310 physiologySalmo salarZoologyModel system010603 evolutionary biology01 natural sciencesBiochemistry03 medical and health sciencesOxygen ConsumptionHuman fertilizationVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470AnimalsSalmoGenome sizeSwimming0303 health sciencesbiologyfungibiology.organism_classificationAdaptation PhysiologicalTriploidyCold TemperatureEctothermMetabolic ratePloidyGeneral Agricultural and Biological SciencesDevelopmental Biology
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Effects of gellan-based coating application on litchi fruit quality traits

2018

The use of gellan-based coating formulation on litchi (Litchi chinensis Sonn. ‘Wai Chee’) fruit was investigated in order to determine its ability to improve color conservation and to maintain the overall quality. Fruits were treated with gellanbased coating (0.5% w/v) and glycerol (3% w/v) after dipping in ascorbic acid (1.5% w/v) and then stored at 5°C and 90% relative humidity for 15 days. Changes in peel color, soluble solid content, tritatable acidity, weight loss, antioxidant activity and phenolic content, were measured. Formulations containing gellan-based coating exhibited slightly improved water barrier properties and showed their active role in maintaining color characteristics an…

0106 biological sciencesTitratable acid04 agricultural and veterinary sciencesHorticultureengineering.materialAscorbic acid01 natural sciencesGellan gumSettore AGR/03 - Arboricoltura Generale E Coltivazioni Arboreechemistry.chemical_compoundLitchi fruitLitchi chinensis ‘Wai Chee’ color phenolic content ascorbic acid antioxidant activitychemistryCoatingSoluble solidsSettore BIO/10 - Biochimica040103 agronomy & agricultureGlycerolengineering0401 agriculture forestry and fisheriesRelative humidityFood science010606 plant biology & botanyActa Horticulturae
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Effect of acyl-CoA oxidase activity on the accumulation of gamma-decalactone by the yeast Yarrowia lipolytica: a factorial approach.

2007

International audience; beta-Oxidation is a cyclic pathway involved in the degradation of lipids. In yeast, it occurs in peroxisomes and the first step is catalyzed by an acyl-CoA oxidase (Aoxp). The yeast Yarrowia lipolytica possesses several genes (POX) coding for Aoxps. This study is based on the factorial analysis of results obtained with the many POX derivative strains that have been constructed previously. The effect of interactions between Aoxps on the acyl-CoA oxidase (Aox) activity was important even at the second order. We then investigated the effect of Aox activity on growth and lactone production. Aox activity was correlated with acidification of the medium by cells and with ce…

0106 biological sciencesYarrowia lipolyticaMESH: Enzyme ActivationMetabolic Clearance RateMESH: Factor Analysis StatisticalYarrowiaBiologymodèleModels Biological01 natural sciencesApplied Microbiology and BiotechnologyLactones03 medical and health sciencesEnzyme activatorSpecies SpecificityMESH: Computer Simulation010608 biotechnologyCombinatorial Chemistry TechniquesAcyl-CoA oxidaseMESH: Species SpecificityComputer Simulation030304 developmental biologychemistry.chemical_classificationMESH: Metabolic Clearance Rate0303 health sciencesOxidase testmétabolisme des acides grasAcyl-CoA oxidase activityMESH: Acyl-CoA OxidaseMESH: Models BiologicalYarrowia[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologyGeneral MedicinePeroxisomebiology.organism_classificationYeastEnzyme ActivationBiochemistrychemistrylactoneMolecular MedicineMESH: Combinatorial Chemistry TechniquesMESH: YarrowiaAcyl-CoA OxidaseFactor Analysis StatisticalLactoneMESH: Lactones
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Effects of resveratrol on the ultrastructure of Botrytis cinerea conidia and biological significance in plant/pathogen interactions

2012

International audience; Many roles have been ascribed to stilbenes, namely as antimicrobial, deterrent or repellent compounds in plants, protecting them from attacks by fungi, bacteria, nematodes or herbivores, acting both as constitutive and active defense (phytoalexin) compounds. More recently, stilbenes (especially resveratrol and its derivatives) were acclaimed for their wondrous effects and wide range of purported healing and preventive powers as cardioprotective, antitumor, neuroprotective and antioxidant agents. Although there is a huge number of works concerning the role of resveratrol in human health, reports on the antifungal activity of this compound are still scarce. This study …

0106 biological sciences[SDV]Life Sciences [q-bio]Resveratrol01 natural sciencesConidiumchemistry.chemical_compoundBotrytis cinereaDrug DiscoveryStilbenesDISEASE RESISTANCEVitisPathogenBotrytis cinereachemistry.chemical_classificationELECTRON-MICROSCOPY0303 health sciencesbiologyPhytoalexinfood and beveragesBiological activityGeneral MedicineSpores FungalVITIS-VINIFERA LEAVESAntimicrobialABC TRANSPORTER BCATRB3. Good healthHost-Pathogen Interactions[SDE]Environmental SciencesGrapevineBotrytisSTILBENE PHYTOALEXINSMETABOLISMMicrobiology03 medical and health sciencesPhytoalexinsBotany[SDV.BV]Life Sciences [q-bio]/Vegetal BiologyPLANTSPHYTOALEXIN PHASEOLLINMode of action030304 developmental biologyPlant DiseasesPharmacologyBiological activityfungibiology.organism_classificationchemistryResveratrolGRAPEVINE LEAVESCAUSAL AGENT010606 plant biology & botany
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Life-history genotype explains variation in migration activity in Atlantic salmon (Salmo salar)

2021

AbstractOne of the most important life-history continuums is the fast–slow axis, where “fast” individuals mature earlier than “slow” individuals. “Fast” individuals are predicted to be more active than “slow” individuals; high activity is required to maintain a fast life-history strategy. Recent meta-analyses revealed mixed evidence for such integration. Here, we test whether known life-history genotypes differ in activity expression by using Atlantic salmon (Salmo salar) as a model. In salmon, variation in Vgll3, a transcription co-factor, explains ∼40% of variation in maturation timing. We predicted that the allele related to early maturation (vgll3*E) would be associated with increased a…

0106 biological sciencesbiology010604 marine biology & hydrobiologyZoologybiology.organism_classificationExplained variation010603 evolutionary biology01 natural sciencesVariation (linguistics)Early maturationGenotypeHigh activity14. Life underwaterAlleleSalmoLife history
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Patterns of movement of released female brown bears in the Cantabrian Mountains, northwestern Spain

2017

Between 2008 and 2013, 3 female brown bears (Ursus arctos; 2 cubs-of-the-year and 1 2-yr-old) were rescued, rehabilitated in captivity, radiotagged, and released back to the Cantabrian Mountains, northwestern Spain. We characterized their daily and seasonal movements post-release to gain insights into their movement strategies and the viability of bears released in human-dominated environments. The bears exhibited marked diurnal activity and were active throughout winter. Two bears demonstrated behaviors similar to those reported for wild bears, whereas one cub-of-the-year was recaptured after 21 days because she developed signs of habituation to humans.

0106 biological sciencesbiologyMovementfungiZoologyCaptivityBear releaseManagement Monitoring Policy and LawDaily Activitiesbiology.organism_classification010603 evolutionary biology01 natural sciencesRhythms of activityUrsus arctos010601 ecologyBrown bearAnimal Science and ZoologyHabituationUrsusNature and Landscape ConservationUrsus
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Antimicrobial secondary metabolites from the medicinal plant Crinum glaucum A. Chev. (Amaryllidaceae)

2020

Abstract Medicinal plants are known as sources of potential antibacterial compounds including alkaloids. The aim of the present study was to evaluate the antibacterial activities of the extract, fractions, and some secondary metabolites isolated from the leaves of Crinum glaucum A. Chev. (Amaryllidaceae). The antibacterial activities were performed with the ethanol (EtOH) extract, as well as with ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions. Repeated column chromatography of the fractions led to the isolation of several compounds and their structures were elucidated mainly by means of extensive spectroscopic analysis [(one-dimensional (1D) and two-dimensional (2D) nuclear magnetic…

0106 biological scienceschemistry.chemical_classificationbiologyTraditional medicineUngereminePlant Sciencebiology.organism_classificationLycorineAntimicrobial01 natural sciencesEnterococcus faecalis0104 chemical sciences010404 medicinal & biomolecular chemistrychemistry.chemical_compoundchemistryTriterpeneAntibacterial activityMedicinal plantsOleanolic acid010606 plant biology & botanySouth African Journal of Botany
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Resilience of the seagrass Posidonia oceanica following pulse-type disturbance.

2020

Understanding the response of species to disturbance and the ability to recover is crucial for preventing their potential collapse and ecosystem phase shifts. Explosive submarine activity, occurring in shallow volcanic vents, can be considered as a natural pulse disturbance, due to its suddenness and high intensity, potentially affecting nearby species and ecosystems. Here, we present the response of Posidonia oceanica, a long-lived seagrass, to an exceptional submarine volcanic explosion, which occurred in the Aeolian Archipelago (Italy, Mediterranean Sea) in 2002, and evaluate its resilience in terms of time required to recover after such a pulse event. The study was carried out in 2011 i…

0106 biological sciencesecosystem function and serviceperturbationlepidochronologyAquatic Scienceplant development and life-history Seagrass resilience to pulse-type disturbance traitOceanography010603 evolutionary biology01 natural sciencesrecoveryMediterranean seaFull recoveryhydrothermal activitystable isotopeMediterranean SeaEcosystemaquatic plant ecologyEcosystemRetrospective StudiesCO2 ventgeographygeography.geographical_feature_categoryAlismatalesδ13Cbiology010604 marine biology & hydrobiologySubmarineGeneral Medicinebiology.organism_classificationPollutionSeagrassOceanographyVolcanoItalyPosidonia oceanicaEnvironmental scienceMarine environmental research
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Effects of Acifluorfen-methyl on cucumber cotyledons : porphyrin accumulation

1988

Abstract The nitrodiphenyl ether herbicide acifluorfen-methyl and the pyridine derivative LS 82-556 induce porphyrin accumulation in green cucumber cotyledons. When experiments are done with intact plants absorbing the herbicide through the roots, that accumulation is light-dependent. 3-(3,4-Dichlorophenyl)-1,1-dimethylurea (DCMU) which prevents cellular damages under these conditions (M. Matringe and R. Scalla, Pestic. Biochem. Physiol. 26 , 150 (1986), also inhibits porphyrin accumulation. In contrast, when detached cotyledons are cut into pieces and floated on herbicide solutions, porphyrins accumulate in the dark. Accordingly, DCMU does not inhibit porphyrin accumulation or protect the …

0106 biological sciencesfood.ingredientHealth Toxicology and Mutagenesis[SDV]Life Sciences [q-bio]Acifluorfen01 natural sciences03 medical and health scienceschemistry.chemical_compoundfoodBiosynthesispolycyclic compoundsPHOSPHYRINEComputingMilieux_MISCELLANEOUS030304 developmental biology0303 health sciencesfood and beveragesDCMUBiological activityGeneral MedicineMetabolismPorphyrin[SDV] Life Sciences [q-bio]ChloroplastchemistryBiochemistryAgronomy and Crop ScienceCotyledon010606 plant biology & botany
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