Search results for "actors"
showing 10 items of 11323 documents
Cardiorespiratory Fitness and the Risk of Serious Ventricular Arrhythmias: A Prospective Cohort Study.
2019
Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular disease outcomes. However, the relationship of CRF with risk of ventricular arrhythmias (VAs) is unknown. We aimed to assess the prospective association of CRF with the risk of serious VAs. Cardiorespiratory fitness, as measured by maximal oxygen uptake, was assessed using a respiratory gas exchange analyzer in 2299 middle-aged men in the Kuopio Ischemic Heart Disease prospective cohort. We corrected for within-person variability in CRF levels using data from repeated measurements 11 years apart. During median follow-up of 25.3 years (interquartile range, 18.7-27.2 years), 73 serious VAs were recorded. The age-…
Long-term safety of nine systemic medications for psoriasis: A cohort study using the Spanish Registry of Adverse Events for Biological Therapy in De…
2020
Background: Registry studies broadly describing the safety of systemic drugs in psoriasis are needed. Objective: To describe the safety findings of the systemic drugs acitretin, adalimumab, apremilast, cyclosporine, etanercept, infliximab, methotrexate, secukinumab, and ustekinumab used for the treatment of moderate to severe psoriasis in patients included in the Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases (BIOBADADERM) Registry. Methods: The incidence rate ratio (IRR) and adjusted IRR (including propensity scores) of identified adverse events for each drug, using methotrexate as reference, were determined by means of a prospective cohort. Results: O…
A sustainable city environment through child safety and mobility:A challenge based on ITS?
2012
Our cities should be designed to accommodate everybody, including children. We will not move toward a more sustainable society unless we accept that children are people with transportation needs, and ‘bussing’ them around, or providing parental limousine services at all times, will not lead to sustainability. Rather, we will need to make our cities walkable for children, at least those above a certain age. Safety has two main aspects, traffic safety and personal safety (risk of assault). Besides being safe, children will also need an urban environment with reasonable mobility, where they themselves can reach destinations with reasonable effort; else they will still need to be driven. This p…
Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging
2011
Objective To determine whether pulsed Doppler examination of the ductus venosus in rat fetuses could damage exposed tissue. Methods On gestational day 18, the livers of a mean of approximately five fetuses per mother (n = 5.14, SD = 1.6), in a cohort of 35 pregnant female rats, were exposed individually to pulsed Doppler and these were considered the 'exposed group'. The remaining fetuses in each pregnant rat (n = 5.16, SD = 2.1) formed the 'control group'. We tested for 600, 300, 60, 20, 15, 10 and 3 s of exposure of the fetal ductus venosus and the damage was evaluated measuring a cell death index of apoptotic activity at 7 h post-exposure (n = 16). In addition, subgroups of mothers were …
Saturación arterial de oxígeno durante la ascensión a una montaña de más de 8.000 metros
2008
Fundamento. La saturación arterial de oxígeno (SaO2) disminuye con la altitud. Objetivo. Conocer qué SaO2 presentan los montañeros sanos durante la ascensión a una montaña de más de 8.000 metros. Método. En una expedición al Gasherbrum II (8.035 m) se midió la SaO2 por pulsioximetría durante la marcha de aproximación, en el campamento base (a la llegada y un mes después), en los campamentos II y III, a 7.500 m durante el ataque y en la cumbre. Resultados. En la marcha de aproximación la SaO2 en Paiyu (3.365 m) fue del 92,9 ± 1,4% y en Gore II (4.250 m) del 85,0 ± 4,3%. En el campamento base (5.200 m) a la llegada fue del 78,4 ± 9,5% y un mes después del 87,4 ± 3,0% (p < 0,007). En el campam…
Bridging the gap between research into biological and psychosocial models of psychosis.
2015
Paul Bebbington's recent Special Article provides an excellent synthesis of recent advances in psychosocial research on psychosis. However, we doubt that a model based solely on social epidemiology and cognitive theory can totally describe psychosis, and to be fair, Bebbington does not suggest that it does. A complete model must also incorporate what we have learned from non-social epidemiology, neuroscience, and genetics. Evidence indicates that both the social risk factors that interest Bebbington and biological risk factors, such as abuse of stimulants and cannabis, can provoke psychotic symptoms by dysregulating striatal dopamine. The role of neurodevelopmental deviance also needs to be…
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants show…
Uzmanības deficīta un hiperaktivitātes sindroma ietekme uz skolas uzvedību un sociālajām prasmēm skolas vecuma bērniem
2019
Mūsdienu klasēs, daudzi pedagogi saskaras ar „ārpus kontroles bērniem”. Bērniem, kuriem ir uzmanības deficīts vai hiperaktivitātes sindroms (turpmāk tekstā UDHS), ir neiroloģiski traucējumi, kas ietekmē viņu spēju kontrolēt savu uzvedību un pievērst uzmanību uzdevumiem. Bērni ar UDHS rada īpašu iedzīvotāju grupu ar dažādām vajadzībām izglītības vidē. Izpētītajā pētījumā, tika pievērsta uzmanība uzmanības deficīta un hiperaktivitātes traucējumiem. Pētījuma mērķis bija izpētīt un analizēt dažādas pieejas UDHS, kas saistītas ar problēmām ar vidusskolēniem. Literatūras pārskatā aplūkotās tēmas, ietver dažādas teorijas un kopīgas intervences, ņemot vērā UDHS. Šajā darbā, tika izmantota kvalitatī…
The Joint Distribution Criterion and the Distance Tests for Selective Probabilistic Causality
2010
A general definition and a criterion (a necessary and sufficient condition) are formulated for an arbitrary set of external factors to selectively influence a corresponding set of random entities (generalized random variables, with values in arbitrary observation spaces), jointly distributed at every treatment (a set of factor values containing precisely one value of each factor). The random entities are selectively influenced by the corresponding factors if and only if the following condition, called the joint distribution criterion, is satisfied : there is a jointly distributed set of random entities, one entity for every value of every factor, such that every subset of this set that corr…
Infrastructural and Human Factors Affecting Safety Outcomes of Cyclists
2018
The increasing number of registered road crashes involving cyclists during the last decade, and the high proportion of road crashes resulting in severe injuries and fatalities among cyclists constitutes a global issue for community health, urban development, and sustainability. Nowadays, the incidence of many risk factors for road crashes of cyclists remains largely unexplained. Given the importance of this issue, the present study has been conducted with the aim of determining relationships between infrastructural, human factors and safety outcomes of cyclists. Objectives: This study aimed, first, to examine the relationship between key infrastructural and human factors present in cycling,…