Search results for "actors"

Consensus nomenclature for CD8(+) T cell phenotypes in cancer

2015

International audience; Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T…

Development and validation of the Adolescent Sexting Scale (A-SextS) with a Spanish sample

2020

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Spectrum-shape method and the next-to-leading-order terms of the β-decay shape factor

2017

Effective values of the axial-vector coupling constant gA have lately attracted much attention due to the prominent role of gA in determining the half-lives of double β decays, in particular their neutrinoless mode. The half-life method, i.e., comparing the calculated half-lives to the corresponding experimental ones, is the most widely used method to access the effective values of gA. The present paper investigates the possibilities offered by a complementary method: the spectrum-shape method (SSM). In the SSM, comparison of the shapes of the calculated and measured β electron spectra of forbidden nonunique β decays yields information on the magnitude of gA. In parallel, we investigate the…

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

2013

Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…

MVU ekonomiskās izaugsmes noteicēji Vācijā un Latvijā, fokuss uz ražošanas MVU

2021

Šis darbs ir veltīts mazo un vidējo uzņēmumu (MVU) un to izaugsmes faktoru analīzei. Tajā izklāstīti dažādi faktori, kas ietekmē MVU attīstību, kā arī izaicinājumi un perspektīvas, ar ko tie sastopas mūsdienu globalizētajā un digitalizētajā ekonomikā. Darbā plaši iztirzāta MVU būtiskā loma ekonomikas un sociālās dimensijas iekļaujošā izaugsmē. Šajā darbā arī iekļautas dažādas stratēģijas un valsts programmas, kam ir labvēlīgs iespaids uz uzņēmumu produktivitāti un attīstību. Padziļinātas izpratnes radīšanai kā piemērs ir izvēlēts mazo un vidējo uzņēmumu sektors Latvijā un Vācijā, identificējot abu sektoru trūkumus un priekšrocības.

Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea…

2021

Excessive daytime sleepiness (EDS) is a symptom of obstructive sleep apnea (OSA) that resolves under treatment with continuous positive airway pressure (CPAP). In some patients, sleepiness persists despite CPAP treatment. We retrospectively analyzed data on subjective residual EDS, assessed as an Epworth Sleepiness Scale score (ESS) >10, in patients from the European Sleep Apnea Database (n = 4,853, mean age +/- SD 54.8 +/- 11.8 years, 26.1% females), at baseline and at the first visit (median follow-up: 5 months, interquartile range 3-13). An ESS > 10 occurred in 56% of patients at baseline and in 28.2% of patients at follow-up. Residual EDS was analyzed in 2,190 patients (age: 55.1 +/- 12…

Implementation of IT applications in small and middle size enterprises : controlling the critical success factors

2002

Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL.

2022

Atherosclerosis is responsible for large cardiovascular mortality in many countries globally. It has been shown over the last decades that the reduction of atherosclerotic progression is a critical factor for preventing future cardiovascular events. Low-density lipoproteins (LDL) have been successfully targeted, and their reduction is one of the key preventing measures in patients with atherosclerotic disease. LDL particles are pivotal for the formation and progression of atherosclerotic plaques; yet, they are quite heterogeneous, and smaller, denser LDL species are the most atherogenic. These particles have greater arterial entry and retention, higher susceptibility to oxidation, as well a…

Bezpieczeństwo państwa — czynniki miękkie

2019

This article is divided into three parts, in the fi rst part it is explained what social capital is, and its role in national security is depicted. In the second part, the problem of the importance of social rules in the construction of social capital is discussed. The third part of the article is the culmination of the analysis and shows the role of soft factors in the process of building national security. The quality of social capital depends on how the society works. It is strongly related to other pillars of state security, including the armed forces. The most important message from the content of this article is the statement: a strong society means a safe state.

Social aspects of the power of the state on the example of the visegrad group countries

2018

The article presents the social dimension of the power of the state. A comparative analysis of the dynamics of social progress of the Visegrad Group countries and a statistical analysis of social power-building factors have been carried out. The results presented in the article are the next stage of the author’s work on developing an analytical sub-model of the power of the state in the social area