Search results for "adrenal"
showing 10 items of 416 documents
Effects of inhaled corticosteroids, leukotriene receptor antagonists, or both, plus long-acting beta2-agonists on asthma pathophysiology: a review of…
2004
Chronic inflammation and smooth muscle dysfunction are consistent features of asthma, and are responsible for disease progression and airway remodelling. The development of chronic airway inflammation depends upon the recruitment and activation of inflammatory cells and the subsequent release of inflammatory mediators, including cytokines. Cellular and histological evaluation of drugs with anti-inflammatory activity, such as inhaled corticosteroids (ICSs), is achieved by analysing samples of lung tissue or biological fluids, obtained by techniques such as bronchial biopsy, bronchoalveolar lavage and sputum induction. These provide valuable information on the inflammatory processes occurring…
Use of asthma medication during pregnancy and risk of specific congenital anomalies: A European case-malformed control study.
2015
Background: Pregnant women with asthma need to take medication during pregnancy.Objective: We sought to identify whether there is an increased risk of specific congenital anomalies after exposure to antiasthma medication in the first trimester of pregnancy.Methods: We performed a population-based case-malformed control study testing signals identified in a literature review. Odds ratios (ORs) of exposure to the main groups of asthma medication were calculated for each of the 10 signal anomalies compared with registrations with nonchromosomal, nonsignal anomalies as control registrations. In addition, exploratory analyses were done for each nonsignal anomaly. The data set included 76,249 reg…
Zur Frage des Vorkommens von Isopropylnoradrenalin in Herz und Nebenniere
1959
1. Extracts of adrenal glands and heart tissue of the cat were prepared and chromatographed on paper. The regions corresponding to the RF values of noradrenaline, adrenaline and isoprenaline (isopropylnoradrenaline) were eluted. The eluates were assayed on the blood pressure, the isolated auricle and the isolated uterus of the rat. Differential assay on these preparations proved to be specific and extremely sensitive for isoprenaline. 2. There was no evidence for the occurrence of isoprenaline in the adrenal medulla or the heart of the cat. The method used is sufficiently sensitive to detect 0,2% of isoprenaline in the total catechol amines of the heart and 0,007% in the adrenals.
Die Wirkung von Ouabain auf die Elimination von Noradrenalin aus der Perfusionsfl�ssigkeit des isolierten Kaninchenherzens
1966
Isolated rabbit hearts were perfused with Tyrode solution containing 10 ng/ml (-)-noradrenaline for 20 min. The uptake by the heart of noradrenaline was calculated by estimating the percentage of amine removed from the perfusion fluid during a single passage through the heart. Previous experiments have shown that the amount of noradrenaline removed from the perfusion fluid corresponds well to the amount retained by the heart. In control experiments, the mean removal (elimination) of noradrenaline was 50±1.7% of the amount infused as measured biologically and 46±2.2% as measured fluorimetrically. Ouabain was added to the perfusion fluid at concentrations ranging from 2.74·10−7 to 2.0·10−6 mo…
The intermediate role of 18-hydroxycorticosteroids in aldosterone biosynthesis.
1968
Durch ihre Eigenschaft, bestimmte Stufen bei der Bildung radioaktiv markierten Aldosterons aus14C-Progesteron bzw.3H-11-Desoxycorticosteron zu hemmen, erwiesen sich 11-Desoxycorticosteron, Corticosteron und 18-Hydroxycorticosteron als wesentliche Zwischenstufen der Aldosteronbiosynthese. 18-Hydroxy-11-desoxycorticosteron hingegen scheint an der Bildung von Aldosteron nicht beteiligt zu sein.
Studies on the formation of ?-methylnoradrenaline in hypertensive patients treated with ?-methyldopa
1968
Die renale Elektrolytausscheidung normaler und adrenalektomierter Ratten nach intraven�sen Salzinjektionen und ihre Beeinflussung durch Corticosteroi…
1959
Groups of normal rats of both sexes in moderate water diuresis received i.v. injections of 5 ml./kg, of hypertonic (5 times isoosmotic) solutions of sodium chloride, mannitol er sodium sulfate. The renal excretion of water, sodium, chloride and potassium in a 30 minute-period following this injection was measured. It was compared to control values obtained 40 minutes earlier in the same animals after an i.v. injection of isotonic glucose solution. All hypertonic solutions increased diuresis, natriuresis, chloruresis and kaliuresis. While the effects of mannitol and sodium chloride were comparable, sodium sulfate was more natriuretic and less chloruretic. The excretion of potassium after inj…
Aufnahme und renale Ausscheidung von Wasser und Salzen bei freiem Nahrungs- und Trinkfl�ssigkeitsangebot; ihre Beeinflussung durch Adrenalektomie und…
1959
Water, sodium, potassium and chloride balances, food uptake and changes in body weight were determined in large groups of adrenalectomized or sham-operated rats having permanent access to water, 0.9 per cent saline and rat crackers. Measurements were done on the 5th to 8th day, or else on the 11th to 14th day after operation. From the 3rd day after operation the animals either received s.c. injections of 2.0 ml./kg. 0.9 per cent NaCl per day (controls) or of one of the following hormones: Corticotropin (25 U/kg. b.w./day), Cortisone acetate (12.5mg./kg./day), Cortexone acetate (7.5mg./kg./day) or D,L-Aldosterone acetate (0.15 mg./kg./day). Besides electrolyte balances, plasma concentrations…
Zum Einfluss von Angiotensin II auf die Nebennierenrinde unter chemischer adrenostase mit SU 4885 (Metopiron)
1964
The inhibition of 11-β-hydroxylase in the adrenal cortex with SU 4885 (metopiron) increases the ACTH-secretion. Val5-angiotensin II blocks the reaction of the anterior pituitary gland similarly as does dexamethasone. Mode and intensity of this action of angiotensin II, and the influence on rats treated as described, are studied.