Search results for "aktiivi"
showing 10 items of 1162 documents
The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes
2018
A series of 4-ethynylaniline gold(I) complexes containing monophosphane (1,3,5-triaza-7-phosphaadamantane (pta; 2), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (3), and PR3 , with R=naphthyl (4), phenyl (5), and ethyl (6)) and diphosphane (bis(diphenylphosphino)acetylene (dppa; 7), trans-1,2-bis(diphenylphosphino)ethene (dppet; 8), 1,2-bis(diphenylphosphino)ethane (dppe; 9), and 1,3-bis(diphenylphosphino)propane (dppp; 10)) ligands have been synthesized and their efficiency against tumor cells evaluated. The cytotoxicity of complexes 2-10 was evaluated in human colorectal (HCT116) and ovarian (A2780) carcinoma as well as in normal human fibroblasts. All the complexes showed a hi…
Assessing the Performance of Interactive Multiobjective Optimization Methods
2021
Interactive methods are useful decision-making tools for multiobjective optimization problems, because they allow a decision-maker to provide her/his preference information iteratively in a comfortable way at the same time as (s)he learns about all different aspects of the problem. A wide variety of interactive methods is nowadays available, and they differ from each other in both technical aspects and type of preference information employed. Therefore, assessing the performance of interactive methods can help users to choose the most appropriate one for a given problem. This is a challenging task, which has been tackled from different perspectives in the published literature. We present a …
An Approach to the Automatic Comparison of Reference Point-Based Interactive Methods for Multiobjective Optimization
2021
Solving multiobjective optimization problems means finding the best balance among multiple conflicting objectives. This needs preference information from a decision maker who is a domain expert. In interactive methods, the decision maker takes part in an iterative process to learn about the interdependencies and can adjust the preferences. We address the need to compare different interactive multiobjective optimization methods, which is essential when selecting the most suited method for solving a particular problem. We concentrate on a class of interactive methods where a decision maker expresses preference information as reference points, i.e., desirable objective function values. Compari…
Integration of lot sizing and safety strategy placement using interactive multiobjective optimization
2022
We address challenges of unpredicted demand and propose a multiobjective optimization model to integrate a lot sizing problem with safety strategy placement and optimize conflicting objectives simultaneously. The novel model is devoted to a single-item multi-period problem in periodic review policy. As a safety strategy, we use the traditional safety stock concept and a novel concept of safety order time, which uses a time period to determine the additional stock to handle demand uncertainty. The proposed model has four objective functions: purchasing and ordering cost, holding cost, cycle service level and inventory turnover. We bridge the gap between theory and a real industrial problem a…
Interactivized : Visual Interaction for Better Decisions with Interactive Multiobjective Optimization
2022
In today’s data-driven world, decision makers are facing many conflicting objectives. Since there is usually no solution that optimizes all objectives simultaneously, the aim is to identify a solution with acceptable trade-offs. Interactive multiobjective optimization methods are iterative processes in which a human decision maker repeatedly provides one’s preferences to request computing new solutions and compares them. With these methods, the decision maker can learn about the problem and its limitations. However, advanced optimization software usually offer simple visualization tools that can be significantly improved. On the other hand, current approaches for multiobjective optimization…
Schoolyard affordances for physical activity: a pilot study in 6 Nordic–Baltic countries
2021
Environmental settings influence children’s and adolescents’ physical activity (PA) in neighborhoods and schoolyards. This study aimed to explore the main characteristics of schoolyards in six Nordic–Baltic countries, to document how those facilities provide affordances for PA in 7–18 year–old schoolchildren, and how the schoolyard meets children’s preferences. One schoolyard was studied in each included country: Iceland, Norway, Finland, Lithuania, Latvia, and Estonia. The affordances, facilities, and equipment for PA in schoolyards were identified through orthophoto maps and standard registration forms. Children’s preferences were collected through group interviews at each participating s…
Aktiivisen kansalaisuuden mahdollisuudet kotouttamistyön ulkoisten ehtojen ja maahanmuuttajien tarpeiden ristipaineissa
2018
Nykyisessä poliittisessa keskustelussa aktiivinen kansalaisuus ymmärretään usein kapeasti työkansalaisuutena. Artikkelissa analysoidaan, miten aktiivinen kansalaisuus rakentuu kotouttamistyön rakenteellisten ehtojen ja maahanmuuttajien tarpeiden huomioimisen ristiriidassa. Teoreettisesti nojaudutaan Amartya Senin toimintamahdollisuuksien teoriaan, joka painottaa erilaisten kyvykkyyksien sekä autonomisten toimintamahdollisuuksien merkitystä aktiivisessa kansalaisuudessa. Tuloksena havaitaan, että ammattilaisten näkemyksissä painottuu ristiriita järjestelmän tarpeille rakentuvan työkansalaisuuden ja kotoutujien autonomiaa tukevien toimintamahdollisuuksia vahvistavan työn välille. Myös kotiäi…
Ownership and Use of Commercial Physical Activity Trackers Among Finnish Adolescents: Cross-Sectional Study
2017
BackgroundMobile phone apps for monitoring and promoting physical activity (PA) are extremely popular among adults. Devices, such as heart rate monitors or sports watches (HRMs/SWs) that work with these apps are at sufficiently low costs to be available through the commercial markets. Studies have reported an increase in PA levels among adults with devices; however, it is unknown whether the phenomena are similar during early adolescence. At a time when adolescents start to develop their own sense of independence and build friendship, the ease of smartphone availability in developed countries needs to be investigated in important health promoting behaviors such as PA. ObjectiveThe objective…
Copenhagen consensus statement 2019: physical activity and ageing
2019
From 19th to 22nd November 2018, 26 researchers representing nine countries and a variety of academic disciplines met in Snekkersten, Denmark, to reach evidence-based consensus about physical activity and older adults. It was recognised that the term ‘older adults’ represents a highly heterogeneous population. It encompasses those that remain highly active and healthy throughout the life-course with a high intrinsic capacity to the very old and frail with low intrinsic capacity. The consensus is drawn from a wide range of research methodologies within epidemiology, medicine, physiology, neuroscience, psychology and sociology, recognising the strength and limitations of each of the methods. …
Towards a physically more active lifestyle based on one's own values: study design of a randomized controlled trial for physically inactive adults
2013
Background This randomised controlled trial demonstrates the effectiveness of a value-based intervention program to encourage a physically more active lifestyle among physically inactive adults aged 30 to 50 years. The conceptual framework of the program is based on an innovative behavioural therapy called Acceptance and Commitment Therapy (ACT) that aims to increase an individual’s psychological flexibility and support behaviour change towards a higher quality and more meaningful life. Methods Participants will be randomly allocated to a feedback group (FB) or an Acceptance and Commitment based (ACT + FB) group. Both the groups will receive written feedback about their objectively measured…