Search results for "alfa"

Competencias argumentativas en la alfabetización académica

2011

Este trabajo se enmarca en las numerosas investigaciones sobre escritura académica que vienen desarrollándose en diversos países. Dentro de ellas, buscamos articular líneas de investigación que se ocupan de la alfabetización académica, de los géneros académicos y del papel de la argumentación en los mismos. Para ello, implementamos desde 2005 un programa de alfabetización académica en una asignatura de Humanidades de una universidad argentina, cuyo tramo final es la elaboración y exposición de ponencias grupales, entendidas como construcciones argumentativas que ponen en consideración resultados de investigación. En relación con éstas, este trabajo presenta resultados, en torno a la relació…

Survival and gene expression under different temperature and humidity regimes in ants

2017

Short term variation in environmental conditions requires individuals to adapt via changes in behavior and/or physiology. In particular variation in temperature and humidity are common, and the physiological adaptation to changes in temperature and humidity often involves alterations in gene expression, in particular that of heat-shock proteins. However, not only traits involved in the resistance to environmental stresses, but also other traits, such as immune defenses, may be influenced indirectly by changes in temperature and humidity. Here we investigated the response of the ant F. exsecta to two temperature regimes (20 degrees C & 25 degrees C), and two humidity regimes (50% & 75%), for…

Climate Change: Negationism, Skepticism, and Misinformation

2021

Resumen: El objetivo de este artículo es examinar los principales lineamientos antagonistas sobre el cambio climático. Para ello, se ofrece una aproximación teórica a las narrativas y repertorios sustantivos que sostienen los fundamentos de la negación y se diferencia conceptualmente entre negacionistas, climatoescépticos y contrarios climáticos. Estos repertorios son la negación de las evidencias científicas, la negación económica y la negación política. Finalmente, se hace referencia a la difusión de información errónea y tóxica como estrategia organizada y deliberada. Como principal conclusión se abordan los emergentes programas de alfabetización climática para neutralizar la desinformac…

Evaluation of treatment response to enzyme replacement therapy with Velaglucerase alfa in patients with Gaucher disease using whole-body magnetic res…

2015

Abstract Objective This was a retrospective data analysis to evaluate the treatment response to enzyme replacement therapy (ERT) with Velaglucerase alfa using whole-body magnetic resonance imaging (MRI). Materials and methods A baseline and follow-up MRI were performed on 18 Gaucher Type 1 patients at an interval of 11.6 months. The MRI score systems determined the Bone-Marrow-Burden (BMB) score, the Dusseldorf-Gaucher score (DGS), and the Vertebra-Disc-Ratio (VDR). The Severity Score Index Type 1 (GD-DS3) was also assessed. Results The baseline MRI medians were: BMB, 7.00; DGS, 3.00; and VDR: 1.70; while, the follow-up MRI medians were: BMB, 7.00; DGS, 3.00; and VDR: 1.73. The baseline GD-…

Impact of elosulfase alfa in patients with morquio A syndrome who have limited ambulation: An open-label, phase 2 study.

2017

Efficacy and safety of elosulfase alfa enzyme replacement therapy (ERT) were assessed in an open-label, phase 2, multi-national study in Morquio A patients aged ≥5 years unable to walk ≥30 meters in the 6-min walk test. Patients received elosulfase alfa 2.0 mg/kg/week intravenously for 48 weeks. Efficacy measures were functional dexterity, pinch/grip strength, mobility in a modified timed 25-foot walk, pain, quality of life, respiratory function, and urine keratan sulfate (KS). Safety/tolerability was also assessed. Fifteen patients received elosulfase alfa, three patients discontinued ERT due to adverse events (two were grade 3 drug-related adverse events, the other was not drug-related), …

Lysosomal acid lipase deficiency: Expanding differential diagnosis.

2016

The differential diagnoses for metabolic liver diseases may be challenging in clinical settings, which represents a critical issue for disorders such as lysosomal acid lipase deficiency (LAL-D). LAL-D is caused by deficient activity of the LAL enzyme, resulting in the accumulation of cholesteryl esters and triglycerides throughout the body, predominately in the liver, spleen, gastrointestinal tract, and blood vessel walls. LAL-D is a progressive, multi-organ disease with early mortality and significant morbidity characterized by a combination of hepatic dysfunction and dyslipidemia. Evidence suggests LAL-D may be substantially underdiagnosed or misdiagnosed, which is critical given that dis…

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

2017

Alzheimer’s disease (AD) is characterized by extracellular plaques in the brain, mainly consisting of amyloid-β (Aβ), as derived from sequential cleavage of the amyloid precursor protein. Epidemiological studies suggest a tight link between hypovitaminosis of the secosteroid vitamin D and AD. Besides decreased vitamin D level in AD patients, an effect of vitamin D on Aβ-homeostasis is discussed. However, the exact underlying mechanisms remain to be elucidated and nothing is known about the potential effect of vitamin D analogues. Here we systematically investigate the effect of vitamin D and therapeutically used analogues (maxacalcitol, calcipotriol, alfacalcidol, paricalcitol, doxercalcife…

Sub-analysis of long-term elosulfase alfa treatment outcomes in adults with Morquio syndrome type A

2017

Add-On Peginterferon Alfa-2a Significantly Reduces HBsAg Levels in HBeAg-Negative, Genotype D Chronic Hepatitis B Patients Fully Suppressed on Nucleo…

2016

23 (36%) cases, respectively. Ribavirin (RBV) was used in 35% and 65% of the patients receiving SOF and DCV, respectively. Most of the patients were male (72%) and genotype 1b (81%). Median age was 59 years. Median baseline MELD and Child–Pugh (CPT) scores were 9 and 6, respectively. Among the patients with cirrhosis, 47% were CPT B/C. Tacrolimus was the immunosuppressant used in the majority of the patients (69%). At the beginning of therapy, 20 patients had ascites and 3 had hepatic encephalopathy (HE). Thirty-four patients completed the treatment course and 30 are still on therapy. End of treatment (EOT) response was 88% (30/34) and SVR12 was 83% (25/30). In patients receiving SMV+DCV±RB…

Escritura colaborativa en línea. Un estudio de la revisión textual compartida en la formación inicial de maestros

2020

espanolPresentamos, en el marco de los proyectos de innovacion de la Universidad de Valencia, el analisis de una experiencia de escritura colaborativa en linea. Desde una perspectiva que reune las tesis de escritura y evaluacion como herramientas para aprender, se aplica una metodologia de investigacion-accion para el seguimiento de un proceso de aprendizaje colaborativo: escritura individual, con revision y evaluacion compartidas, a traves de un diario virtual que recoge las sesiones presenciales de la asignatura Lengua Espanola para Maestros, de primer curso de las titulaciones de Magisterio. La muestra analizada, perteneciente a dos cursos academicos, corresponde a la actividad de 84 est…