Search results for "alignment"
showing 10 items of 627 documents
Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q. Sequence similarity of complement subcomponent …
1992
A mouse macrophage lambda gt11 cDNA library was screened using a genomic DNA clone coding for the C-chain gene of human C1q. Approximately 600,000 recombinant phage plaques were hybridized with peroxidase-labeled human C-chain probe and detected by enhanced chemiluminescence. Five positive clones were obtained. The size of the full-length cDNA is 1019 bp. The sequence identity of the nucleotide sequence with human C1q C chain is 79%, the identity of the deduced amino acid sequences is 73%. The mouse C1q C chain exhibits the same structural features as the human C chain, e.g. conservation of the cysteine residues. Like the mouse A chain, the mouse C chain has an RGD sequence that may be reco…
Current bioinformatics tools in genomic biomedical research (Review).
2006
On the advent of a completely assembled human genome, modern biology and molecular medicine stepped into an era of increasingly rich sequence database information and high-throughput genomic analysis. However, as sequence entries in the major genomic databases currently rise exponentially, the gap between available, deposited sequence data and analysis by means of conventional molecular biology is rapidly widening, making new approaches of high-throughput genomic analysis necessary. At present, the only effective way to keep abreast of the dramatic increase in sequence and related information is to apply biocomputational approaches. Thus, over recent years, the field of bioinformatics has r…
A comparative analysis of the products of GROEL-1 gene fromChlamydia trachomatisserovar D and the HSP60 var1 transcript fromHomo sapienssuggests a po…
2009
Summary Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.
Ontology-based service matching and discovery
2011
In this paper we consider ontologies as knowledge structures that specify attributes of services, their properties and relations among them to enable finding semantic similarity between service descriptions and service requests. Ontologies reflect semantic relationship between concepts represented by attributes in service descriptions and service requests. We use knowledge from ontologies to enhance the both user service requests and service descriptions by adding concepts that are not presented in the original descriptions, and use them in comparison process. It results in more precise matching since we consider also implicit concepts. Thus services and requests that do not contain exact m…
Evolution and functional differentiation of recently diverged phytochelatin synthase genes from Arundo donax L.
2019
Plant phytochelatin synthases undergo evolutionarily rapid functional differentiation after duplication, allowing fast and precise adjustment of metal detoxification capacity by modulation of both transcription and enzymatic activity.
Novel Combinatorial and Information-Theoretic Alignment-Free Distances for Biological Data Mining
2010
Among the plethora of alignment-free methods for comparing biological sequences, there are some that we have perceived as representative of the novel techniques that have been devised in the past few years and as being of a fundamental nature and of broad interest and applicability, ranging from combinatorics to information theory. In this chapter, we review these alignment free methods, by presenting both their mathematical definitions and the experiments in which they are involved in.
Advances in Strain Gauge Measurement on Composite Materials
2010
This article gives an overview on the application of strain gauge techniques to the analysis of the strains in composite materials. The orthotropic behaviour of the composite influences the performance of strain gauges that are calibrated for use on isotropic materials. The article considers therefore the typical topics of the strain gauge technology applied to composites with particular reference to the compensation of thermal output, the measurement of the coefficients of thermal expansion, the determination of the strain and stress state, the influence of the misalignment error, the reinforcement effect, the determination of the stress intensification factor, the analysis of residual str…
Learning Path Generation by Domain Ontology Transformation
2005
An approach to automated learning path generation inside a domain ontology supporting a web tutoring system is presented. Even if a terminological ontology definition is needed in real systems to enable reasoning and/or planning techniques, and to take into account the modern learning theories, the task to apply a planner to such an ontology is very hard because the definition of actions along with their preconditions and effects has to take into account the semantics of the relations among concepts, and it results in building an ontology of learning. The proposed methodology is inspired to the Knowledge Space Theory, and proposes some heuristics to transform the original ontology in a weig…
Epidemiological dynamics of norovirus GII.4 variant New Orleans 2009.
2015
Norovirus (NoV) is one of the major causes of diarrhoeal disease with epidemic, outbreak and sporadic patterns in humans of all ages worldwide. NoVs of genotype GII.4 cause nearly 80–90 % of all NoV infections in humans. Periodically, some GII.4 strains become predominant, generating major pandemic variants. Retrospective analysis of the GII.4 NoV strains detected in Italy between 2007 and 2013 indicated that the pandemic variant New Orleans 2009 emerged in Italy in the late 2009, became predominant in 2010–2011 and continued to circulate in a sporadic fashion until April 2013. Upon phylogenetic analysis based on the small diagnostic regions A and C, the late New Orleans 2009 NoVs circulati…
Multi-temporal and Multi-source Remote Sensing Image Classification by Nonlinear Relative Normalization
2016
Remote sensing image classification exploiting multiple sensors is a very challenging problem: data from different modalities are affected by spectral distortions and mis-alignments of all kinds, and this hampers re-using models built for one image to be used successfully in other scenes. In order to adapt and transfer models across image acquisitions, one must be able to cope with datasets that are not co-registered, acquired under different illumination and atmospheric conditions, by different sensors, and with scarce ground references. Traditionally, methods based on histogram matching have been used. However, they fail when densities have very different shapes or when there is no corres…