Search results for "alternative"

Effects of Plant Density on the Number of Glandular Trichomes and on Yield and Quality of Essential Oils from Oregano.

2016

Plants yields are influenced by agronomic techniques. Plant density is a complex issue and extremely important when maximizing both crop quality, and biomass and essential oil yields. Plants belonging to the Origanum vulgare subspecies hirtum (Link) Ietswaart were grown adopting four types of plant density and were characterized in biometric and chemical terms. The samples were analyzed using the ANOVA (Principal Component Analysis) statistical method regarding biometric aspects, EO yield and peltate hair density. Essential oil (EO) was extracted by hydrodistillation and analyzed using GC-FID and GC-MS. GC-FID and GC-MS analysis led to the identification of 45 compounds from the EO. Plant …

The European directive on traditional herbal medicinal products: friend or foe for plant-based therapies?

2012

Synthesis of Optically Pure Arylamine Derivatives by Using the Bucherer Reaction

2017

The Bucherer reaction is a common pathway for the conversion of 1- and 2-naphthols into the corresponding 1- or 2-naphthylamines, respectively. Mostly, only singular examples for its preparative use are reported since this particular transformation seems to be very sensitive to the reaction conditions. By choosing different phenolic substrates and chiral amines, we were able to prepare a broad scope of optically pure arylamines using this type of reaction. In contrast to alternative methods forming C−N aryl bonds such as Buchwald-Hartwig or Chan-Lam cross-coupling reactions, no palladium or copper catalysts are required. The use of water as solvent and the easily available starting material…

Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation.

2021

Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene expression. The identification of the actual splice sites and the proper removal of introns are essential for the production of the desired mRNA isoforms and their encoded proteins. While the basic mechanisms of splicing regulation are well understood, recent work has uncovered a growing number of noncanonical splicing mechanisms that play key roles in the regulation of gene expression. In this review, we summarize the current principles of splicing regulation, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, transcription, and RNA modifications. We f…

Quality of reporting in abstracts of RCTs published in emergency medicine journals: a protocol for a systematic survey of the literature

2017

Introduction The quality of reporting of abstracts of randomised controlled trials (RCTs) in major general medical journals and in some category-specific journals was shown to be poor before the publication of the ConsolidatedStandards of ReportingTrials (CONSORT) extension for abstracts in 2008, and an improvement in the quality of reporting of abstracts was observed after its publication. The effect of the publication of the CONSORT extension for abstracts on the quality of reporting of RCTs in emergency medicine journals has not been studied. In this paper, we present the protocol of a systematic survey of the literature, aimed at assessing the quality of reporting in abstracts of RCTs p…

Methodological aspects of clinical trials in tinnitus: a proposal for an international standard

2012

Abstract: Chronic tinnitus is a common condition with a high burden of disease. While many different treatments are used in clinical practice, the evidence for the efficacy of these treatments is low and the variance of treatment response between individuals is high. This is most likely due to the great heterogeneity of tinnitus with respect to clinical features as well as underlying pathophysiological mechanisms. There is a clear need to find effective treatment options in tinnitus, however, clinical trials differ substantially with respect to methodological quality and design. Consequently, the conclusions that can be derived from these studies are limited and jeopardize comparison betwee…

Future Research in Graves' Orbitopathy: From Priority Setting to Trial Design Through Patient and Public Involvement

2015

Graves' orbitopathy (GO) is a disfiguring autoimmune condition, which can sometimes cause blindness (1). The disease has profound effects on quality of life (2), psychological health (3), and socioeconomic status (4). Progress in understanding and treating this disease has been slow. However, recent advances include delineation of plausible immunological mechanisms (5), development of an animal model (6), and publication of randomized studies defining the role and limitations of intravenous steroids (7), rituximab (8,9), and selenium (10). Yet, some of this knowledge remains to be translated into improvement in clinical care. Access of patients to specialist treatments is patchy and seems t…

Exercise and Smoking : A Literature Overview

2015

The purpose of this review is to summarize the more recent research findings regarding the relationship between exercise and smoking behavior. Reviewed studies have been presented according to themes and research design types. Initially cross-sectional and longitudinal epidemiological studies have been reviewed in order to map findings regarding the correlations between those two behaviors. Moreover, studies exploring variables that function as mediators or moderators between smoking and exercise relationship have been included. Then studies examining the possible preventive effects of exercise on smoking behavior for adolescents are reviewed and implications for developing effective preven…

Scoping review and concept analysis of early adolescents’ emotional skills : Towards development of a music therapy assessment tool

2021

Introduction: This paper describes the concept and content of early adolescents’ emotional skills among the general population. The research literature contains many emotional skills-related terms with overlapping meanings, and it can be challenging to determine which are applicable for example, to a music therapy assessment tool. This study comprises the first phase of developing an assessment tool for early adolescents’ emotional skills, namely, determining what is to be assessed. Method: A scoping review of the literature is presented with written definitions of emotional skills-related terms, as well as a concept analysis of the terms performed using Walker and Avant’s method. Results: …

Music as a resource for psychological health for music professionals : A Nordic survey

2020

Purpose: Interest in the health relevance of music has been growing rapidly, yet few studies have addressed the protective role of music for music professionals themselves. In the current study, we investigated music professionals’ (music teachers, music therapists, musicians and academics) health, particularly their uses of music as a resource for their psychological health. Design: An online survey (N = 504) for music professionals was conducted across four Nordic countries. Participants responded to questions on music as a resource for psychological health and assessed their general levels of health and health behaviors. Their self-reported health was compared to similar prior data from …