Search results for "amer"

Barking at the Threshold

2019

Over the past few years, students of ancient Mediterranean societies have shown consistent interest in the cultural construction of dogs as reflected in texts, artefacts, and other media. However, whereas the cultural and literary implications of the Greek representation of dogs have been the subject of thorough investigations, Roman dogs have remained at the margins of the scholarly debate. By adopting an interdisciplinary methodology that combines cognitive theory, rhetorical analysis, and socio-anthropological research, the present paper discusses some affordances of dogs (in the terms of James Gibson’s 'ecological approach to visual perception') that are given special significance withi…

Role of RNA Motifs in RNA Interaction with Membrane Lipid Rafts: Implications for Therapeutic Applications of Exosomal RNAs

2021

RNA motifs may promote interactions with exosomes (EXO-motifs) and lipid rafts (RAFT-motifs) that are enriched in exosomal membranes. These interactions can promote selective RNA loading into exosomes. We quantified the affinity between RNA aptamers containing various EXO- and RAFT-motifs and membrane lipid rafts in a liposome model of exosomes by determining the dissociation constants. Analysis of the secondary structure of RNA molecules provided data about the possible location of EXO- and RAFT-motifs within the RNA structure. The affinity of RNAs containing RAFT-motifs (UUGU, UCCC, CUCC, CCCU) and some EXO-motifs (CCCU, UCCU) to rafted liposomes is higher in comparison to aptamers withou…

Binding of RNA Aptamers to Membrane Lipid Rafts: Implications for Exosomal miRNAs Transfer from Cancer to Immune Cells

2020

Intraluminal vesicles (ILVs) are released into the extracellular space as exosomes after the fusion of multivesicular bodies (MVBs) with the plasma membrane. miRNAs are delivered to the raft-like region of MVB by RNA-binding proteins (RBPs). RNA loading into exosomes can be either through direct interaction between RNA and the raft-like region of the MVB membrane, or through interaction between an RBP&ndash

Selection of Membrane RNA Aptamers to Amyloid Beta Peptide: Implications for Exosome-Based Antioxidant Strategies

2019

The distribution of amyloid beta peptide 42 (Aβ42) between model exosomal membranes and a buffer solution was measured. The model membranes contained liquid-ordered regions or phosphatidylserine. Results demonstrated that up to ca. 20% of amyloid peptide, generated in the plasma (or intracellular) membrane as a result of proteolytic cleavage of amyloid precursor proteins by β- and γ-secretases, can stay within the membrane milieu. The selection of RNA aptamers that bind to Aβ42 incorporated into phosphatidylserine-containing liposomal membranes was performed using the selection-amplification (SELEX) method. After eight selection cycles, the pool of RNA aptamers was isol…

Margara Russotto, Roman Hernandez. Laboratorio lombrosiano, Firenze, Centro Studi Eielson, 2012

2013

"Laboratorio lombrosiano" es un libro en el que literatura y ciencia dialogan, coincidiendo en un universo a la par caotico y ordenado, en el que el ser humano participa con soberano y libre albedrio.

Palabras para Rosina

2005

Puentes literarios: obras y traducciones. Una conversacion con Ofelia Huamanchuco de la Cuba

2019

es la entrevista a la escritora peruana Ofelia Huamanchumo sobre su obra literaria

Sigo casada con mi lengua materna. Entrevista a Ofelia Huamanchumo

2018

Es la entrevista a una joven escritora peruana, que vive en Alemania.

Mārtiņa Zīverta lugas “Pēdējā laiva” iepazīšanas iespējas vidusskolā

2022

Diplomdarbā “Mārtiņa Zīverta lugas “Pēdējā laiva” iepazīšanas iespējas vidusskolā”, tās interpretācija un analīze vidusskolas posmā mācību priekšmeta “Latvijas mācība” ietvaros tiek pētīta problēma, kā interpretēt un analizēt Mārtiņa Zīverta lugu “Pēdējā laiva” “Latvijas mācības” mācību priekšmeta ietvaros vidusskolā, īpaši izceļot eksistenciālisma iezīmes lugā. Diplomdarba teorētiskajā daļā tiek pētīta Mārtiņa Zīverta daiļrade un personība, kamerlugu žanra izveide, trimdas literatūra Latvijā un pasaulē, eksistenciālisms kā modernisma virziens latviešu un ārzemju literatūrā. Diplomdarba praktiskā daļa sastāv no anketēšanas un pedagoģiskās izmēģinājumdarbības. Anketēšanas ietvaros tiek apzin…

Friday Black et Intruders : lecture croisée au prisme de l'afrofuturisme

2022

This article contrasts “The Finkelstein 5” and “Zimmer Land”, from Nana Kwame Adjei Brenyah’s short story collection Friday Black (2018) with the “Untitled” series from Mohale Mashigo’s Intruders (2018), using Mark Dery’s definition of Afrofuturism as a reading grid and a starting point. While both collections draw on the codes of science fiction and dystopia to portray racialized characters in futuristic settings to examine their relation to technology and their place in fictional ‘future’ societies, they take on different approaches. The article concludes that Adjei-Brenyah’s writing, in Friday Black, leans towards what could be termed ‘Afropresentism’ based on François Hartog’s definitio…