Search results for "amine"

Galantamine permeation through buccal mucosa: studies on reconstituted human oral epithelium and porcine tissue

2008

Osallisuuden lisääminen : Habermasin kommunikatiivisen toiminnan teoriaa mukaillen

2017

Tämä filosofian alaan kuuluva tutkimus käsittelee osallisuutta ja sen lisäämistä peruskoulussa käyttäen menetelmänä Habermasin kehittämää kommunikatiivisen toiminnan teoriaa. Tutkimuksen tarkoituksena on tuoda esille osallisuus-käsitteen eri merkityssisältöjä ja esitellä menetelmä, jota soveltaen osallisuuden kokemista ja tunnetta osallisuudesta voidaan lisätä. Osallisuus, jota tässä opinnäytetyössä tutkitaan, nousi korostetusti esille vuoden 2014 Perusopetuksen opetussuunnitelman perusteissa mutta edellä mainituissa perusteissa ei tuotu tämän tutkimuksen tekijän mielestä esille, mitä osallisuus on tai miten sitä lisätään oppilaiden keskuudessa. Tässä tutkimuksessa tuodaan esille, että Habe…

Binge administration of 3,4-methylenedioxymethamphetamine ("ecstasy") impairs the survival of neural precursors in adult rat dentate gyrus.

2006

3,4-Methylenedioxymethamphetamine (MDMA) is a potent stimulant and hallucinogenic drug whose ability to regulate neurogenesis in the adult has not been previously investigated. We used 5'-bromo-2-deoxyuridine (BrdU) and Ki-67 as mitotic markers, and doublecortin (DCX) as a marker of immature neurons, to study proliferation, survival and maturation of adult-generated cells in the dentate gyrus (DG) of the hippocampus following binge administration of MDMA (8 injections of 5 mg/kg at 6 h intervals). The results showed that MDMA treatment did not affect cytogenesis in the DG, but significantly decreased the survival rate of cells incorporated after 2 weeks to the granular layer of the DG by ca…

Neurochemical substrates of the rewarding effects of MDMA: implications for the development of pharmacotherapies to MDMA dependence.

2015

In recent years, studies with animal models of reward, such as the intracranial self-stimulation, self-administration, and conditioned place preference paradigms, have increased our knowledge on the neurochemical substrates of the rewarding effects of 3,4-methylenedioxymetamphetamine (MDMA) in rodents. However, pharmacological and neuroimaging studies with human participants are scarce. Serotonin [5-hydroxytryptamine (5-HT)], dopamine (DA), endocannabinoids, and endogenous opiates are the main neurotransmitter systems involved in the rewarding effects of MDMA in rodents, but other neurotransmitters such as glutamate, acetylcholine, adenosine, and neurotensin are also involved. The most impo…

Could halophilic archaea improve the traditional salted anchovies (Engraulis encrasicholus L) manufacture?

2008

Although initial interest on extremely halophilic archaea turned to their involvement in the spoilage of salted meat and fish products, studies on the occurrence of such microorganisms in food ecosystems have rarely been performed. During salted anchovies production, a traditional process used by Mediterranean fishermen to obtain a tender product with a specific pleasant aroma and taste, extremely halophilic archaea belonging to the Halobacteriaceae family are often isolated. In order to elucidate the influence of halobacteria in salting and curing of this product, an experimental manufacturing was performed according to a traditional procedure. Salt to be employed was artificially inoculat…

Interaction Between Amines and N-Haloimides: a New Motif for Unprecedentedly Short Br...N and I...N Halogen Bonds

2011

The complexes of N-bromosuccinimide or N-iodosuccinimide with a halogen bond acceptor, either 1,4-diazabicyclo[2.2.2]octane (DABCO), hexamethylenetetramine (HMTA) or 1,3,5-triazine (TRZ), led to an unprecedentedly strong (CO)2N–X⋯N halogen bond synthon (X = Br or I) determined from crystal structures of [DABCO]·[NBS]22, [HMTA]·[NBS]22, [TRZ]·[NIS]22 and [HMTA]·[NIS]44. The Br⋯N distances with DABCO and with HMTA donors were 2.347 A and 2.414 A being remarkably shorter (31% and 29%) than the sum of the VDW radii of nitrogen and bromide atoms, respectively. The corresponding I⋯N distances with HMTA and TRZ were 2.549 A and 2.596 A (27.8% and 26.4% less than the sum of the VDW radii of N and I…

Breathing molecular crystals: halogen- and hydrogen-bonded porous molecular crystals with solvent induced adaptation of the nanosized channels

2012

Exceptionally strong (OC–)2N–I⋯N halogen bonding (XB) in a combination with CO⋯H–C hydrogen bonds (HB) between N-iodosuccinimide (NIS) and hexamethylenetetramine (HMTA) yielded a series of molecular crystals possessing large 1D channels. In each structure, HMTA was tetra-coordinated by four NIS molecules resulting in robust [HMTA]·[NIS]4 complexes where the observed I⋯N distances, ranging from 2.486 to 2.586 A, were remarkable shorter (from 29.6 to 26.7%) than the sum of the vdW radii of nitrogen and iodine atoms. Multiple CO⋯H–C HBs interconnected the [HMTA]·[NIS]4 complexes into the structures with flexible “breathing” host-channels. Three different host-channel structures, either oval or…

NI halogen bonding supported stabilization of a discrete pseudo-linear [I12]2− polyiodide

2015

Two different dicationic N-donors, based on the DABCO diamine, have been studied as templates for polyiodides. The results present a new strategy for polyiodide stabilization, which involves both N⋯I halogen bonding and cation–anion interactions. This is highlighted by the self-assembly of an unprecedented discrete pseudo-linear dodecaiodide species.

Effects of apomorphine on orienting reaction in the rat

2009

Aim of the research was to study the possible relationship between rapid apomorphine-induced modifications of midbrain dopaminergic neuron activity and rapid modifications of a motor response triggered by sensory stimuli (sensory-motor integration. Following apomorphine administration, ANOVA test revealed significant decrease of head turning latency and duration. A change on dopamine release, leading to an inhibition or facilitation of dopamine-mediated responses to environmental stimuli, may be hypothesized.

The Occurrence and Dietary Exposure Assessment of Mycotoxins, Biogenic Amines, and Heavy Metals in Mould-Ripened Blue Cheeses

2020

The occurrence and dietary exposure assessment of 16 mycotoxins, 6 biogenic amines (BAs), and 13 metallic elements in blue-veined cheeses (n = 46) is reported. Co-occurrence of mycophenolic acid (&le