Search results for "antico"
showing 10 items of 736 documents
The cryogenic anticoincidence detector for ATHENA-XMS: preliminary results from the new prototype
2012
ATHENA has been the re-scoped IXO mission, and one of the foreseen focal plane instrument was the X-ray Microcalorimeter Spectrometer (XMS) working in the energy range 0.3-10 keV, which was a kilo-pixel array based on TES (Transition Edge Sensor) detectors. The need of an anticoincidence (AC) detector is legitimated by the results performed with GEANT4 simulations about the impact of the non x-ray background onto XMS at L2 orbit (REQ. < 0.02 cts/cm2/s/keV). Our consortium has both developed and tested several samples, with increasing area, in order to match the large area of the XMS (64 mm2). Here we show the preliminary results from the last prototype. The results achieved in this work off…
Two-site ELISA for quantification of the terminal C5b-9 complement complex in plasma
1993
Abstract A quantitative ELISA procedure using monoclonal and polyclonal antibodies against neoantigens of the terminal C5b-9 complement complex has been developed. The ELISA was demonstrated to be both sensitive and reproducible. The normal range for C5b-9 determinations, defined as 2.5–97.5% interval of the values obtained in 76 healthy blood donors, was 3.12–10.3 AU/ml. The presence of rheumatoid factor did not affect the determination of C5b-9 as demonstrated by immunoabsorption studies.
Flow cytometric immunophenotyping: principles and pitfalls
1992
Within the last decade flow cytometry (FCM) has become an integral part of basic immunological research. Elaboration of this technology has been intensively stimulated by a rapidly growing sophistication in monoclonal antibody technology and vice versa. At present numerous applications are established that allow an increasingly detailed insight into the immune system, however, automation still must be considered the "cinderella of the arts". Thus, transition of this powerful approach from a basic to a routine clinical procedure is much more difficult than expected. Sufficient usage of flow cytometers still requires some knowledge of physics and its technical applications. Moreover, several …
Generation of monoclonal antibodies against human regulatory T cells.
2009
Abstract Natural CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) control the activation of the immune system and therefore have become a major area of research in immunology. The generation of monoclonal antibodies against human Tregs offers the possibility to discover novel Treg-specific or Treg-associated surface markers and to identify targets for a therapeutic modulation of Tregs. Here we present a methodology optimized to efficiently induce and select mAb against human Tregs by repeated immunization of mice with Tregs from a single donor and a differential two-step flow cytometry-based hybridoma screening procedure.
DALLA PUNIZIONE ALLA RIPARAZIONE? ASPIRAZIONI E LIMITI DELL’ENNESIMA RIFORMA ANTICORRUZIONE (LEGGE N. 69/2015)
2015
Il testo propone un commento critico delle norme anticorruzione contenute nella l. 69/2015. La tesi di fondo è che la dichiarata aspirazione a privilegiare una strategia riparatoria è in realtà smentita dal contenuto effettivo di molte delle norme introdotte, le quali mantengono invece un tenore saldamente punitivo.
Adjunctive Brivaracetam in Older Patients with Focal Seizures: Evidence from the BRIVAracetam add‑on First Italian netwoRk Study (BRIVAFIRST).
2022
BACKGROUND: The management of epilepsy in older adults has become part of daily practice because of an aging population. Older patients with epilepsy represent a distinct and more vulnerable clinical group as compared with younger patients, and they are generally under-represented in randomized placebo-controlled trials. Real-world studies can therefore be a useful complement to characterize the drug's profile. Brivaracetam is a rationally developed compound characterized by high-affinity binding to synaptic vesicle protein 2A and approved as adjunctive therapy for focal seizures in adults with epilepsy. OBJECTIVE: The aim of this study was to assess the 12-month effectiveness and tolerabil…
Chances and Problems of Cultural Anthropological Perspectives in Ancient Studies. Theories – Methods – Case Studies
2020
The Distant Worlds Journal (DWJ) is an online peer-reviewed journal established especially for presenting the research of early-career scholars on the ancient world. Each edition of the DWJ centres on a specific question or topic pertinent to the diverse disciplines engaged in the study of ancient cultures. In our fourth edition, we explore cultural anthropological theories and methods in the ancient studies, both in terms of the opportunities they offer for the study of ancient cultures and the problems they pose when applied.
Sex-based differences in outcomes with bivalirudin or unfractionated heparin for transcatheter aortic valve replacement: Results from the BRAVO-3 ran…
2016
Background Women comprise almost 50% of patients undergoing transcatheter aortic valve replacement (TAVR) and previous studies have indicated higher rates of procedural complications and bleeding in women compared to men. It is unknown whether men and women demonstrate a differential response to bivalirudin versus unfractionated heparin (UFH) in TAVR. We sought to evaluate outcomes by sex and type of anticoagulant from the Bivalirudin Versus Heparin Anticoagulation in Transcatheter Aortic Valve Replacement (BRAVO-3) trial of transfemoral TAVR. Methods BRAVO-3 was a randomized multicenter trial comparing transfemoral TAVR with bivalirudin versus UFH (31 centers, n = 802). The primary endpoin…
Early Bronze Age painted wares from Tell el-'Abd, Syria: A compositional and technological study
2018
Abstract The ‘Euphrates Monochrome Painted Ware’ (henceforth EMPW) is a ceramic style attested in the Middle Euphrates region in northern Syria at the beginning of the Early Bronze Age, ca. 2900–2700 BCE. This style is not an isolated phenomenon; rather, it must be understood in the context of a general, albeit short-lived, re-introduction of painted ceramics into local assemblages of Greater Mesopotamia. In the present study, we investigate the technology and provenance of the painted pottery from Tell el-'Abd (North Syria) and its relation to contemporary ceramics retrieved at this site. We apply a combination of macroscopic observations, ceramic petrography, and micro X-ray diffraction (…
Planning Punic cities: Geophysical prospection and the built environment at Motya, Sicily
2020
The urban plan of ancient Motya on the Isola di San Pantaleo on the west coast of Sicily and its relationship to developments in Phoenician and Punic societies have been investigated since the early 1960s. Data from geophysical surveys in the north-eastern quadrant of Motya show the regular organisation of urban insulae framed by two broad roads. These results, combined with data from previous nearby excavations, improve the modelling of Motya's layout, and contribute to the wider discussion of Phoenician/Punic and broader Mediterranean urban traditions between the sixth and fourth centuries BC.