Search results for "antimicrobial"
showing 10 items of 707 documents
Effect of cold drawing on the antimicrobial and physical properties of PCL/CHX monofilaments
2012
A synthetic derivative of antimicrobial peptide holothuroidin 2 from mediterranean sea cucumber (Holothuria tubulosa) in the control of Listeria mono…
2019
Due to the limited number of available antibiotics, antimicrobial peptides (AMPs) are considered antimicrobial candidates to fight difficult-to-treat infections such as those associated with biofilms. Marine environments are precious sources of AMPs, as shown by the recent discovery of antibiofilm properties of Holothuroidin 2 (H2), an AMP produced by the Mediterranean sea cucumber Holothuria tubulosa. In this study, we considered the properties of a new H2 derivative, named H2d, and we tested it against seven strains of the dangerous foodborne pathogen Listeria monocytogenes. This peptide was more active than H2 in inhibiting the growth of planktonic L. monocytogenes and was able to interf…
Effect of cholesterol on the interaction between amphyphylic peptides and liposomes
With the rise of antibiotic resistance, antimicrobial peptides (AMPs) have been proposed as an alternative novel class of therapeutic agents. They are polycationic, with a net positive charge of more than +2, and they are characterized by amphipathic structures, with both a hydrophobic and a hydrophilic domain. These characteristics allow them to selectively bind to negatively charged lipids (largely present in bacteria, not in mammalian cells), via hydrophobic and electrostatic interactions. Moreover, mammalian cells are characterized by a high content of cholesterol. For this reason, here we present an experimental study on the effect of the presence of cholesterol on the capability of am…
Staphylococcal Biofilms: Challenges in the discovery of Novel Anti-Infective Agents
2011
PVC silver zeolite composites with antimicrobial properties
2011
Poly(vinyl chloride) (PVC) composites containing increasing amounts (2-20%, w/w) of silver zeolite (SZ) were prepared by melt mixing and characterized by thermal, mechanical and rheological analyses. The addition of large amount of SZ did not influence the processability and the formability of the composites, if compared to neat plasticized PVC. The antibacterial activity of PVC SZ composites was tested on Escherichia coli and Staphylococcus epidermidis and resulted promising both in culture broth and on agar plate and also in sterile urine seeded with these strains, for simulation purposes. In sterile urine, composites induced a significant reduction (4-6 log units) of viability of both st…
Influence of Nisin on Photo-stability of EVA Antimicrobial Films
2010
Synthesis and Antimicrobial Activity of New 1,5-Dimethyl-3-Heteroaryl.1H-4-ONN-Azoxycyanides
2008
New Microbe Killers : Self-Assembled Silver(I) Coordination Polymers Driven by a Cagelike Aminophosphine
2019
New Ag(I) coordination polymers, formulated as [Ag(μ-PTAH)(NO3)2]n (1) and [Ag(μ-PTA)(NO2)]n (2), were self-assembled as light- and air-stable microcrystalline solids and fully characterized by NMR and IR spectroscopy, electrospray ionization mass spectrometry (ESI-MS(±), elemental analysis, powder (PXRD) and single-crystal X-ray diffraction. Their crystal structures reveal resembling 1D metal-ligand chains that are driven by the 1,3,5-triaza-7-phospaadamantane (PTA) linkers and supported by terminal nitrate or nitrite ligands; these chains were classified within a 2C1 topological type. Additionally, the structure of 1 features a 1D!2D network extension through intermolecular hydrogen bonds…
Synthesis, X-ray Crystal Structure and Antimicrobial Activity of Unexpected Trinuclear Cu(II) Complex from s-Triazine-Based Di-Compartmental Ligand v…
2019
The synthesis and X-ray crystal structure of the trinuclear [Cu3(HL)(Cl)2(NO3)(H2O)5](NO3)2 complex of the s-triazine-based di-compartmental ligand, 2-methoxy-4,6-bis(2-(pyridin-2-ylmsethylene)hydrazinyl)-1,3,5-triazine (H2L), are presented. The Cu1 and Cu2 are penta-coordinated with CuN3ClO coordination environment, distorted square pyramidal coordination geometry while Cu3 is hexa-coordinated with CuN2O4 coordination sphere, and distorted octahedral geometry. The complex crystallized in the primitive P-1 triclinic crystal system with two molecular units per unit cell. Its packing is dominated by the O–H (35.5%) and Cl–H (8.8%) hydrogen bonding interactions as well as the π–π stacking (2.3…
Antimikrobo līdzekļu menedžments stacionārā pnemonijas pacientiem
2019
Bakalaura darbs „Antimikrobo līdzekļu menedžments stacionārā pneimonijas pacientiem”. Tēmas aktualitāti nosaka elpošanas sistēmas saslimšanas gadījumu skaita palielināšanās, ar to saistīto antimikrobo līdzekļu lietošanas biežuma pieaugums un rezistento mikroorganismu attīstība. Darba mērķis ir noskaidrot antimikrobo līdzekļu menedžmenta realizāciju stacionārā pneimonijas pacientiem. Pētniecības metode – kvalitatīvā, instruments - intervija. Pētniecības jautājums: “Kā tiek realizēts antimikrobo līdzekļu terapijas menedžments pneimonijas pacientiem Intensīvās terapijas klīnikā?” Pētījuma rezultāti apliecina, ka Intensīvās terapijas klīnikā praktizējošās māsas izprot un īsteno antimikrobo līdz…