Search results for "aorta"
showing 10 items of 458 documents
The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features
2013
Abstract Background Vascular endothelial growth factors (VEGFs) are potential therapeutic agents for treatment of ischemic diseases. Their angiogenic effects are mainly mediated through VEGF receptor 2 (VEGFR2). Methods Receptor binding, signaling, and biological efficacy of several VEGFR2 ligands were compared to determine their characteristics regarding angiogenic activity and vascular permeability. Results Tested VEGFR2 ligands induced receptor tyrosine phosphorylation with different efficacy depending on their binding affinities. However, the tyrosine phosphorylation pattern and the activation of the major downstream signaling pathways were comparable. The maximal angiogenic effect stim…
Staphylococcus aureus alpha toxin mediates polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction.
2002
The effect of Staphylococcus aureus alpha toxin (alpha-toxin) on selectin-mediated neutrophil adhesion was investigated in polymorphonuclear leukocyte- (PMN) induced vasocontraction and endothelial dysfunction. Adherence of human PMNs to rat aortic endothelium increased significantly following stimulation of the endothelium with alpha-toxin (0.1, 0.5, and 1 microg/mL). This effect could be significantly attenuated by monoclonal antibodies directed against P-selectin or fucoidin, a carbohydrate known to block selectins. Unstimulated human PMNs (10(6)cells/mL) were added to organ chambers containing rat aortic rings stimulated with alpha-toxin (0.5 microg/mL). PMNs elicited a significant vaso…
Pro-inflammatory effects of interleukin-17A on vascular smooth muscle cells involve NAD(P)H- oxidase derived reactive oxygen species.
2010
T cells are known for their contribution to the inflammatory element of atherosclerosis. Recently, it has been demonstrated that the Th17 derived cytokine IL-17 is involved in the pro-inflammatory response of vascular smooth muscle cells (VSMC). The aim of the present study was to examine whether reactive oxygen species (ROS) might be involved in this context. The effect of IL-17A on ROS generation was examined using the fluorescent dye 2′7′-dichlorodihydrofluorescein (H<sub>2</sub>DCF) in primary murine VSMC. IL-17A induced an increase in H<sub>2</sub>DCF fluorescence in VSMC, and this effect was blocked by the NAD(P)H-oxidase inhibitor apocynin and siRNA targeting …
Ventricular-vascular coupling in hypertension: methodological considerations and clinical implications.
2014
The present review is addressed to analyse the complex interplay between left ventricle and arterial tree in hypertension. The different methodological approaches to the analysis of ventricular vascular coupling in the time and frequency domain are discussed. Moreover, the role of hypertension-related changes of arterial structure and function (stiffness and wave reflection) on arterial load and how ventricular-vascular coupling modulates the process of left ventricular adaptation to hypertension are analysed.The different interplay between vascular bed and left ventricle emerges as the pathophysiological basis for the development of the multiple patterns of ventricular structural adaptatio…
Comparison of Flow Measurement by 4D Flow Magnetic Resonance Imaging and by Particles Image Velocimetry on Phantom of Abdominal Aortic Aneurysm
2016
International audience; Predicting the rupture of Aortic Aneurysms is a complex problem that interests, from several decades, many researchers. The works on this issue are very complex, involving both the study of mechanical behavior of the artery as the flow of blood. The Magnetic Resonance Imaging (MRI) technique allows to obtain anatomic information of the arteries, than the flow inside thereof. The goal of this study is an inter comparison betweenflow data from MRI and those obtained by Particle Image Velocimetry (PIV). An experimental device simulating hemodynamic circulation is used. Initially in order to validate the device, the flow in a cylindrical glass tube is measured by these t…
Analysis of fluorescent MRI contrast agent behavior in the liver and thoracic aorta of mice.
2004
To characterize the behavior of magnetofluorescent products injected in mice intravenously.The magnetic resonance imaging (MRI) products were labelled with fluorescent molecules to examine the biodistribution process in vivo and observe them at the cellular level by means of confocal microscopy. Three-dimensional (3D) sequences of images were obtained by spectral analysis of sample preparations in a multiphoton confocal microscope and analyzed by the factor analysis of medical image sequence algorithm, which provides factor curves. Factor images are the result of image-processing methods that utilize information from emission spectra. Preparations are also screened in the counting mode to p…
Aprūpe intensīvās terapijas nodaļā pacientiem pēc akūtas operācijas sakarā ar abdominālās aortas aneirismas plīsumu
2017
Darba tēma: ‘’ Aprūpe pacientiem intensīvās terapijas nodaļā pēc akūtas operācijas sakarā ar abdominālās aortas aneirismas plīsumu ‘’ . Bakalaura darbs izstrādāts ar mērķi noskaidrot pacientu aprūpi intensīvās terapijas nodaļā pēc akūtas operācijas sakarā ar abdominālās aortas aneirismas plīsumu. Pētniecības jautājums ir - Kāda ir aprūpe intensīvās terapijas nodaļā pacientiem pēc akūtas operācijas sakarā ar abdominālās aortas aneirismas plīsumu? Pētniecības uzdevumi ir veikt literatūras analīzi par vēdera aortas aneirismu, izstrādāt kvalitatīvo pētījumu ar tā instrumentu – intervijas jautājumus, analizēt un apkopot iegūto informāciju, veikt secinājumus. Pētniecības darbs balstīts uz Dorotej…
Risultati a lungo termine. Confronto tra chirurgia tradizionale ed endovascolare.
2010
Arterial Aneurysms
2021
Aquest document ha estat revisat pel Servei de Política Lingüística de la Universitat de València en el context de la seva presentació als Premis Fernando Sapiña a material docent en valencià i anglès Classe per a estudiants de tercer curs del grau de Medicina. Assignatura Gr AR (34479): Pathology of the Cardiocirculatory system. Tema 23:Arterial Aneurysms Class for third year students of the bachelor's degree in Medicine. Subject Gr AR (34479): Pathology of the cardiocirculatory system. Unit 23: Arterial Aneurysms
Aneursimes arterials
2021
Aquest document ha estat revisat pel Servei de Política Lingüística de la Universitat de València en el context de la seva presentació als Premis Fernando Sapiña a material docent en valencià i anglès Classe per a estudiants de tercer curs del grau de Medicina. Assignatura Cr V (34479): Patologia de l'aparell cardiocirculatori. Tema 23: Aneurismes arterials Class for third year students of the Degree in Medicine. Subject Gr V (34479): Pathology of the cardiocirculatory system. Unit 23: Arterial aneurysms