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showing 10 items of 8586 documents
Predictors of Central Compartment Involvement in Patients with Positive Lateral Cervical Lymph Nodes According to Clinical and/or Ultrasound Evaluati…
2021
Lymph node neck metastases are frequent in papillary thyroid carcinoma (PTC). Current guidelines state, on a weak level of evidence, that level VI dissection is mandatory in the presence of latero-cervical metastases. The aim of our study is to evaluate predictive factors for the absence of level VI involvement despite the presence of metastases to the lateral cervical stations in PTC. Eighty-eight patients operated for PTC with level II–V metastases were retrospectively enrolled in the study. Demographics, thyroid function, autoimmunity, nodule size and site, cancer variant, multifocality, Bethesda and EU-TIRADS, number of central and lateral lymph nodes removed, number of positive lymph n…
Enhancing improvisational music therapy through the addition of resonance frequency breathing : Common findings of three single-case experimental stu…
2018
One core characteristic of active music therapy is the facilitation of emotional expression through the creation of music improvisations. In an attempt to further develop this approach, we created an enhanced form of integrative improvisational music therapy by including 10 minutes of resonance frequency breathing (RFB) at the beginning of the sessions. RFB is a type of slowbreathing known for its ability to reduce stress and support emotional regulation. This paper summarizes the common findings of three single-case experimental studies and introduces a provisional model to explain the observed effects of RFB. During the breathing itself, all three clients (two of them healthy and one diag…
Surgical and orthodontic rapid palatal expansion in adults using a modified palatal partial osteotomy technique (ppot): Technique description and cli…
2020
Transversal hypoplasia of the upper maxilla is a frequent condition between malocclusions. The rapid maxillary expansion (RME) is an already consolidated technique for these types of defects. This case report analyzes the outcome of a novel surgical technique that we named TOPP (Partial Palatal osteotomy technique) aiming to provide scientifically proven data over the percentage of relapse and the long-term stability of this type of surgical assisted palatal expansion. A 24 year old male patient with a hyperdivergent class III, presenting the absence of 1.1 due to a teenage trauma and a transversal contraction of the upper arch was selected for the surgery. The mucoperiosteal flap was perfo…
Induction of Type-Specific Neutralizing Antibodies by Capsomeres of Human Papillomavirus Type 33
2001
Abstract The immunogenicity of capsomeres of human papillomavirus type 33 was evaluated in a dose–response analysis. Capsomeres were obtained free of capsids by expression of L1 carrying the single point mutation C427S. Neutralizing antibodies were detected using an in vitro pseudoinfection assay. Capsomeres induced type-specific, neutralizing antibodies in mice even in the absence of adjuvant. The neutralization titers of immune sera raised without adjuvant were 10- to 20-fold lower than those of antisera to virus-like particles, but virtually identical using Freund's adjuvant. These data indicate that capsomeres may substitute for virus-like particles in future vaccines when used with an …
Novel cytokine-targeted therapies and intestinal inflammation
2009
Several cytokines have been identified as critical mediators of chronic inflammation in inflammatory bowel disease (IBD) and biological therapies that target these molecules have been developed during recent years. Thereby, anti-TNF agents have noticeably improved the treatment of patients with IBD in comparison to conventional therapy. Furthermore, initial clinical trials showed promising results with anti-IL-6 and anti-IL-12/IL-23 agents. In addition to these well-known mediators of IBD, various novel cytokines have been described as critical during the pathogenesis of IBD in recent experimental studies and therapeutic targeting of these cytokines could provide new strategies for human di…
Efficacy of Computer-Aided Static Navigation Technique on the Accuracy of Endodontic Microsurgery. A Systematic Review and Meta-Analysis
2021
The aim of this systematic review and meta-analysis was to analyze the efficacy of the computer-aided static navigation technique on the accuracy of root apex location in endodontic microsurgery. Material and Methods: A systematic literature review and meta-analysis, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, of clinical studies that evaluated the apex location rate of the computer-aided static navigation techniques applied to endodontic microsurgery. A total of four databases were consulted in the literature search: Pubmed-Medline, Scopus, Cochrane, and Web of Science. After eliminating duplicated articles and applying the inclusio…
Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria
2019
The mucosal surfaces of animals are habitat for microbes, including viruses. Bacteriophages—viruses that infect bacteria—were shown to be able to bind to mucus. This may result in a symbiotic relationship in which phages find bacterial hosts to infect, protecting the mucus-producing animal from bacterial infections in the process. Here, we studied phage binding on mucus and the effect of mucin on phage-bacterium interactions. The significance of our research is in showing that phage adhesion to mucus results in preventive protection against bacterial infections, which will serve as basis for the development of prophylactic phage therapy approaches. Besides, we also reveal that exposure to m…
Bronhiālās astmas ārstēšanai izmantojamo zāļu aprite dažādās Latvijas reģionu aptiekās 2016. gadā
2017
Bronhiālā astma ir plaši izplatīta slimība, kas skar vairāk nekā 30 miljonu cilvēku. Latvijā ar astmu slimo 1% iedzīvotāju. Šī darba mērķis bija noskaidrot bronhiālās astmas ārstēšanā izmantojamo medikamentozo terapiju atšķirības dažādās Latvijas reģionu aptiekās, balstoties uz Pasaules Astmas iniciatīvas organizācijas (GINA) 2016.gada izstrādātajām vadlīnijām. Tika iegūti rezultāti, ka astmas kontrolēšanai paredzēto medikamentu izvēle visās piecās aptiekās atbilst GINA 2016. gada izstrādātajām vadlīnijām.. Priekšroka visās aptiekās tiek dota IGK kombinācijā arβ2 agonistu grupas medikamentiem. Vispieprasītākais medikaments ir īsas darbības inhalējamais β2 agonists – salbutamols. Apstrādājot…
Agresijas risks un tā novēršanas paņēmieni narkoloģijas pacientu aprūpē
2021
Bakalaura darba tēma – „Agresijas risks un tā novēršanas paņēmieni narkoloģijas pacientu aprūpē” Tēmas aktualitāti nosaka fakts, ka vardarbības pārvaldība ir svarīgākais pasākums, strādājot ar potenciāli vardarbīgiem pacientiem narkoloģijā. Pētījuma hipotēze: Agresīvas uzvedības būtiskākie riska faktori ir ārējie stimuli, un par efektīvākiem agresijas risku novēršanas paņēmieniem tiek uzskatīti medikamentozās terapijas paņēmieni. Pētījuma mērķis: Noskaidrot agresijas risku un tā novēršanas paņēmienus narkoloģijas pacientu aprūpē. Pētījuma uzdevumi: 1.analizēt zinātnisko literatūru par narkoloģijas pacientu aprūpi, agresiju, tās riskiem un to novēršanu; 2.analizēt D. Oremas māszinības teorij…
Artrīta farmakoterapija - aptaujas rezultāti un zāļu vielu aprite Kamēlijas aptiekā 2014. - 2016. gadā
2016
Mūsdienās strauji pieaug cilvēku skaits, kurus skāris artrīts. Slimības attīstību ietekmē liekais svars, izmaiņas locītavās, pārmērīgas fiziskās aktivitātes, smaguma celšana darbā, kā arī traumas. Lai novērstu sekas un izmaiņas locītavās un kaulu struktūrā, ir svarīgi laicīgi uzsākt atbilstošu ārstēšanu, mazināt locītavu iekaisumu, stiprināt un saglabāt locītavu funkcijas. Darba mērķis: ar anketēšanas palīdzību izvērtēt artrīta ārstēšanas medikamentus, kas vislabāk palīdz pacientiem, un kādas papildus terapijas metodes pacienti izmanto, lai uzlabotu veselības stāvokli, kā arī noskaidrot artrīta zāļu apriti Kamēlijas aptiekā laika posmā no 2014. – 2016. gadam.