Search results for "apte"
showing 10 items of 222 documents
Data Compression Approach for Long-Term Monitoring of Pavement Structures
2019
Pavement structures are designed to withstand continuous damage during their design life. Damage starts as soon as the pavement is open to traffic and increases with time. If maintenance activities are not considered in the initial design or considered but not applied during the service life, damage will grow to a point where rehabilitation may be the only and most expensive option left. In order to monitor the evolution of damage and its severity in pavement structures, a novel data compression approach based on cumulative measurements from a piezoelectric sensor is presented in this paper. Specifically, the piezoelectric sensor uses a thin film of polyvinylidene fluoride to sense the ener…
3D Integration : towards high-performance innovative imaging sensors
2017
Nowadays, CMOS image sensors are almost exclusively architectured around analog pixels. A transition to purely digital pixels would significantly improve the performances of imagers. Unfortunately, such an approach is difficult to consider because it causes an oversized and unusable pixel for the consumer market. One of the promising ways to solve this problem of pixel integration is to think not only in 2D dimensions, but in 3D dimensions by distributing the different functionalities on several interconnected wafers.Thus, the work presented in this manuscript describes the design of a purely digital image sensor in CMOS 3D-IC 130 nm Tezzaron technology. This sensor is architectured around …
Fluxapyroxad Haptens and Antibodies for Highly Sensitive Immunoanalysis of Food Samples
2017
Fluxapyroxad is a new-generation carboxamide fungicide, with residues increasingly being found in food samples. Immunochemical assays have gained acceptance in food quality control as rapid, cost-effective, sensitive, and selective methods for large sample throughput and in situ applications. In the present study, immunoreagents to fluxapyroxad were obtained for the first time, and competitive immunoassays were developed for the sensitive and specific determination of fluxapyroxad residues in food samples. Two carboxyl-functionalized analogues of fluxapyroxad were prepared, and antibodies with IC50 values in the low nanomolar range were generated from both haptens, though a dissimilar respo…
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
2013
Author version made available in accordance with the publisher's policy.
Mid-infrared supercontinuum generation in chalcogenide and telluride fibers for sensor devices
2019
This thesis reports on the progress made during my PhD concerning supercontinuum generation and its application in two types of materials: chalcogenide and tellurite glasses. Concerning the chalcogenide axis, two new arsenic-free compositions are developed: Ge20Se60Te20 and Ge20Se70Te10. Thermal and optical properties of these two glasses are studied and two types of fibers are manufactured: a step-index fiber and a suspended core fiber. The generation of supercontinuum in these two fibres, pumped by an optical parametric amplifier, gives competitive results compared to the current state of the art of supercontinuum generation in chalcogenide fibres. Supercontinuums widening between 2 and 1…
Antibody generation and immunoassay development in diverse formats for pyrimethanil specific and sensitive analysis
2012
Immunochemical techniques are complementary tools to modern analytical requirements. These methods rely on the production of immunoreagents with adequate binding properties. In the present study, a rationally designed and functionalized derivative of pyrimethanil-a modern anilinopyrimidine fungicide-was synthesized in order to generate for the first time high-affinity and selective antibodies to this xenobiotic. A single coupling procedure-based on hapten activation using N,N′-disuccinimidyl carbonate and purification of the active ester-was followed to prepare both immunizing and assay conjugates. Polyclonal antibodies were produced and characterized by enzyme-linked immunosorbent assay (E…
Identification and characterisation of the dopamine receptor II from the cat flea Ctenocephalides felis (CfDopRII)
2006
International audience; G protein-coupled receptors (GPCRs) represent a protein family with a wide range of functions. Approximately 30% of human drug targets are GPCRs, illustrating their pharmaceutical relevance. In contrast, the knowledge about invertebrate GPCRs is limited and is mainly restricted to model organisms like Drosophila melanogaster and Caenorhabditis elegans. Especially in ectoparasites like ticks and fleas, only few GPCRs are characterised. From the cat flea Ctenocephalides felis, a relevant parasite of cats and dogs, no GPCRs are known so far. Thus, we performed a bioinformatic analysis of available insect GPCR sequences from the honeybee Apis mellifera, the mosquito Anop…
Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo
2012
Increasing evidence suggests that antibodies can have stimulatory effects on T-cell immunity. However, the contribution of circulating antigen-specific antibodies on MHC class I cross-priming in vivo has not been conclusively established. Here, we defined the role of circulating antibodies in cross-presentation of antigen to CD8(+) T cells. Mice with hapten-specific circulating antibodies, but naϊve for the T-cell antigen, were infused with haptenated antigen and CD8(+) T-cell induction was measured. Mice with circulating hapten-specific antibodies showed significantly enhanced cross-presentation of the injected antigen compared with mice that lacked these antibodies. The enhanced cross-pre…
Combating Illicit Trade in Cultural Objects to Defend Peace and Security
2022
This chapter analyzes the emergence of the heritage-security nexus as a new priority in the international protection and security agenda with a focus on the threats associated with the illicit trade of cultural objects originating from conflict-ridden territories. First, it offers an overview of the existing legal framework protecting cultural objects from looting during armed conflict. It then considers how the protection of cultural property has evolved from a humanitarian law issue to one that is tied to the maintenance of international peace and security. In this latter regard, it outlines the growing concern and activity of the UN Security Council in respect of cultural heritage, inclu…
Capitolo VIII della Carta dell’ONU e modelli di azione militare regionale
2019
This contribution deals with relations between regional organizations and the UN Security Council under Chapter VIII of the UN Charter. In this respect, the most recent trends are a shift from subsidiarity to a more equal partnership between these two subjects. The two models of action by delegation or authorization of the Security Council are in fact autonomous. This is demonstrated by the preparatory works of the UN Charter and subsequent practice. The model of authorized regional action enriches the range of instruments that the United Nations Charter provides for the maintenance of peace and collective security.