Search results for "asma"
showing 10 items of 4204 documents
The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS
2007
Membrane fission is an essential process in membrane trafficking and other cellular functions. While many fissioning and trafficking steps are mediated by the large GTPase dynamin, some fission events are dynamin independent and involve C-terminal-binding protein-1/brefeldinA-ADP ribosylated substrate (CtBP1/BARS). To gain an insight into the molecular mechanisms of CtBP1/BARS in fission, we have studied the role of this protein in macropinocytosis, a dynamin-independent endocytic pathway that can be synchronously activated by growth factors. Here, we show that upon activation of the epidermal growth factor receptor, CtBP1/BARS is (a) translocated to the macropinocytic cup and its surroundi…
Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors.
1999
The assembly of signalling molecules into macromolecular complexes (transducisomes) provides specificity, sensitivity and speed in intracellular signalling pathways. Rod photoreceptors in the eye contain an unusual set of glutamic-acid-rich proteins (GARPs) of unknown function. GARPs exist as two soluble forms, GARP1 and GARP2, and as a large cytoplasmic domain (GARP' part) of the beta-subunit of the cyclic GMP-gated channel. Here we identify GARPs as multivalent proteins that interact with the key players of cGMP signalling, phosphodiesterase and guanylate cyclase, and with a retina-specific ATP-binding cassette transporter (ABCR), through four, short, repetitive sequences. In electron mic…
Il cappero di Linosa: aspetti colturali e individuazione di biotipi spontanei per utilizzazioni produttive
2008
Linosa, isola dell'arcipelago delle Pelagie, vanta un'antica tradizione agricola basata su sistemi colturali tradizionali legati a poche colture agrarie (ortive, vite, cappero, ecc.). Per salvaguardare e valorizzare tali produzioni, il Consorzio Co.Ri.S.S.I.A. di Palermo ha intrapreso uno studio sul cappero linosano (Capparis spinosa L. subsp. rupestris). La prova è stata condotta somministrando schede-questionario ad un campione rappresentativo di produttori di cappero locali unitamente ad indagini esporative sul territorio. Sono state individuate 7 accessioni di cappero su cui sono stati condotti rilievi morfo-biometrici e produttivi. In questo lavoro si riportano i risultati delle schede…
Germoplasma di cultivar siciliane di nocciolo conservato dall’Orto Botanico di Palermo
2009
Recupero e caratterizzazione delle accessioni di ciliegio (Prunus avium l.) del germoplasma autoctono della calabria
2011
Innovazione varietale, genotipi tradizionali e qualità dei frutti nella melicoltura siciliana
2019
L’obiettivo di questo lavoro è stato quello di valutare, dal punto di vista pomologico e sensoriale, varietà di melo tradizionali e nuovi cloni, entrambi coltivati nel territorio collinare siciliano. Più precisamente abbiamo studiato le performance qualitative di mele del germoplasma siciliano e quello di frutti provenienti da programmi di innovazione varietale che ancora sono in via di osservazione per una eventuale diffusione sul territorio nell’ambito di progetti ministeriali specifici (Farina et al., 2009; Gregori et al., 2015). Lo studio si è basato su analisi chimico-fisiche e panel test applicate alla raccolta commerciale.
Effects of military training on plasma amino acid concentrations and their associations with overreaching.
2020
Amino acids are thought to have a key role in the processes contributing to overreaching development through their metabolic properties and neuronal functions. In the present study, the effects of 10-week military training on the concentrations of 19 amino acids were investigated. Plasma amino acid concentrations were measured at rest from 53 healthy male conscripts on weeks 1, 4, 7, and 9 of their military service. Conscripts were classified as overreached and non-overreached. Overreaching classification was based on fulfilling at least three of five criteria: greater than 5% decrease in maximal oxygen uptake, increased rating perceived exertion (RPE), and decreased lactate-RPE ratio in s…
Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.
2010
Abstract The clinical relevance of angiopoietin-2 (Ang2) in chronic lymphocytic leukemia (CLL) was previously suggested by the association between high Ang2, and shorter progression-free survival reported in small series of patients. Here, we evaluated Ang2 glycoprotein levels in plasma samples collected from a multicentric cohort of CLL patients (n = 316) using an enzyme-linked immunosorbent assay method, and we investigated its prognostic role in relation to time to first treatment (TTFT) and overall survival. Based on a cutoff equal to 2459 pg/mL, we divided our cohort in 2 subsets (high and low Ang2) composing 100 (31.6%) and 216 (68.4%) patients, respectively. High Ang2 was predictive …
Degradation of Antibiotic Vancomycin by UV Photolysis and Pulsed Corona Discharge Combined with Extrinsic Oxidants
2023
Antibiotics are the most frequently detected pharmaceuticals in the environment creating conditions for the development of resistant genes in bacteria. Degradation and mineralization of glycopeptide antibiotic vancomycin (VMN) were examined by UV photolysis, pulsed corona discharge (PCD), and their combinations with extrinsic oxidants, hydrogen peroxide (HP), peroxydisulfate (PDS), and peroxymonosulfate (PMS). Both combinations were effective in VMN degradation and faster at pH 11 than in acidic or neutral media. Combined with the UV photolysis, HP showed a higher oxidation rate than other oxidants, whereas PMS and PDS proved to be more efficient in combinations with PCD. In contrast to low…
The rare isotope beams production at the Texas A&M university Cyclotron Institute
2013
The Cyclotron Institute at Texas A&M is currently configuring a scheme for the production of radioactive-ion beams that incorporates a light-ion guide and a heavy-ion guide coupled with an electron-cyclotron-resonance ion source constructed for charge-breeding. This scheme is part of an upgrade to the facility and is intended to produce radioactive beams suitable for injection into the K500 superconducting cyclotron. The current status of the project and details on the ion sources used in the project is presented. peerReviewed