Search results for "beta"
showing 10 items of 3374 documents
Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a n…
2007
Abstract Toll IL-1R 8/single Ig IL-1-related receptor (TIR8/SIGIRR) is a member of the IL-1R family, expressed by epithelial tissues and immature dendritic cells, and is regarded as a negative regulator of TLR/IL-1R signaling. Tir8-deficient mice were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis, despite controlling efficiently the number of viable bacilli in different organs. Tir8−/−-infected mice showed an increased number of neutrophils and macrophages in the lungs; however, mycobacteria-specific CD4 and CD8 T cells were similar in Tir8−/− and Tir8+/+ mice. Exaggerated mortality of Tir8−/− mice was due to massive liver necrosis and was accompanie…
CCL3 and CCL4, the Major Chemokines Produced by CD38+ Chronic Lymphocytic Leukemia Cells, Facilitate Microenvironmental Interactions of Neoplastic Ce…
2008
Abstract CD38, a negative prognostic marker for patients with CLL, has been demonstrated to be a key molecule in the interactions occurring in the context of tumor microenvironment, mediating both survival and migratory signals for CLL cells. By taking advantage of gene expression profiling studies (GEP) comparing 11 CD38pos (CD38>30%) and 15 CD38neg (CD38<10%) CLLs, we identified as over-expressed in CD38pos CLL cells: i) genes for the two C-C chemokines CCL3 and CCL4 (median-log difference, MLD-CCL3= 3.5; MLD-CCL4=4.4); real-time quantitative PCR (RTQ-PCR) of selected cases confirmed GEP results; ii) the gene for CD49d (MLD=4.4); a high correlation between CD38 and CD49d pro…
Pythium stipitatumsp. nov. isolated from soil and plant debris taken in France, Tunisia, Turkey, and India
2009
Pythium stipitatum is a slow-growing oomycete and has been isolated from soil samples and plant materials from France, Tunisia, Turkey and India. Its morphological characteristics are reminiscent of those of Pythium ramificatum, discovered in Algeria by the corresponding author. Unfortunately, the Algerian isolate was not deposited in any culture collection and ultimately got lost. Those were the days when molecular description of fungi was not a fashion; hence, no molecular characteristics of the Algerian isolates were deposited to the GenBank. Moreover, its coralloid antheridial branches made it an easy prey to be considered as synonymous to Pythium minus. Because there are no living stra…
Analysis of β2-agonists in cattle hair samples using a rapid UHPLC–ESI–MS/MS method
2016
A simple and efficient method was developed for simultaneous analysis of five illegal residual β2-agonists in cattle hair. β2-Agonists were quantified by ultra high performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry operating in positive multiple-reaction monitoring mode. The method was validated as quantitative confirmatory method according to the EU Decision 2002/657/EC: instrumental linearity, specificity, precision, recovery, decision limit (CCα) and detection capability (CCβ) were evaluated. The recovery were greater than 90% and the method appeared suitable for the control of these β2-agonists in cattle hair samples with LOQ values between …
Determinación de la actuación de los bloqueadores beta adrenérgicos sobre la vasodilatación producida por las catecolaminas en la microcirculación de…
2021
La rosácea es una entidad cuya fisiopatología no es bien conocida, por lo que su tratamiento es inespecífico. Sin embargo, recientes estudios han demostrado que existe una disregulación neurovascular en esta entidad, por ello, existe una necesidad de comprender mucho mejor las vías moleculares que controlan la vasodilatación permanente de los pequeños vasos cutáneos (alrededor de 200 μm) y la inflamación. A modo de resumen, el sistema simpático es el modulador primario de la vasculatura cutánea, con multitud de adrenorreceptores identificados que incluyen los α1, α2, β1y β2. La disregulación del sistema nervioso simpático en la rosácea ha tenido una considerable atención, como la modulación…
Nuevas medidas de emisión de neutrones en la desintegración beta de 85Ge, 85-86As, 91Br, 135Sb, 137-138Te y 138-139-140I
2023
En esta Tesis he determinado de forma experimental la probabilidad de emisión de neutrones en la desintegración β de los núcleos 85Ge,85,86As,91Br,135Sb, 137,138Te y 138,139,140I para los que las medidas previas mostraban errores relativamente altos y/o una gran dispersión. Estos núcleos son de interés 1) en tecnología nuclear, para cálculos de dinámica y control de reactores, 2) en astrofísica nuclear, para cálculos de la abundancia de elementos químicos pesados en el proceso de captura rápida de neutrones, y 3) en el estudio de la estructura de núcleos ricos en neutrones. Así, en este trabajo el énfasis se ha puesto en la mejora de las medidas y el análisis de los datos. Por ello se selec…
Antioxidant betalains from cactus pear (Opuntia ficus-indica) inhibit endothelial ICAM-1 expression.
2004
It has been suggested that some pigments would have antioxidant properties and that their presence in dietary constituents would contribute to reduce the risk of oxidative stress–correlated diseases. Among others, inflammatory response depends on redox status and may implicate oxidative stress. Vascular endothelial cells are a direct target of oxidative stress in inflammation. We have tested the impact of the free radical scavenger and antioxidant properties of betalains from the prickle pear in an in vitro model of endothelial cells. Here we show the capacity of betalains to protect endothelium from cytokine- induced redox state alteration, through ICAM-1 inhibition. KEYWORDS: endothelial …
Phytoestrogens increase the capacity of serum to stimulate prostacyclin release in human endothelial cells
2003
Both the estrogen receptor (ER) alpha and beta isoforms are expressed in the endothelium. The ER beta has been assigned a crucial role in normal vascular wall function. Prostacyclin has been ascribed a beneficial effect on vessel wall physiology. Isoflavones bind with higher affinity to ER beta. We investigated the hypothesis that their administration to postmenopausal women can promote endothelial prostacyclin production.Twenty-five healthy postmenopausal women with mild climacteric symptoms received capsules containing 55 mg/day isoflavones derived from soy and red clover for 6 months. Cultured human umbilical vein endothelial cells (HUVECs) were exposed for 24 h to serum collected before…
On achieving near-optimal “Anti-Bayesian” Order Statistics-Based classification fora asymmetric exponential distributions
2013
Published version of a Chapter in the book: Computer Analysis of Images and Patterns. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-40261-6_44 This paper considers the use of Order Statistics (OS) in the theory of Pattern Recognition (PR). The pioneering work on using OS for classification was presented in [1] for the Uniform distribution, where it was shown that optimal PR can be achieved in a counter-intuitive manner, diametrically opposed to the Bayesian paradigm, i.e., by comparing the testing sample to a few samples distant from the mean - which is distinct from the optimal Bayesian paradigm. In [2], we showed that the results could be extended for a few sym…
“Anti-Bayesian” parametric pattern classification using order statistics criteria for some members of the exponential family
2013
This paper submits a comprehensive report of the use of order statistics (OS) for parametric pattern recognition (PR) for various distributions within the exponential family. Although the field of parametric PR has been thoroughly studied for over five decades, the use of the OS of the distributions to achieve this has not been reported. The pioneering work on using OS for classification was presented earlier for the uniform distribution and for some members of the exponential family, where it was shown that optimal PR can be achieved in a counter-intuitive manner, diametrically opposed to the Bayesian paradigm, i.e., by comparing the testing sample to a few samples distant from the mean. A…