Search results for "beta"
showing 10 items of 3374 documents
First Accurate Normalization of the β-delayed α Decay of ^{16}N and Implications for the ^{12}C(α,γ)^{16}O Astrophysical Reaction Rate.
2018
The ^{12}C(α,γ)^{16}O reaction plays a central role in astrophysics, but its cross section at energies relevant for astrophysical applications is only poorly constrained by laboratory data. The reduced α width, γ_{11}, of the bound 1^{-} level in ^{16}O is particularly important to determine the cross section. The magnitude of γ_{11} is determined via sub-Coulomb α-transfer reactions or the β-delayed α decay of ^{16}N, but the latter approach is presently hampered by the lack of sufficiently precise data on the β-decay branching ratios. Here we report improved branching ratios for the bound 1^{-} level [b_{β,11}=(5.02±0.10)×10^{-2}] and for β-delayed α emission [b_{βα}=(1.59±0.06)×10^{-5}].…
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
2021
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…
Systematic approach to β and 2vββ decays of mass A=100-136 nuclei
2015
In this work we perform a systematic study of pairs of single-β-decaying nuclei in the mass region A = 100–136 to extract information on the effective value of the axial-vector coupling constant gA. As the many-body framework we use the quasiparticle random-phase approximation (QRPA) and its proton-neutron variant (pnQRPA) in singleparticle valence bases with Woods-Saxon-calculated single-particle energies. It is found that, to a reasonable approximation, gA is a linear function of the mass number A, with a slightly different parametrization below and above the mass A = 121. Using the values of gA extracted from the linear fit, as well as an average constant value of gA, we calculate the tw…
The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.
2014
β-Catenin is a central effector of the Wnt pathway and one of the players in Ca(+)-dependent cell-cell adhesion. While many wnts are present and expressed in vertebrates, only one β-catenin exists in the majority of the organisms. One intriguing exception is zebrafish that carries two genes for β-catenin. The maternal recessive mutation ichabod presents very low levels of β-catenin2 that in turn affects dorsal axis formation, suggesting that β-catenin1 is incapable to compensate for β-catenin2 loss and raising the question of whether these two β-catenins may have differential roles during early axis specification. Here we identify a specific antibody that can discriminate selectively for β-…
Latest results from CUPID-0
2022
International audience; CUPID-0 is a pilot experiment in scintillating cryogenic calorimetry for the search of neutrino-less double beta decay. 26 ZnSe crystals were operated continuously in the first project phase (March 2017 - December 2018), demonstrating unprecedented low levels of background in the region of interest at the Q-value of $^{82}\rm{Se}$. From this successful experience comes a demonstration of full alpha to beta/gamma background separation, the most stringent limits on the $^{82}\rm{Se}$ neutrino-less double beta decay, as well as the most precise measurement of the $^{82}$Se half-life. After a detector upgrade, CUPID-0 began its second and last phase (June 2019 - February…
Copulation duration, but not paternity share, potentially mediates inbreeding avoidance in Drosophila montana
2014
Studying the incidence of inbreeding avoidance is important for understanding the evolution of mating systems, especially in the context of mate choice for genetic compatibility. We investigated whether inbreeding avoidance mechanisms have evolved in the malt fly, Drosophila montana, by measuring mating latency (a measure of male attractiveness), copulation duration, days to remating, offspring production, and the proportion of offspring sired by the first (P1) and second (P2) male to mate in full-sibling and unrelated pairs. SNP markers were used for paternity analysis and for calculating pairwise relatedness values (genotype sharing) between mating pairs. We found 18 % inbreeding depressi…
IL-13 induced beta2-adrenergic receptor (beta2-AR) desensitization in human airway epithelial cells.
2013
Increased Gamma Connectivity in the Human Prefrontal Cortex during theBereitschaftspotential
2017
The Bereitschaftspotential (BP) is a slow negative cortical potential preceding voluntary movement. Since movement preparation is dependent upon the synchronous activity of a variety of neurons, BP may develop through the exchange of information among motor-related neurons. However, the relationship between BP and information flow is not yet well-known. In the present study, we aimed to investigate how the connectivity in the prefrontal cortex (PFC) changes during the occurrence of BP. Electrocorticography (ECoG) was recorded in five patients with epilepsy. The subjects performed self-paced hand grasping. We compared the intraregional connectivity between PFC and non-PFC regions using parti…
Understanding the Role of Sensorimotor Beta Oscillations
2021
Beta oscillations have been predominantly observed in sensorimotor cortices and basal\ud ganglia structures and they are thought to be involved in somatosensory processing\ud and motor control. Although beta activity is a distinct feature of healthy and pathological\ud sensorimotor processing, the role of this rhythm is still under debate. Here we review\ud recent findings about the role of beta oscillations during experimental manipulations (i.e.,\ud drugs and brain stimulation) and their alteration in aging and pathology. We show how\ud beta changes when learning new motor skills and its potential to integrate sensory input\ud with prior contextual knowledge. We conclude by discussing a n…