Search results for "beta"
showing 10 items of 3374 documents
Measurement of the double-beta decay half-life and search for the neutrinoless double-beta decay of Ca48 with the NEMO-3 detector
2016
The NEMO-3 experiment at the Modane Underground Laboratory investigates the double-beta decay of Ca48. Using 5.25 yr of data recorded with a 6.99 g sample of Ca48, approximately 150 double-beta decay candidate events are selected with a signal-to-background ratio greater than 3. The half-life for the two-neutrino double-beta decay of Ca48 is measured to be T2ν1/2=[6.4+0.7−0.6(stat)+1.2−0.9(syst)]×1019 yr. A search for neutrinoless double-beta decay of Ca48 yields a null result, and a corresponding lower limit on the half-life is found to be T0ν1/2>2.0×1022 yr at 90% confidence level, translating into an upper limit on the effective Majorana neutrino mass of ⟨mββ⟩<6.0–26 eV, with the rang…
Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77.
2012
The major capsid proteins VP16 and VP17 of bacteriophage P23-77 have been crystallized using both recombinant and purified virus and preliminary diffraction analyses have been performed.
Populärmusik från Vittula - en skildring av livet i Pajala på 1960- och 1970-talen
2005
Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications
2018
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriages. However, the exact mechanisms involved in the clinical manifestations of the syndrome are still a matter of investigation. In particular, while vascular thrombosis is apparently not associated with inflammation, the pathogenesis of miscarriages can be explained only in part by the aPL-mediated hypercoagulable state and additional non-thrombotic effects, including placental inflammation, have b…
Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias
2018
γδ T lymphocytes are potent effector cells, capable of efficiently killing tumor and leukemia cells. Their activation is mediated by γδ T-cell receptor (TCR) and by activating receptors shared with NK cells (e.g., NKG2D and DNAM-1). γδ T-cell triggering occurs upon interaction with specific ligands, including phosphoantigens (for Vγ9Vδ2 TCR), MICA-B and UL16 binding protein (for NKG2D), and PVR and Nectin-2 (for DNAM-1). They also respond to cytokines undergoing proliferation and release of cytokines/chemokines. Although at the genomic level γδ T-cells have the potential of an extraordinary TCR diversification, in tissues they display a restricted repertoire. Recent studies have identified …
Interleukin 10 restores lipopolysaccharide-induced alterations in synaptic plasticity probed by repetitive magnetic stimulation
2020
Systemic inflammation is associated with alterations in complex brain functions such as learning and memory. However, diagnostic approaches to functionally assess and quantify inflammation-associated alterations in synaptic plasticity are not well-established. In previous work, we demonstrated that bacterial lipopolysaccharide (LPS)-induced systemic inflammation alters the ability of hippocampal neurons to express synaptic plasticity, i.e., the long-term potentiation (LTP) of excitatory neurotransmission. Here, we tested whether synaptic plasticity induced by repetitive magnetic stimulation (rMS), a non-invasive brain stimulation technique used in clinical practice, is affected by LPS-induc…
Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities.
2017
Ruta chalepensis L. (Rutaceae) leaf extract was investigated for its chemical profile and antioxidant and hypoglycaemic properties. The antioxidant effects were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), Chi-carotene bleaching, and metal chelating activity assays. The carbohydrate-hydrolysing enzymes inhibition assay was used to test the hypoglycaemic potential. R. chalepensis showed a high content of hesperidin and rutin with values of 591.9 and 266.7 mg/g dry extract, respectively. The extract exhibited a promising protection of lipid peroxidation (IC50 value of 16.9 mu g/mL) and inhibited both alpha-amylase and alpha-glucosidase enzymes in a concentration-dependent manner. The…
Propranolol - stary lek i nowe zastosowania w leczeniu naczyniaków
2019
Naczyniaki niemowlęce (IH) są najczęstszym guzami naczyniowym u najmłodszych dzieci i dotyczą około 5% do 10% populacji niemowląt. W przeciwieństwie do innych guzów, ich ewolucja obejmuje fazę szybkiego wzrostu, fazę stabilizacji, a następnie charakteryzuje się fazą powolnego, samoistnego zaniku. Najczęściej nie stanowią potencjalnego zagrożenia dla zdrowia niemowląt i nie wymagają terapii, ale w niektórych przypadkach (10-15%) konieczne jest niezwłocznie rozpoczęcie leczenia ogólnoustrojowego. Powyższe odnosi się do IH, które mogą powodować niewydolność krążenia lub niewydolność oddechową, stwarzać ryzyko zaburzeń czynnościowych niektórych narządów, np. ucisk gałki ocznej i niedowidzenie l…
Análisis molecular de la valoración del intervalo de tiempo óptimo entre la administración de acetato de triptorelina y la punción folicular en los t…
2023
Los fármacos análogos de la GnRH y la hCG han demostrado ser igualmente eficaces en la activación de la cascada de intermediarios de la maduración final ovocitaria que ocurre tras el estímulo ovulatorio. Sin embargo, su mecanismo de acción y por tanto los perfiles hormonales hallados tras el estímulo de los dos fármacos son muy diferentes. El tiempo más adecuado para programar la recolección ovocitaria tras la administración de acetato de triptorelina podría no ser 36 horas como ampliamente se ha pautado en los tratamientos de FIV con hCG. Este intervalo de tiempo es sumamente importante para obtener la mayor proporción posible de ovocitos MII porque procesos como el inicio de la luteinizac…
Lipase-catalyzed resolution of β-hydroxy selenides
2006
Abstract Eleven β-hydroxy selenides were kinetically resolved using an immobilized lipase (Amano PS-C II) in toluene in the presence of vinyl acetate at 30 °C. This approach provided, in several cases, both enantiomers in high enantiomeric excess. The role of the size of substituents and the behaviour of cyclic β-hydroxy selenides is also discussed. Enantiopure β-hydroxy selenides are useful building blocks. As an application of this chemistry, enantiopure (1 S ,2 R )-indene oxide was obtained in one step from the proper enantiopure β-hydroxy selenide.