Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities.

6533b824fe1ef96bd12814be

RESEARCH PRODUCT

Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities.

Rosa Tundis Monica Rosa Loizzo Vincenzo Sicari Marco Bonesi Tiziana Falco Maurizio Bruno

subject

leave Metal chelating activity Antioxidant DPPH medicine.medical_treatment Rutin HPLC analysi antioxidant activity Plant Science 01 natural sciences Biochemistry Antioxidants Analytical Chemistry Lipid peroxidation Rutin chemistry.chemical_compound Hesperidin Enzyme Inhibitor Enzyme Inhibitors Traditional medicine biology Hydrolysis beta Carotene Ruta chalepensis Antioxidant Plant Leave hypoglycaemic activity Plant Extract alpha-Amylase Inhibitory Concentration 50 Picrates Ruta chalepensi Botany medicine Glycoside Hydrolase Inhibitors Glycoside Hydrolase Inhibitor Ruta Dose-Response Relationship Drug 010405 organic chemistry Plant Extracts Hesperidin Organic Chemistry Biphenyl Compounds Settore CHIM/06 - Chimica Organica biology.organism_classification Hydrolysi 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Rutaceae chemistry Biphenyl Compound Picrate Lipid Peroxidation alpha-Amylases

description

Ruta chalepensis L. (Rutaceae) leaf extract was investigated for its chemical profile and antioxidant and hypoglycaemic properties. The antioxidant effects were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), Chi-carotene bleaching, and metal chelating activity assays. The carbohydrate-hydrolysing enzymes inhibition assay was used to test the hypoglycaemic potential. R. chalepensis showed a high content of hesperidin and rutin with values of 591.9 and 266.7 mg/g dry extract, respectively. The extract exhibited a promising protection of lipid peroxidation (IC50 value of 16.9 mu g/mL) and inhibited both alpha-amylase and alpha-glucosidase enzymes in a concentration-dependent manner. The highest activity was found against alpha-amylase (IC50 value of 69.0 mu g/mL). The obtained results support the use of R. chalepensis leaves as healthy food ingredients.

year	journal	country	edition	language
2017-05-10	Natural product research

10.1080/14786419.2017.1326491 https://pubmed.ncbi.nlm.nih.gov/28486828

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