Search results for "bicarbonate"
showing 10 items of 119 documents
Dependence of plasma pH on oxygen saturation
1969
Abstract The influence of haemoglobin oxygenation on the pH value of the blood plasma of healthy adolescents was investigated at 38°C by varying the parameters CO2 pressure, Hb concentration and buffer bases. A total of 5000 measurements gave the following results: 1. 1. The pHs difference between oxygenated and deoxygenated blood increases with diminishing CO2 pressure and with increasing Hb concentration. There is a linear relation between the pHs changes and the O2 saturation of the haemoglobin. 2. 2. Quantitatively these relationships can be expressed by the following equation: δpHs = (8 − pH ox − log 0.03 Pco 2 ) · [Hb] 225 · (100 − So 2 100 where ΔpHs is the pHs difference between par…
Assessment of Usability of Thermal Bicarbonate Mineral Water from the “Odra-5/I” Intake in Grabin Opole Silesia (SWPoland) for Therapeutic and Prophy…
2020
Szczawy termalne należą do poszukiwanych surowców balneologicznych. Ten rodzaj wód jest cennym tworzywem wykorzystywanym w uzdrowiskach w szeroko rozumianej strategii zdrowotnej - profilaktyce i rekreacji. Odkrycie w 1983 r. szczawy termalnej w Grabinie koło Opola nastąpiło przypadkiem przy okazji wykonania odwiertu do rozpoznania budowy geologicznej krystalicznego podłoża osadów mezozoicznych i kenozoicznych. Występujące w Grabinie szczawy termalne są na obszarze bloku przedsudeckiego zjawiskiem unikalnym. Skład chemiczny, a zwłaszcza duża sumaryczna zawartość soli mineralnych wód z Grabina, wskazuje na niespotykany w skali kraju typ wody mineralnej. Zawartość składników stałych jest w nie…
Assessment of Usability of Thermal Bicarbonate Mineral Water from the “Odra-5/I” Intake in Grabin Opole Silesia (SW Poland) for Therapeutic and Proph…
2020
Thermal bicarbonate mineral water belong to sought-after balneological resources. This kind of water are a balneological product and valuable raw material used in health resorts for the wider health strategy - prophylaxis and recreation. The discovery of thermal bicarbonate mineral water in Grabin near Opole in 1983 was purely incidental when a intake was made for the recognition of the geological structure of the crystalline basement of Mesozoic and Cenozoic sediments. Thermal bicarbonate mineral water existing in Grabin can be found in the Fore-Sudetic block and is a unique phenomenon. Its chemical composition, and especially high total mineral salt content of the waters from Grabin, indi…
Point-of-care evaluation of a rapid antigen test (CLINITESTⓇ Rapid COVID-19 Antigen Test) for diagnosis of SARS-CoV-2 infection in symptomatic and as…
2021
AbstractRapid antigen assays (RAD) based on lateral flow immunochromatography (LFIC) technology have emerged as a valuable tool for the control of COVID-19 pandemic. Manufacturer□independent, real□world evaluation of these assays is crucial given the considerable heterogeneity reported in their clinical and analytical performances. Here, we report for the first time on the point-of-care performance of the CLINITEST® Rapid COVID-19 Antigen Test (Siemens, Healthineers, Erlangen, Germany) to detect SARS-CoV-2 infection in presumptive COVID-19 cases or asymptomatic close contacts of COVID-19 patients. When compared to RT-PCR, the overall sensitivity of the assay was 80.2 (95% CI, 70.9-87.1) for…
Experimental assessment of reverse electrodialysis in closed loop configuration fed by NH4HCO3-water solutions
2018
Closed loop reverse electrodialysis is a novel technology for converting low-temperature waste heat into electric energy. This innovative heat engine consists of two units: (i) a reverse electrodialysis unit where power is produced exploiting the concentration difference between a diluted and a concentrated salt solution and (ii) a thermally driven regeneration unit where low-grade waste heat is used to re-establish the original salinity gradient between the two salt solutions. Among all the possible salt solutions suitable as working fluid in such application, Thermolytic salts solutions, in particular Ammonium bicarbonate solutions, may be promising thanks to their characteristic thermall…
NH4HCO3–water solutions regeneration in RED closed loop applications
2017
Reverse Electrodialysis (RED) in closed loop arrangement (Reverse Electrodialysis Heat Engine - REDHE) is a promising technology to convert low-grade waste heat into electricity. RED is a membrane process exploiting the salinity gradient between a concentrated and a diluted solution to generate electrical current. Due to the transfer phenomena occurring in the RED unit, the two exiting solutions are partially mixed. Thermal regeneration processes can be used to restore the initial conditions of the two solutions, thus closing the loop. In this regard, ammonium hydrogen carbonate (NH4HCO3) salt solutions are suitable for such applications, being able to decompose at temperatures above 40-45 …
Nonenzymatic Transformation of Amorphous CaCO3 into Calcium Phosphate Mineral after Exposure to Sodium Phosphate in Vitro: Implications for in Vivo H…
2015
Studies indicate that mammalian bone formation is initiated at calcium carbonate bioseeds, a process that is driven enzymatically by carbonic anhydrase (CA). We show that amorphous calcium carbonate (ACC) and bicarbonate (HCO3 (-) ) cause induction of expression of the CA in human osteogenic SaOS-2 cells. The mineral deposits formed on the surface of the cells are rich in C, Ca and P. FTIR analysis revealed that ACC, vaterite, and aragonite, after exposure to phosphate, undergo transformation into calcium phosphate. This exchange was not seen for calcite. The changes to ACC, vaterite, and aragonite depended on the concentration of phosphate. The rate of incorporation of phosphate into ACC, …
In vitro prediction of in vivo absorption of ibuprofen from suspensions through rational choice of dissolution conditions
2020
Two ibuprofen suspension formulations were investigated for their dissolution in various bicarbonate, phosphate and acetate buffers. Phosphate and acetate gave faster release than bicarbonate at comparable molarities. Nevertheless, mass transport modelling using the reversible non-equilibrium (RNE) approach enabled the calculation of phosphate molarities that gave good matches to physiological bicarbonate in terms of ibuprofen dissolution. This shows that developing surrogate buffers for bicarbonate that are devoid of the technical difficulties associated with the bicarbonate-CO2 systems is possible. In addition, the intestinal dissolution kinetics of the tested suspensions were determined …
Strikingly High Respiratory Quotients: A Further Characteristic of the Tumor Pathophysiome
2008
Conspicuously high respiratory quotients (RQs) are found in solid tumors in vivo. RQs in the range between 1.29 and 1.95 neither reflect the degree of substrate oxidation by tumor cells nor indicate the types of fuels involved in metabolic processes. Instead, such tumor RQs most probably are caused by (a) channeling of glycolytic end-products into lipogenesis, and by (b) CO2 release from the tumor following extracellular buffering of H+ -inos by bicarbonate. H+ -inos exported from the intracellular space into the interstitial compartment titrate extracellular bicarbonate to CO2 and H2O with the aid of the ectoenzyme carbonic anhydrase IX, which is activated at low pH. Strikingly high (RQs) …
Protein Tyrosine Nitration Induced by Heme/Hydrogen Peroxide: Inhibitory Effect of Hydroxycinnamoyl Conjugates
2006
The present study was designed to optimize the experimental conditions that govern the heme-catalyzed nitration of protein tyrosine residues by nitrite, and, within this framework, to study the effects of 3,5-dicaffeoylquinic acid and its methyl ester, both of which have been previously reported to be antioxidants and inhibitors of leukocyte functions. Although the presence of hydrogen peroxide is essential in cell-free systems, an excess of this compound was found to be detrimental, so much so that an increase in hemin concentration actually resulted in an inverse effect on the reaction, depending on the levels of fixed hydrogen peroxide. Unlike previous reports on nitrite-induced albumin …