Search results for "breast"
showing 10 items of 1871 documents
Rho GTPases are over-expressed in human tumors.
1999
Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Efficacy of the Cognitively-Based Compassion Training (CBCT®) Program for the improvement of Quality of Life and Fear of Cancer Recurrence in a sampl…
2018
Existe un vasto cuerpo de investigación que evalúa los efectos de las intervenciones psicosociales sobre la adaptación psicológica durante el tratamiento del cáncer (Antoni, 2013; Guo et al., 2013; Stanton, 2006; Stanton, Luecken, MacKinnon y Thompson, 2013). En entornos oncológicos, las intervenciones basadas en Mindfulness han demostrado su eficacia para promover el bienestar y los dominios de calidad de vida (Sinatra y Black, 2018; Zainal, Booth y Huppert, 2013), estrategias de afrontamiento constructivas frente al estrés psicosocial relacionado con la enfermedad, aliviando la ansiedad, el estrés, la fatiga, el estado de ánimo general, la alteración del sueño (Carlson et al., 2003; Carls…
Early development of hedonic and motivational aspects of eating behaviour
2015
Eating is essential for survival. However, the newborn is not an autonomous eater, and has to learn ‘how', ‘what', ‘when', and ‘how much' to eat quickly enough to ensure harmonious growth and development. In other nutritional areas, it has been shown during the past 20 years that early experiences are likely to impact long-term health outcomes. Thus, it appears fundamental to understand the early development of hedonic and motivational aspects of eating behaviour. This presentation will describe several studies conducted in our group during the past 10 years, in order to gain more knowledge about the development of what and how much children eat, in relation with food sensory and nutritiona…
HER-2 marķiera noteikšana krūts vēža pacientēm neoadjuvantas ķīmijterapijas laikā
2021
Ievads. Onkomarķieriem ir īpaša nozīme ļaundabīgo slimību diagnostikā un ārstēšanas efektivitātes prognozēšanā. HER-2 receptora ekspresija raksturīga vidēji 15-30% krūts vēža audzējiem un ir saistīta ar agresīvu audzēja gaitu. Audzēja HER-2 ekspresiju nosaka biopsijas materiālā. Savukārt, ekstracelulāro HER-2 domēnu iespējams noteikt asins serumā. Seruma HER-2 var būt noteikts arī veseliem pacientiem, taču, tā koncentrācija ir augstāka pacientiem ar krūts vēzi, īpaši ja audzējs ir HER-2 receptoru pozitīvs. Izteikts seruma HER-2 koncentrācijas samazinājums ķīmijterapijas laikā var būt saistīts ar labāku atbildi uz terapiju, ilgāku laiku līdz slimības progresijai un garāku kopējo dzīvildzi. D…
"Evaluating the prognostic role of serum extracellular domain (ECD) of HER-2/neu (s-HER2) in patients (PTS) with early (E) breast cancer (BC)”
2009
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
2012
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
2013
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Relaciones suelo-vegetación en una toposecuencia del Escudo Guayanés, Venezuela
2014
El Escudo Guayanés es uno de los territorios más antiguos del planeta; tiene millones de años sometido a procesos de lixiviación y erosión que dejan suelos oligotróficos. El objetivo de este trabajo fue hacer la caracterización de los parámetros físicos y químicos de los suelos, en diferentes comunidades boscosas de la Reserva Forestal Imataca, e identificar ciertas relaciones entre los componentes edáficos y las especies que allí se presentan. Se realizó un inventario de todos los individuos mayores a 10cm dap (diámetro a la altura del pecho) en 15 parcelas (1ha); en cada una de esas parcelas se evaluaron cuatro sub-parcelas de sotobosque (100m²) para contabilizar todas las espermatofitas;…