Search results for "bulb"

Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons

1998

In the present study, we demonstrate that choline, a precursor of acetylcholine (ACh) and a product of acetylcholine hydrolysis by acetylcholinesterase (AChE), acts as an efficient and relatively selective agonist of alpha7-containing nicotinic acetylcholine receptors (nAChR) in neurons cultured from the rat hippocampus, olfactory bulb and thalamus as well as in PC12 cells. Choline was able to activate postsynaptic and presynaptic alpha7 nAChRs, with the latter action resulting in the release of other neurotransmitters. Although choline was approximately one order of magnitude less potent than ACh (EC50 of 1.6 mM for choline and 0.13 mM for ACh), it acted as a full agonist at alpha7 nAChRs.…

Effetti della concimazione sulla qualità dell'aglio coltivato in Sicilia

2009

Effetti della concimazione sulla qualità dell'aglio coltivato in Sicilia. Effects of fertilization on the quality of garlic grown in Sicily.

2010

In order to expand this crop and to improve bulbs quality a study was carried out to evaluate different fertilization techniques. Four fertilization formulas were evaluated: 1) mineral fertilization commonly used by Paceco producers - pre-planting with 55, 110 and 80 kg ha-1 of N, P2O5 and K2O - post planting with 47 and 46 kg ha-1 of N and K2O; 2) organic fertilization with an organic mix - pre-planting with 320 and 240 kg ha-1 of N and P2O5; 3) mineral fertilization - pre-planting with 40, 70 and 100 kg ha-1 of N, P2O5 and K2O - post-planting with 80 kg ha-1 of N half at 3-4 leaves and half at bulbs formation; 4) only post-planting fertilization with 52 and 184 kg ha-1 of N and K2O, half …

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

2021

LRP1-targeted St-Cl–polyglutamate conjugates as multivalent neuroprotective/neurotrophic therapeutics for Alzheimer’s disease.

Mean Radiant Temperature Measurements through Small Black Globes under Forced Convection Conditions

2021

One of the most critical variables in the field of thermal comfort measurements is the mean radiant temperature which is typically measured with a standard 150 mm black globe thermometer. This is also the reference instrument required for the assessment of heat stress conditions by means of the well-known Wet Bulb Globe Temperature index (WBGT). However, one of the limitations of this method is represented by the relatively long response time. This is why in recent years there has been a more and more pressing need of smart sensors for controlling Heating Ventilation and Air Conditioning (HVAC) systems, and for pocket heat stress meters (e.g., WBGT meters provided with table tennis balls). …

Soluble guanylyl cyclase appears in a specific subset of periglomerular cells in the olfactory bulb

2005

In the brain, nitric oxide acts as an atypical messenger in cellular nonsynaptic transmission. In the olfactory bulb, this gas is produced at the level of the olfactory glomeruli by a subpopulation of periglomerular cells that participates in the first synaptic relay of the olfactory information between the olfactory nerve and the dendritic tufts of principal cells. It has been proposed that nitric oxide modulates intraglomerular synaptic integration of sensory inputs, but its specific role in the glomerular circuitry remains to be understood. In this article, we demonstrate that, in the glomerular circuits, a specific subset of periglomerular cells, most of them expressing the calcium bind…

VIP-containing deep short-axon cells of the olfactory bulb innervate interneurons different from granule cells

2003

This study investigates the targets of the population of vasoactive intestinal polypeptide (VIP)-containing deep short-axon cells of the rat olfactory bulb (OB), combining single- and double-immunocytochemical approaches under light and electron microscopy. It has been assumed that deep short-axon cells innervate granule cells in the mammalian OB, but their synaptic connectivity has not been demonstrated to date. Our results indicate that, instead of the accepted scheme of the bulbar circuitry, VIP-containing deep short-axon cells are gamma-aminobutyric acid (GABA)ergic interneurons specialized in the selective innervation of other GABAergic deep short-axon cells. Their axons contact with t…

Symmetric expansion of neural stem cells from the adult olfactory bulb is driven by astrocytes via WNT7A.

2012

Adult neural stem cells (NSCs) located in the subventricular zone (SVZ) persistently produce new neurons destined to the olfactory bulb (OB). Recent research suggests that the OB is also a source of NSCs that remains largely unexplored. Using single/dual-labeling procedures, we address the existence of NSCs in the innermost layers of the OB. In vivo, these cells are more quiescent that their SVZ counterparts, but after in vitro expansion, they behave similarly. Self-renewal and proliferation assays in co-culture with niche astrocytes indicate that OB-glia restricts NSC activity whereas SVZ-glia has the opposite effect. Gene expression profiling identifies WNT7A as a key SVZ-glial factor lac…

Nicotinic receptor function in the mammalian central nervous system.

1995

The diversity of neuronal nicotinic receptors (nAChRs) in addition to their possible involvement in such pathological conditions as Alzheimer's disease have directed our research towards the characterization of these receptors in various mammalian brain areas. Our studies have relied on electrophysiological, biochemical, and immunofluorescent techniques applied to cultured and acutely dissociated hippocampal neurons, and have been aimed at identifying the various subtypes of nAChRs expressed in the mammalian central nervous system (CNS), at defining the mechanisms by which CNS nAChR activity is modulated, and at determining the ion permeability of CNS nAChR channels. Our findings can be sum…

Adult-derived neural precursors transplanted into multiple regions in the adult brain

1999

Neural stem cells persist in the adult brain subventricular zone (SVZ). These cells generate a large number of new neurons that migrate to the olfactory bulb, where they complete their differentiation. Here, we transplanted cells carrying beta-galactosidase under the control of neuron-specific enolase promoter (NSE::LacZ) from the SVZ of adult mice into the striatum cortex and olfactory bulb, with or without an excitotoxin lesion. Between 2 and 8 weeks after transplantation, grafted cells were present in the recipient regions, but extensive migration and differentiation into mature neurons of grafted cells were only observed in the olfactory bulb. Clusters of graft-derived neuroblasts formi…