Search results for "cART"
showing 10 items of 2010 documents
Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteobla…
2011
Osteoarthritis (OA) is a chronic degenerative joint disease showing altered bone metabolism. Osteoblasts contribute to the regulation of cartilage metabolism and bone remodeling. We have shown previously that induction of heme oxygenase-1 (HO-1) protects OA cartilage against inflammatory and degradative responses. In this study, we investigated the effects of HO-1 induction on OA osteoblast metabolism. HO-1 was induced with cobalt protoporphyrin IX (CoPP) and by transduction with LV-HO-1. In osteoblasts stimulated with interleukin (IL)-1β, CoPP enhanced mineralization, the expression of a number of markers of osteoblast differentiation such as Runx2, bone morphogenetic protein-2, osteocalci…
Epidemiology of multiple sclerosis in Sicily
2001
From epidemiological data obtained over more than 20 years by surveys conducted in different parts of Sicily, it is evident that Sicily is a high-risk area for multiple sclerosis (MS). This is in sharp contrast with the gradient hypothesis. High frequencies have been found in different parts of the island having different geoclimatic features, but at least two cities (Monreale and Enna) had had a prolonged Norman domination. This is in agreement with the hypothesis that MS originated in Northern Europe and spread around the world throughout the raids of the northern peoples. The increase in frequency estimated by follow-up and incidence studies is well established and is only in part linked…
Composite graft: a simple option for nasal lining.
2007
Background We present our experience in the reconstruction of full-thickness losses of the substance of the nose using a forehead flap and a composite graft (taken from the anterior surface of the concha and adequately shaped) as both support and endonasal lining. This technique has never been described for the reconstruction of large full-thickness losses of the substance of the nose. The donor site of the composite graft in the concha is repaired by a Masson retroauricular flap. Methods This technique was used on 14 patients (age range, 52–92 years) after full-thickness excision of tumors of the distal third of the nose. Follow-up was from 1 to 4 years. All the composite grafts were rev…
LACTATE, NOT GLUCOSE, UP-REGULATES MITOCHONDRIAL OXYGEN CONSUMPTION BOTHIN SHAM AND LATERAL FLUID PERCUSSED RAT BRAINS
2006
OBJECTIVE: Failure of energy metabolism after traumatic brain injury may be a major factor limiting outcome. Although glucose is the primary metabolic substrate in the healthy brain, the well documented surge in tissue lactate after traumatic brain injury suggests that lactate may provide an energy need that cannot be met by glucose. We hypothesized, therefore, that administration of lactate or the combination of lactate and supraphysiological oxygen may improve mitochondrial oxidative respiration in the brain after rat fluid percussion injury. We measured oxygen consumption (VO2) to determine what effects glucose, lactate, oxygen, and the combination of lactate and oxygen have on mitochond…
Different Surgical Approaches to Treat Chronic Tophaceous Gout in the Hand: Our Experience
2010
Chronic tophaceous gout is a disabling erosive arthritis characterized by an elevated serum urate concentration, recurrent attacks of arthritis, and deposits of monosodium urate crystals in synovial fluids. Tophi, ulcerations of the overlying skin, and fissures of the interarticular cartilage may occur in advanced stages, combined with deformities of the joints and decreased active joint flexion and extension. Although the timely use of allopurinol is associated with a decrease in the frequency of deposits of the tophaceous substance, however, surgical management is necessary to restore and improve the cosmesis and joint function, to alleviate symptomatic discomfort, and to reduce the risk …
The comparison of knee osteoarthritis treatment with single-dose bone marrow-derived mononuclear cells vs. hyaluronic acid injections
2017
Objective: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. Materials and methods: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren– Lawrence stage II–III osteoarthritis during the 12-month period were performed. The results were compared with the control group treated routinely by hyaluronic acid injections…
A stalactite record of four relative sea-level highstands during the Middle Pleistocene Transition
2017
International audience; Ice-sheet and sea-level fluctuations during the Early and Middle Pleistocene are as yet poorly understood. A stalactite from a karst cave in North West Sicily (Italy) provides the first evidence of four marine inundations that correspond to relative sea-level highstands at the time of the Middle Pleistocene Transition. The speleothem is located ∼97 m above mean sea level as result of Quaternary uplift. Its section reveals three marine hiatuses and a coral overgrowth that fixes the age of final marine ingression at 1.124 ± 0.2, thus making this speleothem the oldest stalactite with marine hiatuses ever studied to date. Scleractinian coral species witness light-limited…
Innovation in retail: influence of ICT and its impact on customer satisfaction
2017
espanolEn la literatura se ha definido tradicionalmente el concepto “innovacion” como aspecto necesario para el desarrollo economico y competitivo de las empresas y/o industrias, considerando esta como un determinante primordial para la creacion de riqueza y crecimiento de las economias. Con este trabajo se pretende llevar a cabo una aproximacion al concepto “innovacion en el comercio minorista”, identificando su naturaleza y alcance, y definiendo vinculos con variables de larga tradicion en la investigacion en marketing como los beneficios y costes de la relacion, la satisfaccion percibida de los consumidores y la lealtad hacia el establecimiento. Se propone un modelo teorico que se invest…
Angels carrying crowns on the images of martyrs. Origin of the iconographic type
2013
Este artículo pretende explicar el origen de las imágenes de los ángeles portando coronas a los mártires, señalando para ello la relación de las coronas con los mártires desde la época paleocristiana, cómo éstas empezaron a ser portadas por ángeles, y los diferentes tipos de coronas que pueden portar según las distintas épocas. This article tries to explain the origin of the images of angels carrying crowns to the martyrs; to this end, it points out the relationship of the crowns with the martyrs from Early Christian period, the way these crowns began to be carried by angels, and the different types of crowns they could carry depending on different periods.
Dibujando una nueva cartografía de la colonialidad Sur-Norte en época de crisis: la reproducción de la episteme y el estilo de vida europeo en las mi…
2018
El artículo analiza la migración de cualificados españoles a los espacios de Educación Superior ecuatoriana desde 2010 a 2016, con el objetivo de entender la experiencia de movilidad cualificada española hacia Ecuador. Para ello se ha utilizado una metodología cualitativa a través de entrevistas semiestructuradas a españoles y ecuatorianos que trabajan en los espacios de la Educación Superior. Además, se ha complementado con encuestas online autoadministradas y con observación participante. Se concluye que entre España y Ecuador se han creado espacios de circularidad promovidos por un contexto de crisis económica en España y por una gran inversión en la Educación Superior ecuatoriana. Sin e…