Search results for "cache"
showing 10 items of 79 documents
Pathophysiologic quantities of endotoxin-induced tumor necrosis factor-alpha release in whole blood from patients with chronic heart failure.
2002
Bacterial endotoxin activity is elevated in patients with decompensated chronic heart failure (HF) and acts as a potent stimulus for immune activation. We sought to determine whether endotoxin, at an activity level seen in vivo (around 0.6 EU/ml), is sufficient to stimulate the secretion of tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha soluble receptor (sTNFR2) in ex vivo whole blood from patients with HF. We studied 15 patients with HF (aged 65 +/- 1.9 years, New York Heart Association class 2.1 +/- 0.3, left ventricular ejection fraction 31 +/- 5%; mean +/- SEM), of whom 5 had cardiac cachexia, and 7 healthy control subjects (59 +/- 5 years, p = NS). Reference endotoxin was added …
Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery
2021
Frailty is the major expression of accelerated aging and describes a decreased resistance to stressors, and consequently an increased vulnerability to additional diseases in elderly people. The vascular aging related to frail phenotype reflects the high susceptibility for cardiovascular diseases and negative postoperative outcomes after cardiac surgery. Sarcopenia can be considered a biological substrate of physical frailty. Malnutrition and physical inactivity play a key role in the pathogenesis of sarcopenia. We searched on Medline (PubMed) and Scopus for relevant literature published over the last 10 years and analyzed the strong correlation between frailty, sarcopenia and cardiovascular…
Web Usage Mining by Neural Hybrid Prediction with Markov Chain Components
2021
This paper presents and evaluates a two-level web usage prediction technique, consisting of a neural network in the first level and contextual component predictors in the second level. We used Markov chains of different orders as contextual predictors to anticipate the next web access based on specific web access history. The role of the neural network is to decide, based on previous behaviour, whose predictor’s output to use. The predicted web resources are then prefetched into the cache of the browser. In this way, we considerably increase the hit rate of the web browser, which shortens the load times. We have determined the optimal configuration of the proposed hybrid predictor on a real…
MUSCLE WASTING AND CARDIAC MUSCLE DAMAGE IN CACHECTIC PATIENTS
2013
Muscle wasting is a degeneration of the muscle tissue that can derive from several patho-logical situations, but most of the times is caused by a condition of cachexia in patients with cancer or other diseases. This degeneration results from a decrease in protein syn-thesis and an increase in protein degradation. This is caused mainly by the overexpres-sion of ubiquitin-proteosome-system (UPS) elements, under the control of factors re-leased in cachexia that lead cells toward a catabolic rather than an anabolic pathway. Both skeletal and cardiac muscles can be affected by muscle wasting and until now an effective treatment is unknown. Only experimental trials of exercise training bring to a…
Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Train…
2022
Cachexia is a multifactorial and multi-organ syndrome that is a major cause of morbidity and mortality in late-stage chronic diseases. The main clinical features of cancer-related cachexia are chronic inflammation, wasting of skeletal muscle and adipose tissue, insulin resistance, anorexia, and impaired myogenesis. A multimodal treatment has been suggested to approach the multifactorial genesis of cachexia. In this context, physical exercise has been found to have a general effect on maintaining homeostasis in a healthy life, involving multiple organs and their metabolism. The purpose of this review is to present the evidence for the relationship between inflammatory cytokines, skeletal mus…
Cachexia: a therapeutic approach beyond cytokine antagonism
2002
Cachexia is seen in a number of chronic diseases, and it is always associated with a poor prognosis. Irrespective of etiology, the development of cachexia appears to share a common pathophysiological pathway. This includes induction of proteasome-dependent myofibril-degradation, which is thought to be secondary to stimulation by enhanced levels of pro-inflammatory cytokines. Elevation of tumor necrosis factor-alpha (TNFalpha) and other plasma cytokines has been demonstrated in many conditions associated with cachexia. Despite improved pathophysiological understanding, a specific treatment for cachexia has not yet been established. Whilst direct TNFalpha antagonism has therapeutic appeal, th…
Activin-A, myostatin and interleukin-6 in cancer associated cachexia
2017
Cachexia is a muscle wasting condition associated with multiple different chronic illnesses, such as cancer, diabetes and AIDS. In cancer, approximately 80% of patients with advanced disease have symptoms of muscle wasting, and around 25% of cancer mortality concerns cachexia. Elevated serum levels of different cytokines and TGF-β protein family members, such as Interleukin-6, Myostatin and Activin-A, have been observed in cachetic patients and test animals. However, the mechanistic role and the relative contribution of these molecules to muscle loss in the syndrome have not yet been fully elucidated. In this thesis, the gene-expression levels of Activin-A, Myostatin and Interleukin-6 was a…
Host-related factors and cancer: Malnutrition and non-Hodgkin lymphoma
2022
Assessment of host-related factors is a crucial aspect in the comprehensive management of cancer patients. A distinct nutritional disturbance linked to cancer has been recognized to be associated with negative outcomes. However, compared to solid tumors, only a limited number of studies have looked specifically at nutritional issues in the field of lymphoma. The aim of this review is to integrate the current knowledge on interactions between malnutrition and lymphoma and address most relevant and pertinent questions. We first provide a literature review on the mutual biological relationship between malnutrition and lymphoma. Next, we explore the overlap between malnutrition, sarcopenia, cac…
Ordinal mind change complexity of language identification
1997
The approach of ordinal mind change complexity, introduced by Freivalds and Smith, uses constructive ordinals to bound the number of mind changes made by a learning machine. This approach provides a measure of the extent to which a learning machine has to keep revising its estimate of the number of mind changes it will make before converging to a correct hypothesis for languages in the class being learned. Recently, this measure, which also suggests the difficulty of learning a class of languages, has been used to analyze the learnability of rich classes of languages. Jain and Sharma have shown that the ordinal mind change complexity for identification from positive data of languages formed…
Linguistic interpretation of speech errors
2016
The paper is an attempt to illustrate the linguistic interpretation of speech, known that it remains insufficiently resolved, especially for Romanian. The cause is given by the multitude of criteria that can or should be considered important in speech processing. The aim of this study is to develope a computational tool in order to identify the possible errors related to the morphosintactic structure of speech. Our goal is to assist users who can receive automatically different suggestions that can help them to improve the quality of their text. Thus, we chose an interdisciplinary approach through speech analysis that brings together the key fields of linguistics, computer science and so on…