Search results for "caffeine"

Nutritional prevention of cognitive decline and dementia.

2018

Cognitive impairment results from a complex interplay of many factors. The most important independent predictor of cognitive decline is age but other contributing factors include demographic, genetic, socio-economic, and environmental parameters, including nutrition. The number of persons with cognitive decline and dementia will increase in the next decades in parallel with aging of the world population. Effective pharmaceutical treatments for age-related cognitive decline are lacking, emphasizing the importance of prevention strategies. There is extensive evidence supporting a relationship between diet and cognitive functions. Thus, nutritional approaches to prevent or slow cognitive decli…

Use of nutritional supplement to improve performance in professional soccer players: A case report

2020

The aim of the study was to investigate the intake percentage and the satisfaction level of some nutritional supplements used by professional soccer players. Twenty-nine professional soccer players (age: 24.6 ± 5.2 years, body weight: 79.2 ± 4.9 kg, body height: 1.83 ± 0.05 m) belonging to a team of Serie A were interviewed on: frequency of use, tolerability, and acceptance of the supplements (creatine, β-alanine, whey protein, nitrates, vitamin D3, caffeine) proposed by the nutritionist team. This survey revealed a great inter-individual variability on the intake of the proposed supplements. All respondents (n = 29) said they take cholecalciferol (vitamin D3), 17 out of 29 creatine, 14 out…

Electrochemical C−H Functionalization of (Hetero)Arenes—Optimized by DoE

2020

Abstract A novel approach towards the activation of different arenes and purines including caffeine and theophylline is presented. The simple, safe and scalable electrochemical synthesis of 1,1,1,3,3,3‐hexafluoroisopropanol (HFIP) aryl ethers was conducted using an easy electrolysis setup with boron‐doped diamond (BDD) electrodes. Good yields up to 59 % were achieved. Triethylamine was used as a base as it forms a highly conductive media with HFIP, making additional supporting electrolytes superfluous. The synthesis was optimized using Design of Experiment (DoE) techniques giving a detailed insight to the significance of the reaction parameters. The mechanism was investigated by cyclic volt…

Reply to Dal Moro

2013

Vergleichende tierexperimentelle Untersuchungen mit Kaffee und Tee

1969

14C-Coffein wurde an Ratten als Coffeinlosung bzw. als Bestandteil eines Kaffee-oder Tee-Infuses per os verabreicht. Die Resorption von Coffein erfolgte nach Verabreichung von Coffeinlosung und Kaffee-Infus verhaltnismasg schnell, nach Verabreichung von Tee-Infus dagegen mit einer gewissen Verzogerung. Die14C-Aktivitatswerte im Serum und im Rattenkorper fielen nach Erreichung ihres Maximums nach Gabe von Coffein und Kaffee sehr schnell, nach Gabe von Tee dagegen sehr langsam ab. Die14C-Ausscheidung im Harn war nach Verabreichung von Tee deutlich geringer als nach Coffein oder Kaffee.

Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy

2007

In this randomized, double-blind, crossover clinical trial, adult patients treated two migraine attacks: one with almotriptan 12.5 mg and the other with ergotamine 2 mg plus caffeine 200 mg. Treatment with almotriptan was associated with a significantly greater proportion of patients achieving 2-h pain free (20.9% vs. 13.7%; P < 0.05) and 2-h pain relief (57.7% vs. 44.5%; P < 0.01) compared with ergotamine plus caffeine therapy; significant differences were not seen at 1 h. Rates for sustained pain free and sustained pain free plus no adverse events (AEs) also were significantly greater after almotriptan treatment than after the use of ergotamine plus caffeine (P < 0.05). Almotriptan was as…

Effects of Caffeine as an Adjuvant to Morphine in Advanced Cancer Patients

2001

Psychomotor abnormalities are one of the complications of opioid therapy in advanced cancer patients. Caffeine has potential properties to counteract the central effects of morphine. Twelve patients receiving stable doses of slow release morphine with adequate pain relief were scheduled for this double-blind placebo-controlled crossover trial. The treatment consisted of an intravenous dose of 1/6 of the daily morphine dose, using an intravenous/oral conversion ratio of 1:3. The dose calculated was administered in 5 minutes. Patients were randomly divided to received in a double-blind manner an infusion of 200 mg of caffeine or saline solution intravenously over one hour. A crossover took pl…

Use of Caffeine for Cognitive Enhancement

2015

Abstract Pharmacological cognitive enhancement (CE) refers to the use of divergent psychoactive substances with the purpose of enhancing one's own cognition (e.g., increasing vigilance, concentration, memory). The group of substances for CE includes divergent over-the-counter drugs. Caffeine-containing products such as coffee, caffeinated drinks, and caffeine tablets are integral part of this group of substances. Furthermore, prescription drugs as well as illicit drugs belong to this group of CE substances (e.g., [psycho-]stimulants, modafinil). The use of caffeine in normal healthy subjects has very limited procognitive effects. However, there are few procognitive effects in healthy but sl…

Perception des molécules chimiosensorielles en mélange : impact du métabolisme périphérique

2015

The chemosensory system is highly sensitive and discriminant. To ensure these properties, rapid and effective mechanisms are necessary to eliminate chemosensory molecules reaching the perception interface. The xenobiotic metabolizing enzymes (XMEs) present in the peri-receptor space may participate to the clearance of molecules thus limiting chemosensory receptors saturation and promoting the termination of the signal. In our PhD thesis, the involvement of these enzymes in the detection of stimuli in mixture was assessed in two animal models allowing to test complementary aspects. In Drosophila melanogaster, a sensory exposure to caffeine causes a reversible alteration of the taste percepti…

Caffeine analysis and extraction from a topical cream intended for UV-skin protection

2020

Made available in DSpace on 2021-06-25T10:16:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 This study aimed to develop and validate a method for the analysis of caffeine in complex cosmetic samples, such as sunscreens. Besides, an extraction method of caffeine from coffee oil and from creams, which contains both lipophilic and hydrophilic components, has been developed. The method to analyze caffeine was developed using an isocratic pump, Waters 1515 and an automatic injector Perkin-Elmer Series 200 and an UV detector Perkin-Elmer. As stationary phase, Kromasil C-18 (150 × 4.6 mm ID with particle size of 5 µm) column was used and a mixture of water (pH 4.00)/acetonitrile (…