Search results for "chronic"

Acetylcysteine therapy for chronic hepatitis C: are its effects synergistic with interferon alpha? A pilot study.

2008

This trial reports the 6-month results of a pilot study using lymphoblastoid interferon alpha (IFNalpha) and acetylcysteine (N-acetylcysteine) separately and in combination in patients with chronic hepatitis C, genotype 1b, who were nonresponders to previous treatment with recombinant IFNalpha alone.21 patients were randomly divided into three groups of seven each. Group A was treated with lymphoblastoid IFNalpha 6MU three times a week for 6 months; group B received the same schedule of lymphoblastoid IFNalpha as group A plus acetylcysteine 1200 mg/day per os in two administrations, and group C received only acetylcysteine 1200 mg/day per os in two administrations.Mean serum alanine aminotr…

Immunopositivity of heat shock protein 60 as a biomarker of bronchial carcinogenesis

2005

Cellul�re Immunreaktionen gegen�ber homologen leberspezifischen Antigenen (HLP) bei chronischen Leberentz�ndungen

1974

Es wird eine Zweiphasentechnik des Leukocyten-Migrations-Inhibitionstestes beschrieben und zum Nachweis einer cellularen Immunreaktion gegenuber Leberantigenen bei chronisch-entzundlichen Lebererkrankungen eingesetzt. Mit dieser Technik wurde bei 85% der Patienten mit hypergammaglobulinamischer Verlaufsform einer chronisch-aktiven Hepatitis und 42% der Patienten mit aktiv fortschreitenden kryptogenen Lebercirrhosen eine Migrationshemmung nachgewiesen. Lebergesunde Kontrollen zeigten keine, Patienten mit dem Zustand nach Hepatitis und chronisch-persistierender Hepatitis selten eine Leukocytenmigrationsinhibition gegenuber leberspezifischen Antigenen. 17% der Patienten mit chronisch-aktiver H…

EFFECT OF A β2 ADRENOCEPTOR AGONIST ON ACUTE AND CHRONIC GASTRIC ULCER IN THE RAT

1978

Spinal neuronal correlates of tapentadol analgesia in cancer pain: A back-translational approach

2014

Background Pain is a common and highly debilitating complication for cancer patients significantly compromising their quality of life. Cancer-induced bone pain involves a complex interplay of multiple mechanisms including both inflammatory and neuropathic processes and also some unique changes. Strong opioids are a mainstay of treatments but side effects are problematic and can compromise optimal pain control. Tapentadol is a novel dual-action drug, both stimulating inhibitory μ-opioid receptors (MOR) and mediating noradrenaline reuptake inhibition (NRI) leading to activation of the inhibitory α-2 adrenoceptor. It has been demonstrated to treat effectively both acute and chronic pain. We he…

Manejo perioperatorio del dolor en el paciente en tratamiento crónico con opiáceos

2011

Pain is one of the most common reasons for seeking medical care and the frequency of prescription of opioid analgesics by both primary care physicians and specialists has increased. It is therefore unsurprising that many patients with chronic pain who must undergo scheduled or emergency surgery will be on long-term medication, including opioids. Managing postoperative pain, even with high doses of drugs, seems to be more difficult in regular users of such analgesics, possibly because of an apparent association of opioid use with increased tolerance and hyperalgesia. Postoperative pain relief should be carefully tailored in these cases by means of a management plan worked out along with the …

Intravenous Use of Methadone: Efficacy and Safety

2013

Parenteral methadone could be helpful in specific conditions, particularly in unstable conditions of when the oral route is unavailable. Intravenous methadone should be the preferred parenteral route, due to concerns about the local toxicity of subcutaneous route. This chapter assesses aspects regarding the pharmacokinetic issues, the clinical use, the problems associated with the use of intravenous methadone for chronic pain, as well as the perioperative use of intravenous methadone.

Bipolar disorder: An evolutionary psychoneuroimmunological approach

2021

Abstract Bipolar disorder is a mental health disorder characterized by extreme shifts in mood, high suicide rate, sleep problems, and dysfunction of psychological traits like self-esteem (feeling inferior when depressed and superior when manic). Bipolar disorder is rare among populations that have not adopted contemporary Western lifestyles, which supports the hypothesis that bipolar disorder results from a mismatch between Homo sapiens’s evolutionary and current environments. Recent studies have connected bipolar disorder with low-grade inflammation, the malfunctioning of the internal clock, and the resulting sleep disturbances. Stress is often a triggering factor for mania and sleep probl…

Adaptive treatment of anemia on hemodialysis patients: A reinforcement learning approach

2011

The aim of this work is to study the applicability of reinforcement learning methods to design adaptive treatment strategies that optimize, in the long-term, the dosage of erythropoiesis-stimulating agents (ESAs) in the management of anemia in patients undergoing hemodialysis. Adaptive treatment strategies are recently emerging as a new paradigm for the treatment and long-term management of the chronic disease. Reinforcement Learning (RL) can be useful to extract such strategies from clinical data, taking into account delayed effects and without requiring any mathematical model. In this work, we focus on the so-called Fitted Q Iteration algorithm, a RL approach that deals with the data very…

Relationship between quality of life and anxiety aspects in chronic spontaneous urticaria

2019

Introduction: Clinical experience indicates the role of the psychological component in chronic spontaneous urticaria (CSU). The CSU can lead to psychological disturbances. This phenomenon results in a possible quality of life impairment among CSU patients. Aim: To analyse in detail the quality of life parameters and anxiety aspects in relation to CSU duration and symptom intensity. Material and methods: The patient sample was composed of 67 CSU subjects. For the quality of life and mental status assessment, all subjects were questionnaired with CU-Q2 oL and State and Trait Anxiety Inventory (STAI). In the control group, 42 healthy volunteers were enrolled to fill in the STAI questionnaire. …