Search results for "classes"
showing 10 items of 115 documents
Novel 3D bio-macromolecular bilinear descriptors for protein science: Predicting protein structural classes
2015
In the present study, we introduce novel 3D protein descriptors based on the bilinear algebraic form in the ℝn space on the coulombic matrix. For the calculation of these descriptors, macromolecular vectors belonging to ℝn space, whose components represent certain amino acid side-chain properties, were used as weighting schemes. Generalization approaches for the calculation of inter-amino acidic residue spatial distances based on Minkowski metrics are proposed. The simple- and double-stochastic schemes were defined as approaches to normalize the coulombic matrix. The local-fragment indices for both amino acid-types and amino acid-groups are presented in order to permit characterizing fragme…
Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3
2014
Evolution has produced proteins with exquisite ligand binding specificity, and manipulating this effect has been the basis for much of modern rational drug design. However, there are general classes of proteins with broader ligand selectivity linked to function, the origin of which is poorly understood. The odorant binding proteins (OBPs) sequester volatile molecules for transportation to the olfactory receptors. Rat OBP3, which we characterize by X-ray crystallography and NMR, binds a homologous series of aliphatic gamma-lactones within its aromatic-rich hydrophobic pocket with remarkably little variation in affinity but extensive enthalpy/entropy compensation effects. We show that the bin…
La constitution des classes dans les écoles. Contraintes de contexte ou stratégies d'acteurs ?: Rapport intermédiaire pour le PIREF
2005
05004; Analyse des pratiques de constitution des classes (nombre et nature des classes au sein des écoles), puis des modalités d'affectation des élèves et des enseignants dans ces classes et enfin de l'efficacité pédagogique des différents types de groupement réalisés.
Psychometric properties of the interaction on supervised classes scale (ISCS)
2016
Objeto: La presente investigación se centra en la construcción y validación de una escala diseñada para evaluar la calidad de la clases dirigidas: Escala de Interacción en las Clases Dirigidas (EICD). Diseño/metodología/enfoque: Se trata de un estudio descriptivo correlacional. Para la elaboración de la escala se recurrió a tres fases diferenciadas en las que diferentes expertos evaluaron la adecuación de los ítems, finalmente se estudiaron las propiedades psicométricas de la versión final en una muestra de 314 socios (69.1% mujeres) con edades entre los 18 y los 77 con una media de 39.33 años (DT=12.25). Aportaciones y resultados: La escala presenta una validez y fiabilidad adecuadas, sien…
Thermo-hygrometric comfort in the lecture hall of a library: methodology and experimental evidence.
2012
The present study verifies the thermo hygrometric comfort conditions in subjects of a university library users, evaluating the differences and peculiarities in the data collected at the measurement campaign. Particularities of the investigation is the period studied concerning the time frame of the Middle season, which is not expected to power the air conditioning systems. Based on assumptions on the thermal resistance of clothing in the spring and the metabolic type of subjects, the environmental parameters were monitored in some work position in the reading hall in the library of the Faculty of Medicine and Surgery of the University of Palermo. The article presents analyses of the measure…
Online Civic Identity. Extraction of Features
2013
Abstract The paper presents the importance of study the reactions of the readers and writers of online journals forums from the civic identity point of view, in order to put in evidence categories of publics in the benefit of media, persons and groups. The method is intended to help journalists, PR specialists who are motivated to understand their publics and to target them in a more precise way, in order to upgrade the impact of their online discourse on the people in the community, to know how deep the civic involvement of the people is to the problems of the community.
Conditions et enjeux pédagogiques de la constitution de classes à cours multiples dans les écoles primaires
2006
06022; La problématique de cette recherche s'inscrit dans le schéma global suivant, qui se donne pour objectif d'analyser successivement les pratiques de constitution des classes (nombre et nature des classes au sein des écoles), les modalités d'affectation des élèves et des enseignants dans ces classes et enfin l'efficacité pédagogique des différents types de groupement réalisés.
Bioassays to monitor taspase1 function for the identification of pharmacogenetic inhibitors
2011
Background Threonine Aspartase 1 (Taspase1) mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia provoking MLL-fusions. In contrast to other proteases, the understanding of Taspase1's (patho)biological relevance and function is limited, since neither small molecule inhibitors nor cell based functional assays for Taspase1 are currently available. Methodology/Findings Efficient cell-based assays to probe Taspase1 function in vivo are presented here. These are composed of glutathione S-transferase, autofluorescent protein variants, Taspase1 cleavage sites and rational combinations of nuclear import and export signals. The biosensors localize predominantly to the cytoplasm…
Chern classes of the moduli stack of curves
2005
Here we calculate the Chern classes of ${\bar {\mathcal M}}_{g,n}$, the moduli stack of stable n-pointed curves. In particular, we prove that such classes lie in the tautological ring.
CHARACTERIZATIONS OF STRICTLY SINGULAR AND STRICTLY COSINGULAR OPERATORS BY PERTURBATION CLASSES
2011
AbstractWe consider a class of operators that contains the strictly singular operators and it is contained in the perturbation class of the upper semi-Fredholm operators PΦ+. We show that this class is strictly contained in PΦ+, solving a question of Friedman. We obtain similar results for the strictly cosingular operators and the perturbation class of the lower semi-Fredholm operators PΦ−. We also characterize in terms of PΦ+ and in terms of PΦ−. As a consequence, we show that and are the biggest operator ideals contained in PΦ+ and PΦ−, respectively.