Search results for "classical conditioning"
showing 10 items of 52 documents
The endocannabinoid system in anxiety, fear memory and habituation.
2011
Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has been accumulated, providing leads for novel therapeutic approaches. In anxiety, a bidirectional influence of the ECS has been reported, whereby anxiolytic and anxiogenic responses have been obtained after both increases and decreases of the endocannabinoid tone. The recently developed genetic tools have revealed different but complementary roles for the cannabinoid type 1 (CB1) receptor on GABAergic and glutamatergic neuronal populations. This dual functionality, together with the plasticity of CB1 receptor expression, particularly on GABAergic neurons, as induced by stressful and rewarding experiences…
Interpositus nucleus inactivation reduces unconditioned response amplitude after paired but not explicitly unpaired treatment in rabbit eyeblink cond…
2001
The amplitude of unconditioned responses (URs) in unconditioned stimulus (US) alone presentations were measured in six rabbits during explicitly unpaired and classical conditioning treatments. After both phases of the experiment, the interpositus nucleus (IPN) was reversibly inactivated by a cold probe. URs after unpaired treatment were unaffected by inactivation but after acquisition of a robust level of conditioned responses (CRs), URs in US-alone test trials were reduced in amplitude compared with URs immediately before and after inactivation. The results suggest that the IPN has a role in CR-related reflex modification.
Cooling of the cerebellar interpositus nucleus abolishes somatosensory cortical learning-related activity in eyeblink conditioned rabbits.
2005
Nictitating membrane movement and multiple-unit activity in the somatosensory cortex were recorded from rabbits during paired (N = 6) and unpaired (N = 5) presentations of a tone conditioned stimulus (CS) and an airpuff unconditioned stimulus (US). A behavioural conditioned response (CR) to the CS and an accompanying neural response in the somatosensory cortex developed only in the paired group. Inactivation of the cerebellar interpositus nucleus abolished both the acquired CR and the accompanying neural response. However, the CS facilitated both behavioural and neural responses to the US during the inactivation. Thus, the absence of the CR could not be accounted for by the general inabilit…
Bilaterally recorded multiple-unit activity of the cingulate cortex during head turning conditioning with unilateral medial forebrain bundle stimulat…
1993
Cats were conditioned to turn their heads using a tone conditioned stimulus (CS) and medial forebrain bundle stimulation (MFB) unconditioned stimulus (US). The CS+ was delivered to one ear at a time, in random order, followed by the US. A tone of a different frequency was used as a CS-. The cats learned to respond differentially to the CSs showing head movements of greater acceleration to the CS+ than CS- over sessions. Bilateral recordings of cingulate cortex multiple-unit activity showed increased response amplitudes over sessions and larger responses in the hemisphere ipsilateral to the US. Since ipsilateral multiple-unit responses did not differ for the CSs, the asymmetry was probably d…
Asymmetries in classically conditioned head movements and cingulate cortex slow potentials in cats.
1991
Presuming that conditioned head movements in the cat indicate a preference for a specific direction, asymmetries were also expected to be found in bilaterally recorded cingulate cortex slow potentials to a symmetrical tone stimulus during discriminative conditioning. Conditioned stimuli (CS, 1000 and 2500 Hz tones) were delivered through two miniature loudspeakers fitted to the head in front of both ears. The unconditioned stimulus (US) was an electrical stimulation of either the left or right lateral hypothalamus yielding, in addition to its rewarding effects, an unconditioned head turning response (UR) either to the left, right, forwards or upwards. Discrimination learning appeared as mor…
Unilateral medial forebrain bundle activation selectively enhances conditioned orienting head turns and ipsilateral cingulate cortex evoked field res…
1994
Effects of a unilateral medial forebrain bundle (MFB) stimulation unconditioned stimulus (US) on conditioned head turn and bilateral cingulate cortex field potentials were studied in cats. Conditioned stimuli (CSs) of different frequences were given randomly to either ear. The CS+ was followed by the US, and the CS— was presented alone. Before conditioning most cats predominantly turned toward the ear to which the CSs were presented, whereas after conditioning the head turns were in one direction, most prominently contralateral to the US. Negative field potentials were greater in the cingulate cortex ipsilateral to the US than in the cingulate cortex contralateral to the US. Cross correlati…
Tonically Active Neurons in the Monkey Striatum are Sensitive to Sensory Events in a Manner that Reflects their Predictability in Time
2002
It is now well established that tonically active neurons (TANs) in the monkey striatum respond to motivationally relevant sensory events, such as conditioned stimuli to which the animal had to react correctly to obtain reward. Recent findings obtained in our laboratory suggested that stimulus prediction may influence the responsiveness of the TANs. In the present study we specifically investigated the effects of temporal aspects of prediction on the responses of single TANs recorded both in the caudate nucleus and putamen of two macaque monkeys. Three different behavioral situations were employed: (1) an instrumental task, in which a visual stimulus triggering a rewarded movement was preced…
Conditioned orienting (alpha) and delayed behavioral and evoked neural responses during classical conditioning
1989
A differentiation of short-latency (alpha) and long-latency (delayed) classically conditioned behavioral and evoked neural (hippocampal) responses was attempted. Further, facilitation and retardation of these responses were studied in an experimental design in which 10 paired conditioning sessions either preceded (CC-CO group) or followed (CO-CC group) 10 randomly unpaired presentations of conditioned stimuli (CS) and unconditioned stimuli (UCS). A 2024-ms tone (1000 Hz) was delivered directly through a miniature earphone to the left ear, eliciting an orienting head movement ('alpha' response) to the left. The unconditioned stimulus (UCS) was a direct 1024-ms stimulation of the lateral hypo…
Evidence of the origin of specific spontaneous head turns during intertrial intervals.
1997
Direction and the frequency of spontaneous head movements during the ITIs following forward and backward paired trials were compared to an acquisition of a conditioned orienting (alpha) response directed to the side of the tone source. The head movements were analyzed from video recordings using classification of head turns to preferred and to nonpreferred directions. The results showed a significant increase in the alpha responses during the forward paired conditioning to the preferred direction and rapid extinction during the subsequent backward conditioning sessions. Spontaneous head movements during the ITIs increased to the same preferred direction as the conditioned alpha responses. T…
Learning to be a psychostimulants addict with self-regulation therapy
2018
This article presents the results of a single-case experiment of alternative treatments in which a participant applied the Self-Regulation Therapy (SRT) to reproduce the effects of a stimulant drug, methylphenidate, and a sedative, alcohol. The SRT is a learning procedure based on classic conditioning and suggestion that reproduces the effect of drugs by remembering the effects they have. The participant reproduced the effects of both drugs during ten sessions held on 5 consecutive days. To record effects, adjective scales were used that measured Drug effect, High, Rush, Energy, Tension and the General Factor of Personality (GFP). The results indicated that the participant was capable of in…