Search results for "combinatorial"
showing 10 items of 1208 documents
ChemInform Abstract: 1,7-Octadiene-Assisted Tandem Multicomponent Cross-Enyne Metathesis (CEYM)-Diels-Alder Reactions: A Useful Alternative to Mori′s…
2013
The protocol relies on a relay metathesis process, in which 1,7-octadiene acts as an in situ source of ethylene.
Bioorthogonal red and far-red fluorogenic probes for wash-free live-cell and super-resolution microscopy
2020
AbstractSmall-molecule fluorophores enable the observation of biomolecules in their native context with fluorescence microscopy. Specific labelling via bioorthogonal tetrazine chemistry confers minimal label size and rapid labelling kinetics. At the same time, fluorogenic tetrazine-dye conjugates exhibit efficient quenching of dyes prior to target binding. However, live-cell compatible long-wavelength fluorophores with strong fluorogenicity have been difficult to realize. Here, we report close proximity tetrazine-dye conjugates with minimal distance between tetrazine and fluorophore. Two synthetic routes give access to a series of cell permeable and impermeable dyes including highly fluorog…
I(py)2BF4, a New Reagent in Organic Synthesis: General Method for the 1,2-Iodofunctionalization of Olefins
1985
Synthesis of Novel Triazolopyridylboronic Acids and Esters. Study of Potential Application to Suzuki-Type Reactions.
2004
This paper describes a general method for the synthesis of novel [1,2,3]triazolo[1,5-a]pyridylboronic acids and esters, and the first results on Suzuki cross-coupling reactions with these new compounds and [1,2,3]triazolo[5,1-a]isoquinolylboronic acid, reacting with a variety of aryl halides as a route to 7-aryltriazolopyridines and 5-aryltriazoloisoquinolines.
ChemInform Abstract: Glycosylation-Induced Asymmetric Synthesis of 1-Substituted Tetrahydroisoquinolines.
2008
ChemInform Abstract: Fluorescent Chemosensors Containing Polyamine Receptors
2000
Chemosensors have attracted interest in many different scientific fields, such as environmental chemistry, medicine, and the processing and storage of information. These molecular-scale devices have the advantage of working on the same spatial scale as the chemical structures that are responsible for macroscopic behaviour observed in the environment or those associated with health problems. Moreover, they allow the construction of molecular-scale devices for information storage. In this review, we describe a family of chemosensors based on a polyamine receptor and a fluorescent signalling unit. Polyamine receptors are water-soluble ambidentate receptors; they are able to coordinate either m…
Fluorinated Pyrazoles and Indazoles
2014
The synthesis of fluorine containing pyrazoles has been boosted in the past decades due to the interesting properties that confer these building blocks in pharmaceutical and agricultural active ingredients. There are two main methods for the synthesis of fluorine-containing organic compounds, namely, the direct replacement of an atom or functional group such as diazo, hydroxyl, halogen or hydrogen by fluorine, and the modification of fluorine-containing building blocks. In the case of fluorinated pyrazoles the latter approach is the most commonly applied. This chapter deals primarily with the pivotal procedures that allow the preparation of fluoro- and fluoroalkyl- pyrazoles. Their benzocon…
Polycondensed nitrogen heterocycles. Part 22. Pyrrolo[3,4-d]-1,2,3-triazines: A new ring system as potential antineoplastic agent
1989
Diazotization of the 3-aminopyrrole-4-carboxamides 6a,b under different conditions directly led to the new ring system pyrrolo[3,4-d]-1,2,3-triazine in excellent yields through an intramolecular coupling reaction. In all the cases it was impossible to isolate the intermediate 3-diazopyrroles.