Search results for "commentary"

May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells

2018

Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with…

Cortical Temperature Change: A Tool for Modulating Brain States?12

2016

Reduction in temperature depolarizes neurons by a partial closure of potassium channels but decreases the vesicle release probability within synapses. Compared with cooling, neuromodulators produce qualitatively similar effects on intrinsic neuronal properties and synapses in the cortex. We used this similarity of neuronal action in ketamine-xylazine-anesthetized mice and non-anesthetized mice to manipulate the thalamocortical activity. We recorded cortical electroencephalogram/local field potential (LFP) activity and intracellular activities from the somatosensory thalamus in control conditions, during cortical cooling and on rewarming. In the deeply anesthetized mice, moderate cortical co…

Anticoagulation in splanchnic and cerebral vein thrombosis: Still groping in the dark.

2020

Salsolinol and ethanol-derived excitation of dopamine mesolimbic neurons: new insights

2013

Evidence supporting the essential role of brain-derived ethanol metabolites in the excitation of dopamine (DA) midbrain neurons has multiplied in the last 10–15 years. The pioneer and influential behavioral studies by CM Aragon and colleagues (see Correa et al., 2012 for a complete review) and more recent data (Sanchez-Catalan et al., 2009; Marti-Prats et al., 2010, 2013) have repeatedly demonstrated the crucial role displayed by acetaldehyde (ACD) in the locomotor and other behavioral responses elicited by ethanol. Although these experiments mainly used an indirect measure (exploratory locomotion) as an index of the excitation of DA neurons in the ventral tegmental area (VTA), results stro…

Whatever next? Predictive brains, situated agents, and the future of cognitive science

2012

In the target article, Andy Clark addresses the question of how a probabilistic predictive coding model of the mind relates to our personal level mental lives. This question, he suggests, is “potentially the most important” (MS46). The question is important indeed, but Clark’s answer fails to capitalize on another possible advantage of this approach. Clark suggests that there is a disconnect between the way the world appears to us, on one hand, and the way that it is represented in the brain, on the other. He deals with this disconnect by limiting the scope of the theory, by pointing out that he is discussing a theory of how brains encode and process information, not a theory about how thin…

Commentary

2014

The ten grand challenges of synthetic life

2011

The construction of artificial life is one of the main scientific challenges of the Synthetic Biology era. Advances in DNA synthesis and a better understanding of regulatory processes make the goal of constructing the first artificial cell a realistic possibility. This would be both a fundamental scientific milestone and a starting point of a vast range of applications, from biofuel production to drug design. However, several major issues might hamper the objective of achieving an artificial cell. From the bottom-up to the selection-based strategies, this work encompasses the ten grand challenges synthetic biologists will have to be aware of in order to cope with the task of creating life i…

Do Individual Effects Reflect Quantitative or Qualitative Differences in Cognition?

2021

Rouder and Haaf (2020) posed the important question if there are some individuals whose behavior is not in accordance with well-established experimental effects and whether these individual differences are quantitative or qualitative in nature. In our commentary, we discuss the distinction between quantitative and qualitative individual differences and between individual and average causal effects and come to the conclusion that this is not a new question, but in fact one that has already been discussed by Gordon W. Allport (1937) and Donald B. Rubin (1974, 1978). Moreover, we critically examine their proposed rule of thumb to collect about 100 trials per experimental condition to reliably …

Newborn infants' auditory system is sensitive to Western music chord categories

2013

Neural encoding of abstract rules in the audition of newborn infants has been recently demonstrated in several studies using event-related potentials (ERPs). In the present study the neural encoding of Western music chords was investigated in newborn infants. Using ERPs, we examined whether the categorizations of major vs. minor and consonance vs. dissonance are present at the level of the change-related mismatch response (MMR). Using an oddball paradigm, root minor, dissonant and inverted major chords were presented in a context of consonant root major chords. The chords were transposed to several different frequency levels, so that the deviant chords did not include a physically deviant f…

Paleoclimate and bubonic plague: a forewarning of future risk?

2010

Background Human cases of plague (Yersinia pestis) infection originate, ultimately, in the bacterium's wildlife host populations. The epidemiological dynamics of the wildlife reservoir therefore determine the abundance, distribution and evolution of the pathogen, which in turn shape the frequency, distribution and virulence of human cases. Earlier studies have shown clear evidence of climatic forcing on contemporary plague abundance in rodents and humans. Results We find that high-resolution palaeoclimatic indices correlate with plague prevalence and population density in a major plague host species, the great gerbil (Rhombomys opimus), over 1949-1995. Climate-driven models trained on these…