Search results for "complex"
showing 10 items of 5889 documents
Immune response to the 23-valent polysaccharide pneumococcal vaccine after the 7-valent conjugate vaccine in allogeneic stem cell transplant recipien…
2009
The current recommendations for active immunization after stem cell transplant (SCT) include 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7) from 3 months after transplant, followed by a 23-valent polysaccharide pneumococcal vaccine (PPV23). However, until now, the immune response to PPV23 after PCV7 has not been assessed after SCT. In the EBMT IDWP01 trial, 101 patients received 1 dose of PPV23 at 12 or 18 months, both after 3 doses of PCV7. The efficacy of PPV23 was assessed 1 month later and at 24 months after transplant by the pneumococcal serotype 1 and 5 antibody levels. Serotype 1 and 5 are not included in PCV7. Although the geometric mean concentrations were significantly …
Safety, tolerability, and immunologic noninferiority of a 13-valent pneumococcal conjugate vaccine compared to a 7-valent pneumococcal conjugate vacc…
2010
13-valent pneumococcal conjugate vaccine (PCV13) was compared to PCV7 in infants administered 4 doses. For the 7 common serotypes, PCV13- and PCV7-elicited responses showed comparable percent responders achieving 0.35mug/mL IgG threshold (exception 6B, 77.5% versus 87.1%, respectively) and OPA titers of 1:8; IgGs were lower than PCV7 but functional responses were generally comparable. For the 6 additional serotypes, PCV13-elicited IgG and functional OPA responses were notably greater than PCV7. The toddler dose boosted immune responses. Vaccines were comparable with regard to safety. PCV13 should be as effective as PCV7 in preventing pneumococcal disease caused by the common serotypes and m…
A comparative analysis of the products of GROEL-1 gene fromChlamydia trachomatisserovar D and the HSP60 var1 transcript fromHomo sapienssuggests a po…
2009
Summary Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.
Interaction Mechanism of Humans in a Cyber-Physical Environment
2015
The research initiative “Industrie 4.0” (I4.0) of the high-tech strategy announced by the German government targets the deployment of a cyber-physical system (CPS) in production and logistics. Such CPS-based environments are characterized by an increasing number of heterogeneous intelligent autonomous and communicating artifacts tightly integrated with humans. Thus, the human’s role will become a composite factor (“man-in-the-mesh”) for this future CPS environment, playing more than just a simple role inside the control loop. This paper investigates the need of a robust communication between CPS and humans, which includes a clear semantic of the exchanged information. For this purpose, a me…
A New Multiblock PLS Based Method to Estimate Causal Models: Application to the Post-Consumption Behavior in Tourism
2009
This study presents a new algorithm for estimating causal models based on multiblock PLS method. This new algorithm is tested in a particular post-consumption behavior with the aim of validating a complex system of relations between antecedents of value, perceived value, satisfaction and loyalty. The results are compared with the classical LVPLS method: both methods support the proposed structural relations, but the explained variance is slightly higher with the new algorithm.
Economic Allocation in Life Cycle Assessment The State of the Art and Discussion of Examples
2012
Summary This article examines methods for analyzing allocation in life cycle assessment (LCA); it focuses on comparisons of economic allocation with other feasible alternatives. The International Organization for Standardization's (ISO) guideline 14044 indicates that economic allocation should only be used as a last resort, when other methods are not suitable. However, the LCA literature reports several examples of the use of economic allocation. This is due partly to its simplicity and partly to its ability to illustrate the properties of complex systems. Sometimes a price summarizes complex attributes of product or service quality that cannot be easily measured by physical criteria. On th…
Forbidden Factors and Fragment Assembly
2002
In this paper we approach the fragment assembly problem by using the notion of minimal forbidden factors introduced in previous paper. Denoting by M(w) the set of minimal forbidden factors of a word w, we first focus on the evaluation of the size of elements in M(w) and on designing of an algorithm to recover the word w from M(w). Actually we prove that for a word w randomly generated by a memoryless source with identical symbol probabilities, the maximal length m(w) of words in M(w) is logarithmic and that the reconstruction algorithm runs in linear time. These results have an interesting application to the fragment assembly problem, i.e. reconstruct a word w from a given set I of substrin…
The OptQuest Callable Library
2005
In this chapter we discuss the development and application of a library of functions that is the optimization engine for the OptQuest system. OptQuest is commercial software designed for optimizing complex systems, such as those formulated as simulation models. OptQuest has been integrated with several simulation packages with the goal of adding optimization capabilities. The optimization technology within OptQuest is based on the metaheuristic framework known as scatter search. In addition to describing the functionality of the OptQuest Callable Library (OCL) with an illustrative example, we apply it to a set of unconstrained nonlinear optimization problems.
The set of conjugacy class sizes of a finite group does not determine its solvability
2014
Abstract We find a pair of groups, one solvable and the other non-solvable, with the same set of conjugacy class sizes.
Reducing Local Alphabet Size in Recognizable Picture Languages
2021
A recognizable picture language is defined as the projection of a local picture language defined by a set of two-by-two tiles, i.e. by a strictly-locally-testable (SLT) language of order 2. The family of recognizable picture languages is also defined, using larger k by k tiles, \(k>2\), by the projection of the corresponding SLT language. A basic measure of the descriptive complexity of a picture language is given by the size of the SLT alphabet using two-by-two tiles, more precisely by the so-called alphabetic ratio of sizes: SLT-alphabet/picture-alphabet. We study how the alphabetic ratio changes moving from two to larger tile sizes, and we obtain the following result: any recognizable pi…