Search results for "components"

showing 10 items of 292 documents

Bioactive aristolactams from Piper umbellatum.

2007

Four alkaloids named piperumbellactams A-D (1-4) were isolated from branches of Piper umbellatum together with known N-hydroxyaristolam II (5), N-p-coumaroyl tyramine (6), 4-nerolidylcatechol (7), N-trans-feruloyltyramine, E-3-(3,4-dihydroxyphenyl)-N-2-[4-hydroxyphenylethyl]-2-propenamide, beta-amyrin, friedelin, apigenin 8-C-neohesperidoside, acacetin 6-C-beta-d-glucopyranoside, beta-sitosterol, its 3-O-beta-d-glucopyranoside and its 3-O-beta-d-[6'-dodecanoyl]-glucopyranoside. Glycosidase inhibition, antioxidant and antifungal activities of these compounds were evaluated. Compounds 1-3 showed moderate alpha-glucosidase enzyme inhibition with IC50 values 98.07+/-0.44, 43.80+/-0.56 and 29.64…

Antifungal AgentsLactamsStereochemistryDPPHFriedelinPlant ScienceHorticultureBiochemistryHeterocyclic Compounds 4 or More Ringschemistry.chemical_compoundAlkaloidsMolecular BiologyPiperAcacetinbiologyMolecular StructurePlant ExtractsAlkaloidGeneral MedicineFree Radical ScavengersTyraminePiperaceaePlant Components Aerialbiology.organism_classificationchemistryApigeninPiperPhytochemistry
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Antimicrobial and antiproliferative activity of Peucedanum nebrodense (Guss.) Strohl.

2003

Abstract Acetone extract of Peucedanum nebrodense (Guss.) Strohl., a rare endemic species from the Madonie mountains (Sicily), was tested in vitro for its antimicrobial activity against bacterial reference strains and antiproliferative activity against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and L1210 (murine leukemia) cell lines. The acetone extract showed antiproliferative IC 50 values in the range of 14–0.27 μg/ml.

Antineoplastic AgentsHL-60 CellsBiologyPlant RootsAcetoneMiceAnti-Infective Agentshemic and lymphatic diseasesDrug DiscoverymedicinePeucedanum nebrodenseCoumarins Antimicrobial Antiproliferative activityAnimalsHumansLeukemia L1210PharmacologyTraditional medicinePlant ExtractsBiological activityPlant Components AerialAntimicrobialmedicine.diseaseIn vitroLeukemiaCell cultureK562 CellsPeucedanum nebrodenseCell DivisionChronic myelogenous leukemiaK562 cellsApiaceaeJournal of ethnopharmacology
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Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation.

2004

Two flavonoids, gnaphaliin and tiliroside, isolated from Helichrysum italicum, were studied in vitro for their capacity to inhibit Cu(2+)-induced human low density lipoprotein (LDL) and diluted plasma oxidation. LDL oxidation was monitored by conjugated diene, thiobarbituric acid-reactive substances (TBARS) formation and electrophoretic mobility on agarose gel. Gnaphaliin and tiliroside increased the lag-phase for diene conjugate production in a dose-dependent manner. The reduction of TBARS production confirmed the antioxidant activity of gnaphaliin and tiliroside with 50% inhibitory concentration (IC(50)) values of 8.0+/-3.9 microM and 7.0+/-2.6 microM respectively. Furthermore, the flavon…

AntioxidantCopper Sulfatemedicine.medical_treatmentProbucolPharmacognosyThiobarbituric Acid Reactive SubstancesLipid peroxidationchemistry.chemical_compoundInhibitory Concentration 50Drug DiscoverymedicineTBARSHumansBenzopyransIC50PharmacologyFlavonoidsHelichrysumChromatographyPlant ExtractsGeneral MedicineCholesterol LDLPlant Components AerialFlavonesLipoproteins LDLBiochemistrychemistryLow-density lipoproteinAgaroseLipid Peroxidationmedicine.drugPhytotherapyFitoterapia
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UV-Induced Changes of Active Components and Antioxidant Activity in Postharvest Pigeon Pea [Cajanus cajan (L.) Millsp.] Leaves

2013

In this study, the effect of UV irradiation (UV-A, UV-B, and UV-C) on phytochemicals, total phenolics, and antioxidant activity of postharvest pigeon pea leaves was evaluated. The response of pigeon pea leaves to UV irradiation was phytochemical specific. UV-B and UV-C induced higher levels of phytochemicals, total phenolics, and antioxidant activity in pigeon pea leaves compared with UV-A. Furthermore, UV-B irradiation proved to possess a long-lasting effect on the levels of phenolics and antioxidant activity. After adapting for 48 h at 4 °C following 4 h UV-B irradiation, total phenolics and antioxidant activity were approximately 1.5-fold and 2.2-fold increased from 39.4 mg GAE/g DM and …

AntioxidantbiologyPlant ExtractsChemistrymedicine.medical_treatmentActive componentsfood and beveragesGeneral Chemistrybiology.organism_classificationAntioxidantsPlant LeavesCajanusCajanusPhenolsPhytochemicalBotanymedicinePostharvestFood scienceGeneral Agricultural and Biological SciencesJournal of Agricultural and Food Chemistry
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Prophylaxis of Non-communicable Diseases: Why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated p…

2019

The World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases. The increasing knowledge on chemopreventive properties of certain food ingredients, in particular, those of plant origin, opened the discussion on the possibility to use edible plants or their active components in the prevention of these chronic diseases. Health-pro…

Antioxidants; Bioactive phytochemicals; Cancer; Chemoprevention; Civilization diseases; Flavonoids; Food synergyantioxidantPhytochemicalsRespiratory Tract DiseasesActive componentsDiseaseChemopreventionWorld healthAntioxidants03 medical and health sciencesbioactive phytochemical0302 clinical medicineFunctional foodNeoplasmsVegetablesDrug DiscoveryHumansMedicinecivilization diseaseflavonoidNoncommunicable Diseases030304 developmental biologyCancer2. Zero hungerPharmacologyFlavonoids0303 health sciencesTraditional medicineFood synergyHuman organismbusiness.industryBioactive phytochemicalsDiet3. Good healthDiabetes Mellitus Type 2Cardiovascular DiseasesFruit030220 oncology & carcinogenesisFruits and vegetablesDietary SupplementsEdible plantsCivilization diseasesCritical assessmentbusiness
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Screening and authentication of herbal formulations based on microextraction-assisted voltammetry of microparticles

2015

A simple solid state electrochemical methodology for screening and authentication of herbal formulations is described. The proposed method is based on the recording of the voltammetric response, in contact with aqueous buffers, of microparticulate films of antioxidant compounds resulting from micro-extraction of dried herbal samples with ethanol or acetone. The obtained voltammetric responses led us to differentiate between diverse active components upon application of bivariate and multivariate chemometric techniques. Resolution of herbal preparations containing two or more components is possible when well-separated voltammetric signals are recorded. In favorable cases, such characteristic…

Aqueous solutionChromatographyResolution (mass spectrometry)ChemistryGeneral Chemical EngineeringAbsolute quantificationGeneral EngineeringActive componentsSolid-stateAnalytical Chemistrychemistry.chemical_compoundAcetoneHerbal preparationsVoltammetryAnal. Methods
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Differenziazione e quantificazione dei carbonati litogenici e pedogenici di Gypsisuoli forestali attraverso l'analisi isotopica

2004

Gli autori riferiscono sui tipi e sui modelli di genesi dei carbonati dei suoli, attraverso l’uso degli isotopi del 13C. Lo studio è stato condotto in un’area dell’interno collinare argilloso siciliano, su suoli che evolvono sui depositi evaporitici della Serie Gessoso-Solfifera. Sono stati scelti cinque pedon su litotipi calcarei e non. I pedon sono stati descritti in campo e campionati secondo la sequenza degli orizzonti genetici; sui campioni di suolo sono state eseguite le seguenti analisi: tessitura, reazione, conducibilità elettrica, gesso, carbonio organico ed inorganico. Inoltre, parallelamente sono state eseguite le analisi isotopiche del carbonio organico ed inorganico. I risultat…

Authors report on forms and soil carbonate formation models as detected by 13C isotopes. This study was carried out in a clayey hilly area of central Sicily where soils have developed on evaporitic deposits of “Gessoso-Solfifera” Formation. Four pedons were selected both on calcareous and no calcareous lithotypes. Pedons were described in field and sampled according to sequence of genetic horizons. Soil samples were analyzed to investigate the following properties: particle size distribution reaction electrical conductivity gypsum organic and inorganic carbon. Moreover isotopic analyses were performed on organic and inorganic carbon. Results allow us to describe the complex relationships between biotic and abiotic soil components. In addition models of calcic horizon formation and their implication in soil classification were defined.Settore AGR/13 - Chimica Agraria
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Application of PGPB Combined with Variable N Doses Affects Growth, Yield-Related Traits, N-Fertilizer Efficiency and Nutritional Status of Lettuce Gr…

2022

Nitrogen (N) fertilization is a crucial agricultural practice for boosting production traits in vegetables. However, N synthetic fertilizers—commonly adopted by farmers—have several counterproductive effects on the environment and on humans. The research was performed to assess the combined influence of plant growth promoting bacteria (PGPB) (Azospirillum brasilense DSM 1690, A. brasilense DSM 2298 and Pseudomonas sp. DSM 25356) and various N fertilization doses (0, 30, 60 or 120 kg ha−1) on growth, yield, quality and nitrogen indices of lettuce in protected cultivation. Plant height, root collar diameter, number of leaves and fresh weight were enhanced by A. brasilense DS…

Azospirillum brasilense strainNUE<i>Azospirillum brasilense</i> strains; <i>Pseudomonas</i> sp.; N fertilization rate; ‘Canasta’ lettuce; nutritional features; functional components; NUEN fertilization rateNutritional featurePseudomonas sp.Functional componentAgronomy and Crop Science'Canasta' lettuce‘Canasta’ lettucePseudomonas spAgronomy; Volume 12; Issue 2; Pages: 236
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Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results f…

2021

The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010–241909 (Project EU-GEI).

Bipolar DisorderTime FactorsIntelligenceGenome-wide association studyDETERMINANTSpsychosi0302 clinical medicineInterquartile rangeSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.IMPUTATIONpolygenic scorepsychosis0303 health sciencesConfoundingEuropePsychiatry and Mental healthgenome-wide association studieSchizophreniaMajor depressive disorderlipids (amino acids peptides and proteins)Case-Control Studieduration of untreated psychosisBrazilHumanAdultPsychosismedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesTime FactorAcademicSubjects/MED00810DISORDERS1ST EPISODEILLNESSPsychotic Disorderduration of untreated psychosi03 medical and health sciencesInternal medicinemedicineHumansBipolar disorderGENOME-WIDE ASSOCIATIONSettore MED/25 - PsichiatriaMETAANALYSIS030304 developmental biologyDepressive Disorder Majorbusiness.industryCOMPONENTSTREATMENT DELAYmedicine.diseaseTRANSTORNO BIPOLARschizophreniapolygenic scoresPsychotic DisordersCase-Control Studiesdupgenome-wide association studiesbusiness030217 neurology & neurosurgeryRegular ArticlesGenome-Wide Association Study
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Discovering hidden brain network responses to naturalistic stimuli via tensor component analysis of multi-subject fMRI data

2021

The study of brain network interactions during naturalistic stimuli facilitates a deeper understanding of human brain function. To estimate large-scale brain networks evoked with naturalistic stimuli, a tensor component analysis (TCA) based framework was used to characterize shared spatio-temporal patterns across subjects in a purely data-driven manner. In this framework, a third-order tensor is constructed from the timeseries extracted from all brain regions from a given parcellation, for all participants, with modes of the tensor corresponding to spatial distribution, time series and participants. TCA then reveals spatially and temporally shared components, i.e., evoked networks with the …

Brain MappingsignaalinkäsittelyCognitive NeuroscienceMotion PicturesfMRIBrainReproducibility of Resultshermoverkot (biologia)signaalianalyysiTensor components analysisMagnetic Resonance Imagingtoiminnallinen magneettikuvausNaturalistic stimuliNeurologyInter-subject correlationHumansaivotutkimusNeuroImage
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