Search results for "context"
showing 10 items of 6304 documents
HER2 Signaling and Breast Cancer Stem Cells: The Bridge behind HER2-Positive Breast Cancer Aggressiveness and Therapy Refractoriness
2021
Simple Summary Breast cancer (BC) is not a single disease, but a group of different tumors, and altered HER2 expression defines a particularly aggressive subtype. Although HER2 pharmacological inhibition has dramatically improved the prognosis of HER2-positive BC patients, there is still an urgent need for improved knowledge of HER2 biology and mechanisms underlying HER2-driven aggressiveness and drug susceptibility. Emerging data suggest that the clinical efficacy of molecularly targeted therapies is related to their ability to target breast cancer stem cells (BCSCs), a population that is not only self-sustaining and able to differentiate into distinct lineages, but also contributes to tum…
Role of biomarkers in monitoring antiblastic cardiotoxicity
2016
Early detection of anticancer drug-induced cardiotoxicity (CTX) has been evaluated by most international scientific cardiology and oncology societies. High expectations have been placed on the use of specific biomarkers. In recent years, conventional biomarkers and molecules of more recent interest have been tested and compared in the context of anticancer drug-related CTX. Encouraging results were obtained from studies on molecules of myocardial damage, such as troponin and markers of myocardial wall stress, including circulating natriuretic peptides, as well as from the assessment of the products of inflammation or circulating levels of free radicals. However, clear guidelines on their se…
A sensemaking approach to a discursive ethical skill in healthcare management: the case of an oncopaediatric service
2015
International audience; This study uses the case of an oncological paediatric service to discuss sensemaking and discourse ethics in the context of caregiving, building ethical competence to provide the best care possible to children. The patients and their families live in paediatric care, some for several years. At length, an intense relationship may develop between the medical staff and patients' family members, albeit at times a difficult relationship. Still, interviews conducted indicated that when caregivers provided the best care possible to these patients, even in this harsh environment, an ethics of sensitivity made a positive difference both for the patients and the medical staff.…
Two routes to actorhood: Lexicalized potency to act and identification of the actor role
2015
The inference of causality is a crucial cognitive ability and language processing is no exception: recent research suggests that, across different languages, the human language comprehension system attempts to identify the primary causer of the state of affairs described (the “actor”) quickly and unambiguously (Bornkessel-Schlesewsky and Schlesewsky, 2009). This identification can take place verb-independently based on certain prominence cues (e.g., case, word order, animacy). Here, we present two experiments demonstrating that actor potential is also encoded at the level of individual nouns (a king is a better actor than a beggar). Experiment 1 collected ratings for 180 German nouns on 12 …
The European sTANDEM project for certification in medical English: standards, acceptability and transgression(s)
2014
In the global world of international communication, employers or institutions that wish to determine the language skills of non-native speakers of English usually turn to generalist proficiency tests such as the TOEFL (Test of English as a Foreign Language) or the slightly more business-oriented TOEIC (Test of English for International Communication). These tests enable test takers to certify that they have reached a certain level in skills needed in everyday life and, sometimes, workplace situations, but they do not assess language skills for specific purposes.Aware of this vacuum, a consortium of European teachers/researchers and international experts in the domain of medical English unde…
Zum Spannungsverhältnis zwischen ästhetischen und linguistischen Qualitätskriterien literarischer Übersetzungen
2017
Today, literary translation occupies a special place in the translation theory, despite the fact that some researchers consider the dichotomous division within the discipline into literary and non-literary texts as resolved and unjustified. This article is an attempt to present a breakdown of selected aesthetic and linguistic criteria for the quality assessment of literary translations in order to consider, on this basis, the validity of the interdisciplinary approach to the criticism of translation of literary texts. The analysis is focused in particular on the translation quality parameters established by Sigrid Kupsch-Losereit. It is then followed by the reflection on the possibilities t…
What makes a (ro)bot smart? : examining the antecedents of perceived intelligence in the context of using physical robots, software robots, and chatb…
2022
In recent years, the acceptance and use of intelligent robots and other kinds of intelligent systems have begun to gain more and more attention also in information systems research. Here, many studies have found the perceived intelligence of robots to act as one critical antecedent for their acceptance and use, but few studies have focused on the antecedents of perceived intelligence itself. In this study, we aimed to address this gap in prior research by examining the effects of individual intelligence dimensions on the overall intelligence perception of robots in the work context. In addition, we also examined the potential differences in these effects as well as in the individual intelli…
Implementation of the inclusive CICO Plus intervention for pupils at risk of severe behaviour problems in SWPBS schools
2020
Check in–check out (CICO) is a widely used and studied behavioural intervention. Although CICO is an effective way to support pupils’ behaviour in a school context, not all pupils benefit from basic CICO. A single-case experimental study was designed to evaluate the effects of CICO Plus support (CICO Plus) for participants whose behaviour was determined to be non-responsive to basic CICO. CICO Plus was planned and implemented with four pupils identified by school CICO teams as needing additional behavioural support. Individual CICO Plus support was planned by multiprofessional teams working on each pupil’s case. The CICO Plus support was based on teaching social skills and behaviour at leas…
Students’ engagement in learning by indigenous knowledge-chemistry lesson
2022
This study was aimed at assessing students’ engagement in an integrated indigenous knowledge-chemistry lesson (IIK-CL) designed using the processes involved in cassava dough production. The paper focuses on the behavioural, emotional and cognitive engagement and their impact on students’ construction of knowledge of the factors affecting rate of chemical reactions. The study was conducted in Swedru senior high school in the Agona East municipality of the Central Region of Ghana. A purposively sampled intact class of 26 students aged between 14 and 18 years formed the study. The control group for this study encompassed also 26 students randomly sampled from the remaining chemistry classes in…
Building natural science learning through youth science camps
2018
This study focuses on a youth science camp for pupils in sixth to ninth grades that is organized annually by the University of Jyväskylä, Finland. The main idea of the science camp is to learn to do guided inquiry in nature. The study investigates the significance of science camp for encouraging young participants to learn science and how the camp supports their learning. The research method used was a survey. Altogether, 47 youth participated in the camp in 2012 and 2013. The results show that the participants wanted to learn more about science than secondary school could offer, and science camp had a positive impact on their interest in science. It was possible to introduce important conc…