Search results for "costi"
showing 10 items of 900 documents
IL BENE DELLA DIGNITÀ UMANA IN SOCCORSO DELLA LEGGE MERLIN? : SULLA SENTENZA 141/2019 DELLA CORTE COSTITUZIONALE IN MATERIA DI FAVOREGGIAMENTO E RECL…
2019
Con la sentenza 141/2019 la Corte costituzionale ha dichiarato non fondata la questione di legittimità costituzionale dei reati di “reclutamento” e di “favoreggiamento” della prostituzione, proposta dalla Corte d’Appello di Bari. A partire dalla vicenda oggetto di giudizio, e dopo una preliminare indagine sui modelli di regolamentazione normativa della prostituzione volontaria e sui dubbi di legittimità costituzionale espressi dalla ordinanza di remissione, ci si sofferma su taluni aspetti critici della decisione. Nella prospettiva dell’Autore, la scelta di prostituirsi ha una inscindibile doppia natura (sessuale ed economica) e dunque una plurima copertura costituzionale; discutibili sono …
Fauna Europaea: Coleoptera 2 (excl. series Elateriformia, Scarabaeiformia, Staphyliniformia and superfamily Curculionoidea)
2015
Fauna Europaea provides a public web-service with an index of scientific names (including synonyms) of all living European land and freshwater animals, their geographical distribution at country level (up to the Urals, excluding the Caucasus region), and some additional information. The Fauna Europaea project covers about 230,000 taxonomic names, including 130,000 accepted species and 14,000 accepted subspecies, which is much more than the originally projected number of 100,000 species. This represents a huge effort by more than 400 contributing specialists throughout Europe and is a unique (standard) reference suitable for many users in science, government, industry, nature conservation an…
NKG2D stimulation of CD8(+) T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
2017
NKG2D is an activating receptor that is expressed on most cytotoxic cells of the immune system, including NK cells, γδ and CD8+ T cells. It is still a matter of debate whether and how NKG2D mediates priming of CD8+ T cells in vivo, due to a lack of studies where NKG2D is eliminated exclusively in these cells. Here we studied the impact of NKG2D on effector CD8+ T-cell formation. NKG2D-deficiency that is restricted to murine CD8+ T cells did not impair antigen-specific T-cell expansion following mCMV and LCMV infection, but reduced their capacity to produce cytokines. Upon infection, conventional dendritic cells induce NKG2D ligands, which drive cytokine production on CD8+ T cells via the Da…
Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity
2021
BackgroundTumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53 isoforms in cellular senescence process of non-immune cells. However, their role in lymphocytes, in particular tumor-antigen (TA) specific T cells remain largely unexplored.MethodsHuman T cells from peripheral blood were retrovirally engineered to coexpress a TA-specific T cell receptor and the Δ133p53α-isoform, and characterized for their cellular phenotype, metabolic profile and effector functions.ResultsPhenotypic analysis of Δ133p53α-modified T cells revealed a marked …
Immunotherapy of colorectal cancer: New perspectives after a long path
2016
Although significant therapeutic improvement has been achieved in the last 10 years, the survival of metastatic colorectal cancer patients remains in a range of 28 to 30 months. Presently, systemic treatment includes combination chemotherapy with oxaliplatin and/or irinotecan together with a backbone of 5-fluorouracil/levofolinate, alone or in combination with monoclonal antibodies to VEGFA (bevacizumab) or EGF receptor (cetuximab and panitumumab). The recent rise of immune checkpoint inhibitors in the therapeutic scenario has renewed scientific interest in the investigation of immunotherapy in metastatic colorectal cancer patients. According to our experience and view, here, we review the…
Le déploiement d'un pilotage stratégique des coûts dans les services informatiques de deux groupes internationaux : perspective instrumentale et anal…
2011
This article analyses the strategic cost management stream with an instrumental point of view and two case studies. We try to show in what extend the Activity-based Costing developments could be included in a strategic approach of the management accounting and to test if the ABC is a relevant tool to drive the strategy. The first part synthesizes the strategic cost management developments which try to improve the Activity-based Costing method. In the first part, we describe them using the Strategic Management Accounting stream, with a link with cost management and ABC. The second part exposes a taxonomy of the reasons why using the ABC method. In a third part, we confront our developments t…
“The Regular temporary occlusion in karst acquifers following earthquakes. The case of the Ciane-Aretusa springs-Sicily"
2005
“Submarine spring and salt water intrusion in fractured environment
2003
AUTODETERMINAZIONE SESSUALE NEL DIRITTO INTERNAZIONALE
2014
Legittima la scelta di abrogare parzialmente l'abuso di ufficio mediante decreto-legge
2021
La Corte costituzionale ha dichiarato non fondata la questione di legittimità dell’articolo 23, comma 1, del decreto-legge 16 luglio 2020, n. 76 (convertito nella legge 11 settembre 2020, n. 120) sollevata dal Gup del Tribunale di Catanzaro in riferimento all’articolo 77 della Costituzione, ritenendo legittima l’introduzione dell’art. 323 c.p. mediante decretazione d’urgenza. La Corte ha invece dichiarato inammissibile la questione relativa ai contenuti sostanziali della modifica, che secondo il Gup di Catanzaro avrebbe depotenziato eccessivamente la tutela del buon andamento e dell’imparzialità della pubblica amministrazione e violato il principio di uguaglianza (articoli 97 e 3 della Cost…