Search results for "cumulative"
showing 10 items of 299 documents
Analysis of relapse after transplantation in acute leukemia: A comparative on second allogeneic hematopoietic cell transplantation and donor lymphocy…
2018
Relapse of acute leukemia (AL) after allogeneic hematopoietic cell transplantation (Allo-HCT) entails a dismal prognosis. In this scenario, donor lymphocyte infusions (DLIs) and second Allo-HCT are two major approaches. We compared outcomes of AL patients treated for relapse with DLI or second Allo-HCT after receiving debulking therapy. In total, 46 patients were included in the study; 30 (65%) had acute myeloid leukemia and 16 (35%) had acute lymphoblastic leukemia. The median age was 38 years (range 4-66). Twenty-seven patients received a second Allo-HCT and 19 patients received DLI. The median follow-up of the cohort was 273 days (range 9-7013). Overall survival (OS), disease-free surviv…
The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.
2020
Bursts of beta frequency band activity in the basal ganglia of patients with Parkinson's disease (PD) are associated with impaired motor performance. Here we test in human adults whether small variations in the timing of movement relative to beta bursts have a critical effect on movement velocity and whether the cumulative effects of multiple beta bursts, both locally and across networks, matter.
Stochastic modeling and prediction of catalytic converters degradation
2009
This paper proposes a stochastic model for describing the degradation process of catalytic converters over time, where the degradation is indirectly measured through the emission of complex hydrocarbons (HC) in legislated driving cycles. The proposed model is the superposition of two processes, the former being a dependent increments process which describes the actual degradation process, and the latter a white noise process which models the experimental errors. In particular, the proposed model assumes that the degradation growth in a small usage interval depends on the degradation level at the beginning of the interval, rather than on the age of the converter. The model has been applied t…
Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the…
2004
Aims Patients with diabetes are at excessive risk of mortality and cardiovascular morbidity. Previous studies suggest that aspirin may be less effective in diabetic patients. In this multi-centre, randomized, double blind trial picotamide, a dual inhibitor of thromboxane A2 synthase and receptor, was compared with aspirin for the prevention of mortality and major cardiovascular events in diabetics with peripheral arterial disease (PAD). Methods and results A total of 1209 adults aged 40–75 years with type 2 diabetes and PAD were randomized to receive picotamide (600 mg bid) or aspirin (320 mg od) for 24 months. The cumulative incidence of the 2 years overall mortality was significantly lowe…
Comorbidity does not mean clinical complexity: evidence from the RePoSI register
2019
In the last 2–3 decades internists have confronted dramatic changes in the pattern of patients acutely admitted to hospital wards. Internists observed a shift from younger subjects affected by a single organ disease to more complex patients, usually older, with multiple chronic conditions, attended by different specialists, with poor integration and treated with multiple drugs. In this regard, the concept of complex patients is addressed daily in clinical practice even if there is no agreed definition of patient complexity. To try to evaluate clinical complexity different instruments have been proposed. Among these, the number of comorbidities (NoC) was considered a marker of clinical compl…
Participatory Ergonomics: A Model for the Prevention of Occupational Musculoskeletal Disorders
2009
La ergonomía participativa es una estrategia de intervención sobre los riesgos por carga física en los lugares de trabajo escasamente conocida en España, aunque en otros países se cuenta con numerosas experiencias y evidencias en este campo. Son varias las razones que justifican su interés. En primer lugar, aborda una de las categorías de riesgos laborales que mayor impacto tiene sobre la salud de los trabajadores en la mayoría de países, tanto en términos de incidencia, como de prevalencia o incapacidad. En segundo lugar, el principio básico de la ergonomía participativa es la capacitación de los trabajadores para que participen tanto en la identificación de los riesgos y daños a la salud …
Predictability of early atopy by cord blood-IgE and parental history.
1997
Summary Background Atopic family history and cord blood IgE have been used as predictors of atopic disease in newborns for about 20 years, but at least for cord blood IgE the sensitivity has been shown to be very low. The objective of this paper was to evaluate whether parental history and cord blood-IgE were more accurate predictors for the appropriate atopic phenotypes in the infants rather than for any atopy. Methods A total of 1314 newborn infants was recruited in six German obstetric departments in 1990 and followed-up for 2 years. Four hundred and ninty-ninc (38%) were at high risk for atopy with at least two first degree atopic family members and/or elevated cord-blood IgE concentrat…
Parental occupational exposure to endocrine disrupting chemicals and male genital malformations: a study in the Danish National Birth Cohort study
2011
Abstract Background Sex hormones closely regulate development of the male genital organs during fetal life. The hypothesis that xenobiotics may disrupt endogenous hormonal signalling has received considerable scientific attention, but human evidence is scarce. Objectives We analyse occurrence of hypospadias and cryptorchidism according to maternal and paternal occupational exposure to possible endocrine disrupting chemicals. Methods We conducted a follow-up study of 45,341 male singleton deliveries in the Danish National Birth Cohort during 1997-2009. Information on work during pregnancy was obtained by telephone interviews around gestational week 16. Parents' job titles were classified acc…
Pressure ulcers’ incidence, preventive measures, and risk factors in neonatal intensive care and intermediate care units
2018
Epidemiological studies on pressure ulcers (PUs) in hospitalised infants are scarce. Spain lacks comprehensive research studies providing data on the prevalence or incidence in this population. This work was developed to determine the incidence of PUs in hospitalised infants admitted to intensive and intermediate care units, along with relevant risk factors and preventive measures. A prospective study appraising the incidence of PUs in infants was performed. The risk factors and preventive measures were evaluated using a multivariate logistic regression model. A sample of 268 infants was included. The cumulative incidence of PUs was 12.70% (95% confidence interval, CI(95%) = [8.95%‐17.28%])…
The Infinite-Valued Łukasiewicz Logic and Probability
2017
The paper concerns the algebraic structure of the set of cumulative distribution functions as well as the relationship between the resulting algebra and the infinite-valued Łukasiewicz algebra. The paper also discusses interrelations holding between the logical systems determined by the above algebras. Zadanie „ Wdrożenie platformy Open Journal System dla czasopisma „ Bulletin of the Section of Logic” finansowane w ramach umowy 948/P-DUN/2016 ze środków Ministra Nauki i Szkolnictwa Wyższego przeznaczonych na działalność upowszechniającą naukę.