Search results for "curs"

Nonlinear Distribution Regression for Remote Sensing Applications

2020

In many remote sensing applications, one wants to estimate variables or parameters of interest from observations. When the target variable is available at a resolution that matches the remote sensing observations, standard algorithms, such as neural networks, random forests, or the Gaussian processes, are readily available to relate the two. However, we often encounter situations where the target variable is only available at the group level, i.e., collectively associated with a number of remotely sensed observations. This problem setting is known in statistics and machine learning as multiple instance learning (MIL) or distribution regression (DR). This article introduces a nonlinear (kern…

Random Feature Approximation for Online Nonlinear Graph Topology Identification

2021

Online topology estimation of graph-connected time series is challenging, especially since the causal dependencies in many real-world networks are nonlinear. In this paper, we propose a kernel-based algorithm for graph topology estimation. The algorithm uses a Fourier-based Random feature approximation to tackle the curse of dimensionality associated with the kernel representations. Exploiting the fact that the real-world networks often exhibit sparse topologies, we propose a group lasso based optimization framework, which is solve using an iterative composite objective mirror descent method, yielding an online algorithm with fixed computational complexity per iteration. The experiments con…

Properties of modified hepatitis B virus surface antigen particles carrying preS epitopes

1995

The current hepatitis B virus (HBV) vaccines contain the small (S) and middle (M) viral envelope proteins in particulate form but lack the large (L) protein. Although these particles elicit protective immunity to HBV, inclusion of the immunogenic preS1 region of the L protein may enhance their efficacy. To present preS1-derived epitopes on secretable subviral particles we rearranged the HBV envelope ORF by fusing part or all of the preS1 region to either the N or C terminus of the S protein. Fusion of the first 42 residues of preS1 to either site allowed efficient secretion of the modified particles and rendered the linked sequence accessible at the surface of the particle. Conversely, fusi…

Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus

2007

Abstract The tissue-invasive nematode Onchocerca volvulus causes skin and eye pathology in human onchocerciasis. While the adult females reside sessile in subcutaneous nodules, the microfilariae are abundantly released from the nodules, males and juvenile worms migrate through the host tissue. Matrix-degrading metallo- and serine proteinases have been detected in excretory-secretory worm products that may be essential for migration of the mobile stages. In this study, a 1713 bp long cDNA encoding for a putative proteinase of O. volvulus has been isolated. The predicted protein sequence includes a signal peptide indicating secretion to the extracellular space, a propeptide, an astacin-like p…

La conservación de los recursos vivos marinos antárticos en la Convención de Canberra de 1980

1989

l. INTRODUCCIÓN.- II. LA CONSERVACIÓN DE LOS RECURSOS MARINOS VIVOS EN LA ANTÁRTIDA.- III. VENTAJAS DE ESTE PLANTEAMIENTO CONSERVACIONISTA.- IV. INCONVENIENTES A LOS CONSERVACIÓN DE LOS RECURSOS VIVOS MARINOS ANTÁRTICOS: 1. Los recursos marinos vivos protegidos; 2. Soberanía y jurisdicción en la Antártida; 3. Necesidad de información científica; 4. Procedimiento de adopción de las medidas de conservación; 5. Las medidas de conservación; 6. El control de la aplicación de estas medidas; 7. El relativismo de los tratados; 8. Daños al medio ambiente antártico por otras actividades.- V. CONCLUSIONES.

Oratio habita apud Sixtum IV, exhortatoria contra Turcos / [Bernardus Justinianus

1481

Sense sign. - Data insegura, déu ésser entre 1481 i 1487 L. gòt. - 33 lín. - Esp. p. inic. - Sense fol.

Oratio habita apud Sixtum IV, exhortatoria contra Turcos

Sense sign. - Data insegura, déu ésser entre 1481 i 1487 L. gòt. - 33 lín. - Esp. p. inic. - Sense fol

Small RNA‐binding protein RapZ mediates cell envelope precursor sensing and signaling in Escherichia coli

2019

Abstract The RNA‐binding protein RapZ cooperates with small RNAs (sRNAs) GlmY and GlmZ to regulate the glmS mRNA in Escherichia coli. Enzyme GlmS synthesizes glucosamine‐6‐phosphate (GlcN6P), initiating cell envelope biosynthesis. GlmZ activates glmS expression by base‐pairing. When GlcN6P is ample, GlmZ is bound by RapZ and degraded through ribonuclease recruitment. Upon GlcN6P depletion, the decoy sRNA GlmY accumulates through a previously unknown mechanism and sequesters RapZ, suppressing GlmZ decay. This circuit ensures GlcN6P homeostasis and thereby envelope integrity. In this work, we identify RapZ as GlcN6P receptor. GlcN6P‐free RapZ stimulates phosphorylation of the two‐component sy…

Reseña del libro "América Latina hacia su unidad. Modelos de integración y procesos integradores"

2008

Des expatriés de retour frustrés mais fidèles à leur organisation. Analyse d’un paradoxe à l’aide de la théorie du don/contre-don

2021

Cet article analyse le comportement paradoxal des expatriés de retour frustrés mais fidèles à leur organisation à partir d’une théorie encore émergente en sciences de gestion, celle du don/contre-don de Marcel Mauss. En considérant une expérience d’expatriation comme un « fait social total » qui inclut le passé, le présent et le futur de l’individu et articule l’ensemble des dimensions personnelles et professionnelles, nous proposons une perspective renouvelée sur la période du retour d’expatriation et formulons des préconisations managériales qui prennent en compte les mécanismes nouveaux mis en évidence.