Search results for "cycle"
showing 10 items of 3119 documents
LIFE CYCLE ASSESSMENT OF ITALIAN CITRUS BASED PRODUCTS. SENSITIVITY ANALYSIS AND IMPROVMENT SCENARIOS
2010
Though many studies concern the agro-food sector in the EU and Italy, and its environmental impacts, literature is quite lacking in works regarding LCA application on citrus products. This paper represents one of the first studies on the environmental impacts of citrus products in order to suggest feasible strategies and actions to improve their environmental performance. In particular, it is part of a research aimed to estimate environmental burdens associated with the production of the following citrus-based products: essential oil, natural juice and concentrated juice from oranges and lemons. The life cycle assessment of these products, published in a previous paper, had highlighted sign…
What distance do university students walk and bike daily to class in Spain
2016
Abstract Introduction Physical activity levels are low in the general population and these levels decrease from childhood to adolescence, as well as from adolescence to adulthood. Active commuting (AC) is an opportunity to increase the physical activity levels. The distance between home and destinations is a main correlate of AC; however, the distance that university students walk or cycle to university is unknown. Methods Participants self-reported their modes and time of commuting to and from university in a questionnaire, and the main mode of commuting was identified. Moreover, they reported their home address, and the Spanish version of Mapquest software was used to measure street-netwo…
Local minimizers and gamma-convergence for nonlocal perimeters in Carnot groups
2020
We prove the local minimality of halfspaces in Carnot groups for a class of nonlocal functionals usually addressed as nonlocal perimeters. Moreover, in a class of Carnot groups in which the De Giorgi's rectifiability Theorem holds, we provide a lower bound for the $\Gamma$-liminf of the rescaled energy in terms of the horizontal perimeter.
Heteroclinic contours and self-replicated solitary waves in a reaction–diffusion lattice with complex threshold excitation
2008
Abstract The space–time dynamics of the network system modeling collective behavior of electrically coupled nonlinear cells is investigated. The dynamics of a local cell is described by the FitzHugh–Nagumo system with complex threshold excitation. Heteroclinic orbits defining traveling wave front solutions are investigated in a moving frame system. A heteroclinic contour formed by separatrix manifolds of two saddle-foci is found in the phase space. The existence of such structure indicates the appearance of complex wave patterns in the network. Such solutions have been confirmed and analyzed numerically. Complex homoclinic orbits found in the neighborhood of the heteroclinic contour define …
Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells
2013
Abstract Ethnopharmacological relevance Beilschmiedia acuta Kosterm, Clausena anisata (Willd) Hook, Fagara tessmannii Engl., Newbouldia laevis Seem., and Polyscias fulva (Hiern) Harms. are medicinal plants used in Cameroonian traditional medicine in the treatment of various types of cancers. The present study aims at investigating 11 methanolic extracts from the above Cameroonian medicinal plants on a panel of human cancer cell lines, including various drug-resistant phenotypes. Possible modes of action were analyzed for two extracts from Beilschmiedia acuta and Polyscia fulva and alpha-hederin, the representative constituent of Polyscia fulva. Materials and methods Cytotoxicity was determi…
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives.
2014
STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin's lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.
MAP kinase p38 and its relation to T cell anergy and suppressor function of regulatory T cells
2008
Diverse regulatory T cell populations (Treg) are important for the control of self tolerance and immune homeostasis. These include naturally occurring CD4+CD25+ Treg (nTreg) and induced Treg (iTreg). Tolerogenic dendritic cells, modulated by IL-10, are able to convert peripheral T cells into iTreg. These are anergic and characterized by a G(1) cell cycle arrest, dependent on elevated levels of the cdk inhibitor p27(Kip1). Novel data revealed a distinct pattern of MAP kinase activation in iTreg different from clonal T cell anergy, with enhanced activation of the p38-MAPKAP-K2/3 pathway. p38 is involved in cell cycle control and its activity is a prerequisite for the induction and maintenance…
Identification of Tumor-Associated Autoantigens With SEREX
2004
Serological analysis of tumor antigens by recombinant cDNA expression cloning (SEREX) allows the systematic cloning of tumor antigens recognized by the spontaneous autoantibody repertoire of cancer patients. For SEREX, cDNA expression libraries are constructed from fresh tumor specimens, packaged into lambda-phage vectors, and expressed recombinantly in Escherichia coli. Recombinant proteins expressed during the lytic infection of bacteria are transferred onto nitrocellulose membranes to be probed with diluted autologous patient serum for identification of clones reactive with high-titered IgG antibodies. This chapter describes the SEREX technology in detail.
Reverse electrodialysis heat engine for sustainable power production
2017
Abstract Reverse Electrodialysis Heat Engine (REDHE) is a promising technology to convert waste heat at temperatures lower than 100 °C into electric power. In the present work an overview of the possible regeneration methods is presented and the technological challenges for the development of the RED Heat Engine (REDHE) are identified. The potential of this power production cycle was investigated through a simplified mathematical model. In the first part of the work, several salts were singularly modelled as possible solutes in aqueous solutions feeding the RED unit and the corresponding optimal conditions were recognized via an optimization study. In the second part, three different RED He…
Linear relationship between effective radius and precipitation water content near the top of convective clouds
2021
Quantifying the precipitation within clouds is a crucial challenge to improve our current understanding of the Earth’s hydrological cycle. We have investigated the relationship between the effective radius of droplets and ice particles (re) and precipitation water content (PWC) measured by cloud probes near the top of growing convective cumuli. The data for this study were collected by aircraft measurements in clean and polluted conditions over the Amazon Basin and over the western tropical Atlantic in September 2014. Our results indicate a threshold of re ∼ 13 μm for warm rain initiation in convective clouds, which is in agreement with previous studies. In…