Search results for "cyclic"
showing 10 items of 2439 documents
Cyclic coordinate for penalized Gaussian graphical models with symmetry restriction
2014
In this paper we propose two efficient cyclic coordinate algorithms to estimate structured concentration matrix in penalized Gaussian graphical models. Symmetry restrictions on the concentration matrix are particularly useful to reduce the number of parameters to be estimated and to create specific structured graphs. The penalized Gaussian graphical models are suitable for high-dimensional data.
Robust Conditional Independence maps of single-voxel Magnetic Resonance Spectra to elucidate associations between brain tumours and metabolites.
2020
The aim of the paper is two-fold. First, we show that structure finding with the PC algorithm can be inherently unstable and requires further operational constraints in order to consistently obtain models that are faithful to the data. We propose a methodology to stabilise the structure finding process, minimising both false positive and false negative error rates. This is demonstrated with synthetic data. Second, to apply the proposed structure finding methodology to a data set comprising single-voxel Magnetic Resonance Spectra of normal brain and three classes of brain tumours, to elucidate the associations between brain tumour types and a range of observed metabolites that are known to b…
The Co‐mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion‐Driven Cholangiocarcinoma
2021
Background and aims Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and a highly lethal malignancy. Chemotherapeutic options are limited, but a considerable subset of patients harbors genetic lesions for which targeted agents exist. Fibroblast growth factor receptor 2 (FGFR2) fusions belong to the most frequent and therapeutically relevant alterations in ICC, and the first FGFR inhibitor was recently approved for the treatment of patients with progressed, fusion-positive ICC. Response rates of up to 35% indicate that FGFR-targeted therapies are beneficial in many but not all patients. Thus far, no established biomarkers exist that predict resistance or r…
Design of RC joints equipped with hybrid trussed beams and friction dampers
2021
Abstract The challenge of this research consists in the first attempt to apply a dissipative friction connection to beam-to-column joints with semi-prefabricated Hybrid Steel-Trussed Concrete Beams (HSTCB) and RC pillars cast in-situ. Nowadays, HSTCBs are widely adopted in civil and industrial buildings and, therefore, it is required to evaluate their compliance with the capacity design criteria and their seismic energy dissipation capability. However, the design of the reinforcement of such beams usually lead to the adoption of large amount of steel within the panel zone which becomes potentially vulnerable to the effects of seismic cyclic actions and dramatically reduce the dissipation ca…
On minimal non-PC-groups
2009
On dit qu'un groupe G est un PC-groupe, si pour tout x ∈ G, G/C G (x G ) est une extension d'un groupe polycyclique par un groupe fini. Un non-PC-groupe minimal est un groupe qui n'est pas un PC-groupe mais dont tous les sous-groupes propres sont des PC-groupes. Notre principal resultat est qu'un non-PC-groupe minimal ayant un groupe quotient fini non-trivial est une extension cyclique finie d'un groupe abelien divisible de rang fini.
Gradings on the algebra of upper triangular matrices and their graded identities
2004
Abstract Let K be an infinite field and let UT n ( K ) denote the algebra of n × n upper triangular matrices over K . We describe all elementary gradings on this algebra. Further we describe the generators of the ideals of graded polynomial identities of UT n ( K ) and we produce linear bases of the corresponding relatively free graded algebras. We prove that one can distinguish the elementary gradings by their graded identities. We describe bases of the graded polynomial identities in several “typical” cases. Although in these cases we consider elementary gradings by cyclic groups, the same methods serve for elementary gradings by any finite group.
Mn(II) complexes of scorpiand-like ligands. A model for the MnSOD active centre with high in vitro and in vivo activity
2015
Manganese complexes of polyamines consisting of an aza-pyridinophane macrocyclic core functionalised with side chains containing quinoline or pyridine units have been characterised by a variety of solution techniques and single crystal x-ray diffraction. Some of these compounds have proved to display interesting antioxidant capabilities in vitro and in vivo in prokaryotic (bacteria) and eukaryotic (yeast and fish embryo) organisms. In particular, the Mn complex of the ligand containing a 4-quinoline group in its side arm which, as it happens in the MnSOD enzymes, has a water molecule coordinated to the metal ion that shows the lowest toxicity and highest functional efficiency both in vitro …
Sensitive determination of polycyclic aromatic hydrocarbons in water samples using monolithic capillary solid-phase extraction and on-line thermal de…
2011
A methacrylate-based monolithic capillary column has been evaluated for the preconcentration of polycyclic aromatic hydrocarbons (PAHs) from environmental water samples. For this purpose, the monolyte was in situ synthesized in a 6cm×0.32mm id fused-silica capillary. The microextraction unit was fitted to a micro-HPLC pump to pass 10mL of sample. The isolated pollutants were eluted by means of 10μL of methanol, the organic phase being directly collected in a specific interface that can be fitted to the injection port of the gas chromatograph without modification. The interface allows the on-line thermal desorption of the PAHs, avoiding the dilution and providing enough sensitivity to reach …
18F-labeling of peptides by means of an organosilicon-based fluoride acceptor.
2006
Fluorine-18 is among the most commonly used radionuclides for positron emission tomography (PET). This non-invasive imaging technique is capable of providing in vivo information about the distribution of radiolabeled biomolecules by 1808 coincidence detection of two simultaneously emitted photons from positron–electron annihilation. Although a number of different radiotracers have been successfully employed in PET, only a few, such as 2-[F]fluoro-2-deoxy-d-glucose (FDG) and [F]fluorodopa, have gained widespread application in nuclear medicine. The reason for this is that the regioselective introduction of F into tracer molecules is often non-specific and radiochemical yields (RCY) of the Fl…
Response of an arctic predator guild to collapsing lemming cycles
2012
6 pages; International audience; Alpine and arctic lemming populations appear to be highly sensitive to climate change, and when faced with warmer and shorter winters, their well-known high-amplitude population cycles may collapse. Being keystone species in tundra ecosystems, changed lemming dynamics may convey significant knock-on effects on trophically linked species. Here, we analyse long-term (1988-2010), community-wide monitoring data from two sites in high-arctic Greenland and document how a collapse in collared lemming cyclicity affects the population dynamics of the predator guild. Dramatic changes were observed in two highly specialized lemming predators: snowy owl and stoat. Follo…