Search results for "ddc:000"
showing 9 items of 9 documents
Evidence for the mechanosensor function of filamin in tissue development
2016
AbstractCells integrate mechanical properties of their surroundings to form multicellular, three-dimensional tissues of appropriate size and spatial organisation. Actin cytoskeleton-linked proteins such as talin, vinculin and filamin function as mechanosensors in cells, but it has yet to be tested whether the mechanosensitivity is important for their function in intact tissues. Here we tested, how filamin mechanosensing contributes to oogenesis in Drosophila. Mutations that require more or less force to open the mechanosensor region demonstrate that filamin mechanosensitivity is important for the maturation of actin-rich ring canals that are essential for Drosophila egg development. The ope…
Towards an Internationalization of the Information Systems Curriculum
2012
Globalization has changed the requirements to professionals and students in all branches and sectors significantly in the past decade. However in the domain of Information Systems, these changes have not yet found their way into current study programs and curricula. We identify and validate core internationalization competences and their relation to IS specific competences based on an initial set of competence categories. This is the basis for designing learning services of the future. The presented study aims at validating both and identifying additional categories and competences. In this paper, we present the first results of this study focusing on the internationalization and knowledge …
Restrictions on data-driven political micro-targeting in Germany
2017
The revitalisation of canvassing in recent elections is strongly related to campaigns´ growing possibilities for analysing voter data to gain knowledge about their constituents, identifying their most likely voters and serving up personalised messages through individual conversations. The research literature about political micro-targeting hardly ever focusses on campaigns in parliamentary democracies with strict data protection laws. Based on in-depth expert interviews we introduce a framework of constraints in strategic political communication and reveal several restrictions on the macro, meso and micro levels which hinder the implementation of sophisticated data strategies in Germany. We…
Kulturwissenschaften als Plattform für eine Neukonzeption der Geisteswissenschaften
2014
In der zweiten Halfte des 20. Jahrhunderts wurde die Auseinandersetzung mit – kaum losbaren – Legitimationsproblemen zu einem Charakteristikum der Geisteswissenschaften. Der Versuch der Selbstlegitimierung stellte das humanistische Selbstverstandnis von Geisteswissenschaftlern und Geisteswissenschaftlerinnen auf die Probe und forderte ein wissenschaftsgeschichtliches Interesse, das sich allerdings oftmals in einer Reflexion der naturwissenschaftlichen Arbeit erschopfte. Die geisteswissenschaftliche Arbeit wurde der naturwissenschaftlichen Arbeit als andersartig entgegengesetzt; selten widmeten sich Geisteswissenschaftler jedoch einer detaillierten Analyse von geistes- oder sozialwissenschaf…
April 27–30, 2005 in Addis Ababa: Stemming the Tide: Efforts at Preserving Languages
2012
Conference Review
Removing krypton from xenon by cryogenic distillation to the ppq level
2017
The XENON1T experiment aims for the direct detection of dark matter in a detector filled with 3.3 tons of liquid xenon. In order to achieve the desired sensitivity, the background induced by radioactive decays inside the detector has to be sufficiently low. One major contributor is the β-emitter 85Kr which is present in the xenon. For XENON1T a concentration of natural krypton in xenon natKr/Xe<200ppq (parts per quadrillion, 1ppq=10-15mol/mol) is required. In this work, the design, construction and test of a novel cryogenic distillation column using the common McCabe–Thiele approach is described. The system demonstrated a krypton reduction factor of 6.4 · 10 5 with thermodynamic stability a…
The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography
2016
Scientific reports 6, 35279 (2016). doi:10.1038/srep35279
Realizing total reciprocity violation in the phase for photon scattering
2017
Scientific reports 7, 43114 (2017). doi:10.1038/srep43114
December 13–14, 2007 in Mainz: Workshop on “Language contact in Ethiopia: Examples from Cushitic, Omotic and Semitic languages”
2012
Conference Review