Search results for "ddc:5"
showing 10 items of 1717 documents
Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?
2020
Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …
Deep sequencing of the human retinae reveals the expression of odorant receptors
2017
Several studies have demonstrated that the expression of odorant receptors (ORs) occurs in various tissues. These findings have served as a basis for functional studies that demonstrate the potential of ORs as drug targets for a clinical application. To the best of our knowledge, this report describes the first evaluation of the mRNA expression of ORs and the localization of OR proteins in the human retina that set a stage for subsequent functional analyses. RNA-Sequencing datasets of three individual neural retinae were generated using Next-generation sequencing and were compared to previously published but reanalyzed datasets of the peripheral and the macular human retina and to reference…
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants show…
Deep-learning based reconstruction of the shower maximum X max using the water-Cherenkov detectors of the Pierre Auger Observatory
2021
The atmospheric depth of the air shower maximum $X_{\mathrm{max}}$ is an observable commonly used for the determination of the nuclear mass composition of ultra-high energy cosmic rays. Direct measurements of $X_{\mathrm{max}}$ are performed using observations of the longitudinal shower development with fluorescence telescopes. At the same time, several methods have been proposed for an indirect estimation of $X_{\mathrm{max}}$ from the characteristics of the shower particles registered with surface detector arrays. In this paper, we present a deep neural network (DNN) for the estimation of $X_{\mathrm{max}}$. The reconstruction relies on the signals induced by shower particles in the groun…
Pd2Au36(SR)(24) cluster: structure studies
2015
The location of the Pd atoms in Pd2Au36(SC2H4Ph)(24), is studied both experimentally and theoretically. X-ray photoelectron spectroscopy (XPS) indicates oxidized Pd atoms. Palladium K-edge extended X-ray absorption fine-structure (EXAFS) data clearly show Pd-S bonds, which is supported by far infrared spectroscopy and by comparing theoretical EXAFS spectra in R space and circular dichroism spectra of the staple, surface and core doped structures with experimental spectra.
A concept for the extraction of the most refractory elements at CERN-ISOLDE as carbonyl complex ions
2021
The European physical journal / A 58(5), 94 (2022). doi:10.1140/epja/s10050-022-00739-1
Ultrafast Coherent THz Lattice Dynamics Coupled to Spins in the van der Waals Antiferromagnet FePS3
2022
Coherent THz optical lattice and hybridized phonon–magnon modes are triggered by femtosecond laser pulses in the antiferromagnetic van der Waals semiconductor FePS3. The laser-driven lattice and spin dynamics are investigated in a bulk crystal as well as in a 380 nm-thick exfoliated flake as a function of the excitation photon energy, sample temperature and applied magnetic field. The pump-probe magneto-optical measurements reveal that the amplitude of a coherent phonon mode oscillating at 3.2 THz decreases as the sample is heated up to the Néel temperature. This signal eventually vanishes as the phase transition to the paramagnetic phase occurs, thus revealing its connection to the long-ra…
In situ measurements of background aerosol and subvisible cirrus in the tropical tropopause region
2002
[1] In situ aerosol measurements were performed in the Indian Ocean Intertropical Convergence Zone (ITCZ) region during the Airborne Polar Experiment-Third European Stratospheric Experiment on Ozone (APE-THESEO) field campaign based in Mahe, Seychelles between 24 February and 6 March 1999. These are measurements of particle size distributions with a laser optical particle counter of the Forward Scattering Spectrometer Probe (FSSP)-300 type operated on the Russian M-55 high-altitude research aircraft Geophysica in the tropical upper troposphere and lower stratosphere up to altitudes of 21 km. On 24 and 27 February 1999, ultrathin layers of cirrus clouds were penetrated by Geophysica directly…
Sisubiotus hakaiensis sp. nov. (Tardigrada, Macrobiotidae), a new tardigrade species from Calvert Island (British Columbia, Canada)
2022
Tardigrades reports from British Columbia (Canada) trace back to 1908 and numerous species have been recorded from this region, despite the relatively few published sampling studies. We describe by integrative taxonomy (light microscopy morphology, morphometrics, and DNA sequencing) a new tardigrade species, Sisubiotus hakaiensis sp. nov. from the British Columbia central coast. The new species has been found in moss collected from a vertical rock outcrop near the Hakai Institute Calvert Island Field Station. Sisubiotus hakaiensis sp. nov. differs from all the other known species in the genus by the presence of a labyrinthine layer inside the egg process walls, whereas no consistent differe…
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
2013
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…