Search results for "deaths"

Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results.

2013

A sequential approach including bortezomib induction, intermediate-dose melphalan, and autologous stem cell transplantation (ASCT), followed by lenalidomide consolidation-maintenance, has been evaluated. Efficacy and safety data have been analyzed on intention-to-treat and results updated. Newly diagnosed myeloma patients 65 to 75 years of age (n = 102) received 4 cycles of bortezomib-pegylated liposomal doxorubicin-dexamethasone, tandem melphalan (100 mg/m(2)) followed by ASCT (MEL100-ASCT), 4 cycles of lenalidomide-prednisone consolidation (LP), and lenalidomide maintenance (L) until disease progression. The complete response (CR) rate was 33% after MEL100-ASCT, 48% after LP and 53% after…

Global, regional, and national levels and causes of maternal mortality during 1990-2013: A systematic analysis for the Global Burden of Disease Study…

2014

BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.METHODS: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basi…

Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17

2020

Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage o…

The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study

2022

Abstract Background Injury remains a major concern to public health in the European region. Previous iterations of the Global Burden of Disease (GBD) study showed wide variation in injury death and disability adjusted life year (DALY) rates across Europe, indicating injury inequality gaps between sub-regions and countries. The objectives of this study were to: 1) compare GBD 2019 estimates on injury mortality and DALYs across European sub-regions and countries by cause-of-injury category and sex; 2) examine changes in injury DALY rates over a 20 year-period by cause-of-injury category, sub-region and country; and 3) assess inequalities in injury mortality and DALY rates across the countries…

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

2019

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained ra…

A Forensic Diagnostic Algorithm for Drug-Related Deaths: A Case Series

2022

The best evidence provided in the literature worldwide suggests the importance of harmonizing the investigation in drug-related fatalities. In this study, the application of a multidisciplinary approach in eight cases of drug-related deaths is presented. Although death scene findings could be highly suggestive of drug intoxication, external examination and toxicological screening test alone are insufficient. There are several variables, and it is not always easy to give the proper interpretation of the drug detection. A complete autopsy is necessary to correctly complete organ and tissues sampling for further histological and toxicological studies and obtain body fluids. The use of peripher…

Can immunohistochemical stains aid to rule out pitfalls in suffocation deaths ?

2008

L’autoesposizione a pericolo fra colpa in ambiti illeciti e autoresponsabilità: il caso delle morti da assunzione di stupefacenti

2020

La rilevanza dell'autoresponsabilità della vittima viene considerato in relazione al caso della morte del consumatore di droghe. Si tratta di un una problematica ampiamente esaminata nella giurisprudenza tedesca e in quella italiana, con differenti esiti sulle norme applicabili nei due sitemi penali e ulteriori conseguenze dogmatiche sulla teoria generale della responsabilità penale colposa. The relevance of the victim's self-responsibility is considered in relation to the case of the death of the drug user. This issue has been extensively examined in German and Italian jurisprudence, with different outcomes on the applicable rules in the two criminal systems and further dogmatic consequenc…

Memorializing mass deaths at the border: two cases from Canberra (Australia) and Lampedusa (Italy)

2017

In this paper, we compare two seemingly very similar instances in which individuals and organizations within the borders of the global North have memorialized the deaths of irregular migrants at sea: the SIEV X memorial in Australia’s national capital Canberra, and the Giardino della memoria (Garden of Remembrance) on the Italian island of Lampedusa. Unlike ephemeral manifestations of grief, potentially these memorials have effects that reach well beyond their creation. We relate the differences between the memorials to the contexts within which they were created: an immediate local response involving people directly affected by the disaster’s aftermath, on the one hand, and a delayed natio…