Search results for "delay"
showing 10 items of 814 documents
Preclinical models for colonic absorption, application to controlled release formulation development.
2018
Oral controlled release (CR) formulations have many benefits and have become a valuable resource for the local and systemic administration of drugs. The most important characteristic of these pharmaceutical products is that drug absorption occurs mainly in the colon. Therefore, this review analyses the physiological and physicochemical features that may affect an orally administered CR product, as well as the different strategies to develop a CR dosage form and the methods used to evaluate the formulation efficacy. The models available to study the intestinal permeability and their applicability to colonic permeability determinations are also discussed.
Relationship between time from symptom's onset to diagnosis and prognosis in patients with symptomatic colorectal cancer
2022
Multicenter study [Abstract] Background: Controversy exists regarding the relationship of the outcome of patients with colorectal cancer (CRC) with the time from symptom onset to diagnosis. The aim of this study is to investigate this association, with the assumption that this relationship was nonlinear and with adjustment for multiple confounders, such as tumor grade, symptoms, or admission to an emergency department. Methods: This multicenter study with prospective follow-up was performed in five regions of Spain from 2010 to 2012. Symptomatic cases of incident CRC from a previous study were examined. At the time of diagnosis, each patient was interviewed, and the associated hospital and …
BARGAINING WITH COMMITMENT UNDER AN UNCERTAIN DEADLINE
2006
We consider an infinite horizon bargaining game in which a deadline can arise with positive probability and where players possess an endogenous commitment device. We show that for any truncation of the game, the equilibrium agreement can only take place if the deadline arises within this finite horizon. Since the deadline is an uncertain event, the equilibrium exhibits agreements which are delayed with positive probability.
Effects of self-myofascial release: A systematic review.
2015
Summary Background Self-myofascial release (SMFR) is a type of myofascial release performed by the individual themselves rather than by a clinician, typically using a tool. Objectives To review the literature regarding studies exploring acute and chronic clinical effects of SMFR. Methods PubMed and Google Scholar databases were searched during February 2015 for studies containing words related to the topic of SMFR. Results Acutely, SMFR seems to increase flexibility and reduce muscle soreness but does not impede athletic performance. It may lead to improved arterial function, improved vascular endothelial function, and increased parasympathetic nervous system activity acutely, which could b…
A Computational Technique for Solving Singularly Perturbed Delay Partial Differential Equations
2021
Abstract In this work, a matrix method based on Laguerre series to solve singularly perturbed second order delay parabolic convection-diffusion and reaction-diffusion type problems involving boundary and initial conditions is introduced. The approximate solution of the problem is obtained by truncated Laguerre series. Moreover convergence analysis is introduced and stability is explained. Besides, a test case is given and the error analysis is considered by the different norms in order to show the applicability of the method.
A Random Trajectory Approach for the Development of Nonstationary Channel Models Capturing Different Scales of Fading
2017
This paper introduces a new approach to developing stochastic nonstationary channel models, the randomness of which originates from a random trajectory of the mobile station (MS) rather than from the scattering area. The new approach is employed by utilizing a random trajectory model based on the primitives of Brownian fields (BFs), whereas the position of scatterers can be generated from an arbitrarily 2-D distribution function. The employed trajectory model generates random paths along which the MS travels from a given starting point to a fixed predefined destination point. To capture the path loss, the gain of each multipath component is modeled by a negative power law applied to the tra…
Doppler Shift Characterization of Wideband Mobile Radio Channels
2019
The prevailing approach for characterizing the Doppler shift (DS) of mobile radio channels assumes the transmission of an unmodulated carrier. This consideration is valid for the analysis of narrowband channels, but its pertinence is questionable in regards to the modeling of wideband channels. In this correspondence, we redefine the DS from a time-frequency analysis perspective that does not depend on the aforementioned assumption. We systematically demonstrate that the DS can be characterized by the instantaneous frequency of the channel transfer function. This generic definition makes evident a fundamental aspect of the DS that is seldom acknowledged, namely, the DS is a frequency-varyin…
Interchannel Interference and Mitigation in Distributed MIMO RF Sensing
2021
In this paper, we analyze and mitigate the cross-channel interference, which is found in multiple-input multiple-output (MIMO) radio frequency (RF) sensing systems. For a millimeter wave (mm-Wave) MIMO system, we present a geometrical three-dimensional (3D) channel model to simulate the time-variant (TV) trajectories of a moving scatterer. We collected RF data using a state-of-the-art radar known as Ancortek SDR-KIT 2400T2R4, which is a frequency-modulated continuous wave (FMCW) MIMO radar system operating in the K-band. The Ancortek radar is currently the only K-band MIMO commercial radar system that offers customized antenna configurations. It is shown that this radar system encounters th…
Doppler Power Characteristics Obtained from Calibrated Channel State Information for Human Activity Recognition
2020
This paper demonstrates the time-variant (TV) Doppler power characteristics of human activities using measured channel state information (CSI). We model the measured CSI as a complex channel transfer function corresponding to a 3D non-stationary multipath fading channel consisting of a fixed transmitter, a fixed receiver, fixed scatterers representing fixed objects, and a cluster of moving scatterers representing a moving person performing some human activities. We demonstrate the relationship between the TV Doppler frequency caused by each moving scatterer and the rate of change of its corresponding TV propagation delay. Furthermore, we express the TV mean Doppler shift in terms of the pat…
Modelling and Analysis of Non-Stationary Multipath Fading Channels with Time-Variant Angles of Arrival
2017
In mobile radio channel modelling, it is generally assumed that the angles of arrival (AOAs) are independent of time. This assumption does in general not agree with real-world channels in which the AOAs vary with the position of a moving receiver. In this paper, we first present a mathematical model for the time-variant AOAs. This model serves as the basis for the development of two non-stationary multipath fading channels models. The statistical properties of both channel models are analysed with emphasis on the time-dependent autocorrelation function (ACF), time-dependent mean Doppler shift, time-dependent Doppler spread, and the Wigner-Ville spectrum. It is shown that these characteristi…