Search results for "derived"
showing 10 items of 452 documents
Tangential behavior of functions and conical densities of Hausdorff measures.
2005
We construct a $C^1$-function $f\colon [0,1]\to \mathbb{R}$ such that for almost all $x\in(0,1)$, there is $r>0$ for which $f(y)>f(x)+f'(x)(y-x)$ when $y\in(x,x+r)$ and $f(y)< f(x)+f'(x)(y-x)$ when $y\in(x-r,x)$. The existence of such functions is related to a problem concerning conical density properties of Hausdorff measures on $\mathbb{R}^n$. We also discuss the tangential behavior of typical $C^1$-functions, using an improvement of Jarnik's theorem on essential derived numbers
Homological Projective Duality for Determinantal Varieties
2016
In this paper we prove Homological Projective Duality for crepant categorical resolutions of several classes of linear determinantal varieties. By this we mean varieties that are cut out by the minors of a given rank of a n x m matrix of linear forms on a given projective space. As applications, we obtain pairs of derived-equivalent Calabi-Yau manifolds, and address a question by A. Bondal asking whether the derived category of any smooth projective variety can be fully faithfully embedded in the derived category of a smooth Fano variety. Moreover we discuss the relation between rationality and categorical representability in codimension two for determinantal varieties.
Rings with algebraic n-engel elements
1994
(1994). Rings with algebraic n-engel elements. Communications in Algebra: Vol. 22, No. 5, pp. 1685-1701.
Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Primin…
2022
Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these cells are expanded in two-dimensional (2D) cultures, and, in that case, MSCs undergo genotypic/phenotypic changes resulting in a loss of their therapeutic capabilities. Moreover, several clinical trials using MSCs have shown controversial results with moderate/insufficient therapeutic responses. Different priming methods were tested to improve MSC effects, and three-dimensional (3D) culturing techniques were also examined. MSC spheroids display increased therapeutic properties, and, in this context, it is crucial…
Human Amnion-Derived Mesenchymal Stromal Cells: A New Potential Treatment for Carbapenem-Resistant Enterobacterales in Decompensated Cirrhosis
2022
Background: Spontaneous bacterial peritonitis (SBP) is a severe and often fatal infection in patients with decompensated cirrhosis and ascites. The only cure for SBP is antibiotic therapy, but the emerging problem of bacterial resistance requires novel therapeutic strategies. Human amniotic mesenchymal stromal cells (hA-MSCs) possess immunomodulatory and anti-inflammatory properties that can be harnessed as a therapy in such a context. Methods: An in vitro applications of hA-MSCs in ascitic fluid (AF) of cirrhotic patients, subsequently infected with carbapenem-resistant Enterobacterales, was performed. We evaluated the effects of hA-MSCs on bacterial load, innate immunity factors, and macr…
Extracellular Vesicles from Plants: Current Knowledge and Open Questions.
2021
The scientific interest in the beneficial properties of natural substances has been recognized for decades, as well as the growing attention in extracellular vesicles (EVs) released by different organisms, in particular from animal cells. However, there is increasing interest in the isolation and biological and functional characterization of these lipoproteic structures in the plant kingdom. Similar to animal vesicles, these plant-derived extracellular vesicles (PDEVs) exhibit a complex content of small RNAs, proteins, lipids, and other metabolites. This sophisticated composition enables PDEVs to be therapeutically attractive. In this review, we report and discuss current knowledge on PDEVs…
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
2021
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway is activated under the interaction of a broad number of profibrotic/pro-inflammatory cytokines, such as IL-6, IL-11, and IL-13, among others, which are increased in different ILDs. Similarly, several growth factors over-expressed in ILDs, such as platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1), and fibroblast growth factor (FGF) activate JAK/STAT by canonical or non-canonical pathways, which indicates a predominant role of JAK/STAT in ILDs. Between the different JAK/STAT iso…
Novel Narrow-Band Spectral Interference Filter with Very High Transmittance
2011
We report a novel scheme to improve the effective transmission of a standard interference filter, and demonstrate over 97% passband transmission. Such high efficiency is critical for quantum information applications, e.g. high-efficiency single-photon generation utilizing parametric down-conversion. The scheme can also be modified to function with a tilted filter, thereby allowing tuning of the passband frequency. In addition, the tilted configuration creates an infinite number of consecutive reflections from and transmissions through the filter, further improving the net filter transmission. Because spectral interference filters are a key element in optical quantum information experiments …
PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling
2006
Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRalpha in the adult SVZ. Specifically labeled PDGFRalpha expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRalpha in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias wi…
Efficacy and safety of rituximab with and without methotrexate in the treatment of rheumatoid arthritis patients: Results from the GISEA register
2014
Abstract Introduction Rituximab (RTX) is a monoclonal anti-CD20 antibody approved for the treatment of rheumatoid arthritis (RA) in association with methotrexate (MTX). Objectives To evaluate the efficacy and safety of RTX–MTX combination therapy compared with RTX alone in the treatment of RA. Methods We analyzed data from a prospective cohort study, the Italian biologic register GISEA, to investigate the efficacy and safety of rituximab. Moreover, the adverse events (AE) and the causes of discontinuation therapy were analyzed. Results We identified 338 RA patients, 162 treated with RTX and 176 with RTX–MTX. After 52 and 104 weeks of therapy the disease activity score in 28 joints and the H…